Umahluko phakathi kwe-CMC kunye ne-HPMC

I-Carboxymethyl cellulose (CMC) kunye ne-hydroxypropyl methylcellulose (HPMC) zimbini iindidi ze-cellulose derivatives ezisetyenziswa ngokubanzi kumashishini okutya, amayeza, kunye nokunyamekela komntu. Ngelixa zombini zisetyenziswa njengezinto ezityebileyo, izinzisi, kunye nezimiliseli, kukho umahluko obalulekileyo phakathi kwe-CMC kunye ne-HPMC ezenza zilungele usetyenziso olwahlukileyo. Kweli nqaku, siza kuxoxa umahluko phakathi CMC kunye HPMC ngokwemiqathango ubume imichiza yabo, iipropati, ukusetyenziswa, kunye nokhuseleko.

1. Ulwakhiwo lweMichiza

I-CMC yipolymer enyibilikayo emanzini ephuma kwi-cellulose, eyipolymer yendalo efumaneka kwiindonga zeeseli zesityalo. Ubume bekhemikhali be-CMC bubonakaliswe ngamaqela e-carboxymethyl (-CH2-COOH) afakwe kwi-backbone ye-cellulose. Iqondo lokutshintshela (DS) le-CMC libhekisa kwinani lamaqela e-carboxymethyl akhoyo ngokweyunithi ye-anhydroglucose (AGU) yomqolo we-cellulose. I-DS ye-CMC inokuqala ukusuka kwi-0.2 ukuya kwi-1.5, kunye namaxabiso aphezulu e-DS abonisa iqondo eliphezulu lokutshintshwa.

I-HPMC ikwayipolymer enyibilikayo emanzini ephuma kwiselulosi. Nangona kunjalo, ngokungafaniyo ne-CMC, i-HPMC iguqulwe nge-hydroxypropyl kunye namaqela e-methyl. Amaqela e-hydroxypropyl (-OCH2CHOHCH3) afakwe kumaqela e-hydroxyl kwi-cellulose backbone, ngelixa amaqela e-methyl (-CH3) afakwe kumaqela e-hydroxypropyl. Iqondo lokutshintshwa kwe-HPMC libhekiselele kwinani le-hydroxypropyl kunye namaqela e-methyl akhoyo nge-AGU yomqolo we-cellulose. I-DS ye-HPMC inokuqala ukusuka kwi-0.1 ukuya kwi-3.0, kunye namaxabiso aphezulu e-DS abonisa iqondo eliphezulu lokutshintshwa.

2. Iipropati

I-CMC kunye ne-HPMC zineempawu ezahlukeneyo ezenza ukuba zilungele izicelo ezahlukeneyo. Ezinye zeempawu eziphambili ze-CMC kunye ne-HPMC zidweliswe ngezantsi:

a. Ukunyibilika: I-CMC inyibilika kakhulu emanzini kwaye yenza izisombululo ezicacileyo, nezibonakalayo. I-HPMC nayo iyanyibilika kakhulu emanzini, kodwa izisombululo zinokuba ne-turbid ngokuxhomekeke kwiqondo lokuthatha indawo.

b. I-Rheology: I-CMC yimathiriyeli ye-pseudoplastic, ethetha ukuba ibonisa ukuziphatha kokucheba. Oku kuthetha ukuba i-viscosity ye-CMC iyancipha njengoko izinga lokucheba linyuka. I-HPMC, kwelinye icala, i-Newtonian material, ethetha ukuba i-viscosity yayo ihlala ihleli kungakhathaliseki ukuba isantya sokucheba.

c. Iimpawu zokwenza ifilimu: I-CMC ineempawu ezilungileyo zokwenza ifilimu, ezenza ukuba zilungele ukusetyenziswa kwiingubo kunye neefilimu. I-HPMC ikwanazo neepropati zokwenza ifilimu, kodwa iifilimu zinokuba brittle kwaye zithande ukuqhekeka.

d. Uzinzo: I-CMC izinzile kuluhlu olubanzi lwe-pH kunye neemeko zobushushu. I-HPMC nayo izinzile kuluhlu olubanzi lwe-pH, kodwa ukuzinza kwayo kunokuchatshazelwa ngamaqondo obushushu aphezulu.

3. Usebenzisa

I-CMC kunye ne-HPMC zisetyenziswa kuluhlu olubanzi lwezicelo kumashishini okutya, amayeza, kunye nokhathalelo lomntu. Ezinye zezinto eziphambili zokusetyenziswa kwe-CMC kunye ne-HPMC zidweliswe ngezantsi:

a. Ishishini lokutya: I-CMC iqhele ukusetyenziswa njenge-thickener, i-stabilizer, kunye ne-emulsifier kwiimveliso zokutya ezifana ne-ayisikrimu, izinxibo zesaladi, kunye neempahla ezibhakiweyo. I-HPMC ikwasetyenziswa njenge-thickener kunye nokuzinzisa kwiimveliso zokutya, kodwa isetyenziswa kakhulu njenge-agent yokugquma kwiimveliso zeconfectionery ezifana ne-gummy candies kunye neetshokolethi.

b. Umzi-mveliso wamachiza: I-CMC isetyenziswa njenge-binder, i-disintegrant, kunye ne-ejenti yokugquma i-tablet ekuxutyweni kwamayeza. I-HPMC ikwasetyenziswa njenge-binder, i-disintegrant, kunye ne-ejenti yokwambathisa ithebhulethi kuqulunqo lwamayeza.