HEMC Hydroxyethyl Methyl Cellulose

IHydroxyethyl methyl cellulose (HEMC) yipolymer enyibilikayo emanzini eqhele ukusetyenziswa kumashishini ahlukeneyo, kubandakanya amayeza, ukutya, kunye namashishini okwakha. I-HEMC ivela kwi-cellulose kwaye iguqulwa ngokongezwa kwamaqela amabini e-methyl kunye ne-hydroxyethyl, enika iipropati ezikhethekileyo kunye neenzuzo.

Kwishishini lamachiza, i-HEMC isetyenziswa ngokuqhelekileyo njenge-excipient kwi-tablet formulations, i-topical formulations, kunye namalungiselelo ophthalmic. I-HEMC yaziwa ngokugqwesa kwayo ukwenza ifilimu kunye neempawu ezityebisayo, ezenza kube lolona khetho lufanelekileyo kwezi zicelo.

Enye yeenzuzo eziphambili zokusebenzisa i-HEMC ekuqulunqweni kwamachiza kukukwazi ukuphucula i-viscosity kunye nokuzinza kokuqulunqwa. I-HEMC inobunzima obuphezulu bemolekyuli kunye neqondo eliphezulu lokutshintshela, elinika iipropati ezibalaseleyo zokujiya. Isenokwenza ifilimu ezinzileyo kunye nexesha elide phezu kwesikhumba okanye iliso, elinceda ukugcina isithako seyeza esisebenzayo (API) sidibanisa nommandla ojoliswe kuyo ixesha elide. Ukongezelela, ifilimu inokubonelela ngomqobo okhuselayo, onokunceda ukunciphisa ukucaphuka kunye nokuphucula intuthuzelo yesigulane.

Olunye uncedo lwe-HEMC kukukwazi ukuphucula ukunyibilika kunye ne-bioavailability yee-APIs ezinganyibiliki kakuhle. I-HEMC inokwenza i-gel-like layer kwi-tablet okanye i-topical formulation, enokukunceda ukwandisa indawo ekhoyo yokutshatyalaliswa kunye nokuphucula izinga kunye nobukhulu bokukhutshwa kweziyobisi. Oku kunokukhokelela ekusebenzeni okuphuculweyo kunye neziphumo zonyango.

I-HEMC yaziwa nangokuhambelana kwayo kunye nokhuseleko. Yinto engeyiyo ityhefu kunye neyokungathukutheli esetyenziswe ngokubanzi kwimixube yamachiza iminyaka emininzi. Oku kwenza kube lukhetho olufanelekileyo kwizicelo ezininzi zamachiza, kubandakanywa nezo ziya kusetyenziswa luluhlu olubanzi lwezigulane, kubandakanywa nezo zinolusu olubuthathaka okanye ezinye iimeko zempilo eziphantsi.

Kwishishini lokutya, i-HEMC isetyenziswa ngokuqhelekileyo njenge-ejenti yokuqina kunye nokuzinzisa kwiimveliso zokutya ezahlukeneyo. Isetyenziselwa ukunxitywa kwesaladi, iisosi, i-ayisikrimu, kunye nokunye ukutya ukuphucula ukuthungwa, i-viscosity, kunye nokuzinza. I-HEMC ikwasetyenziswa kushishino lokwakha njengento etyebisayo kunye nesibophelelo kwiimveliso ezisekwe kwisamente, ezifana nokunamathelisa iithayile, iigrouts, kunye nodaka.

Isishwankathelo, i-HEMC yipolymer enyibilikayo esetyenziswa kakhulu emanzini enezicelo ezininzi kumayeza, ukutya, kunye namashishini okwakha. Iipropati zayo zokwenza ifilimu kunye nokuqina, ukukwazi ukuphucula ukunyibilika kunye ne-bioavailability, kunye ne-biocompatibility yenza kube lukhetho olufanelekileyo kwizicelo ezininzi. Nangona kunjalo, abaqulunqi kufuneka bayiqonde imida yayo kwaye baqinisekise ukuba ifanelekile kwisicelo esithile ngaphambi kokuba ibandakanywe kuqulunqo.