Ilongeza njani i-HPMC ukukhutshwa kwechiza?

IHydroxypropyl methylcellulose (HPMC) yipolymer yokwenziwa esetyenziswa kakhulu kwishishini lamachiza ukulawula ukukhutshwa kwamachiza. I-non-ionic, i-polymer e-soluble yamanzi eyenza i-gel phambi kwamanzi. I-HPMC isetyenziselwa ukuguqula izinga lokukhululwa kwamachiza kwiifom zedosi, ezifana neepilisi, iipilisi, kunye nokunqunyanyiswa. Ikwasetyenziswa njenge-binder, disintegrant, kunye ne-lubricant xa kusenziwa iipilisi kunye ne-capsules.

I-HPMC isebenza ngokwenza ijeli yematrix ejikeleze amasuntswana echiza. Le matrix yejeli i-semi-permeable, oku kuthetha ukuba ivumela amanzi ukuba adlule kuyo, kodwa hayi amasuntswana eziyobisi. Njengoko amanzi edlula kwi-matrix yejeli, anyibilika kancinane amasuntswana echiza, ewakhulula kwindawo engqongileyo. Le nkqubo yaziwa ngokuba yi-diffusion-controlled release.

Ireyithi yokukhululwa okulawulwa yi-diffusion inokulawulwa ngokulungelelanisa iimpawu ze-HPMC gel matrix. Umzekelo, i-viscosity ye-gel matrix inokunyuswa ngokongeza i-HPMC eninzi, eya kuthi icothise isantya sokukhululwa okulawulwayo. Ubungakanani bamasuntswana echiza nawo bunokulungelelaniswa, njengoko amasuntswana amancinci aya kusasazeka ngokukhawuleza kunamasuntswana amakhulu.

Ukongeza ekulawuleni izinga lokukhululwa kwamachiza, i-HPMC nayo inezinye iipropathi eziluncedo. Ayinabuthi, ayicaphukisi, kwaye ayinayo i-allergenic, iyenza ikhuseleke ukuba isetyenziswe kwimiqulu yamayeza. Kwakhona i-non-hygroscopic, oku kuthetha ukuba ayifaki umswakama ovela kwindalo, okunceda ukugcina ukuzinza kokuqulunqwa.

I-HPMC sisixhobo esisebenzayo sokulawula izinga lokukhululwa kwamachiza. Ngokulungelelanisa iipropathi ze-HPMC gel matrix, isantya sokukhululwa okulawulwa yi-diffusion sinokulungelelaniswa ukuhlangabezana neprofayili efunekayo yokukhululwa. Oku kuvumela uphuhliso lwemixube ekhupha amachiza ngesantya esilawulwayo kwixesha elide.