I-Hydroxyethyl Cellulose (HEC) kunye nezinye i-cellulose ethers (ezifana ne-hydroxypropyl methylcellulose (HPMC), i-methylcellulose (MC), i-hydroxypropyl cellulose (HPC) kunye ne-carboxymethyl cellulose (CMC)) zi-polymers ezininzi ezisetyenziswa ngokubanzi kwishishini, ukwakhiwa, amayeza, ukutya kunye nemihla ngemihla. amashishini amachiza. Ezi zinto ziphuma kwi-cellulose zenziwe nge-cellulose yokuguqula iikhemikhali kwaye zibe ne-solubility yamanzi, ukuqina, ukuzinza kunye neempawu zefilimu.
1. I-Hydroxyethyl Cellulose (HEC)
1.1 Ulwakhiwo lweMichiza kunye neePropati
I-Hydroxyethyl Cellulose (HEC) yenziwe nge-hydroxyethylation ye-cellulose kunye ne-ethylene oxide phantsi kweemeko ze-alkaline. Isakhiwo esisisiseko se-HEC yi-ether bond eyenziwe ngokutshintshwa kweqela le-hydroxyl kwi-molecule ye-cellulose ngeqela le-hydroxyethyl. Olu lwakhiwo lunika i-HEC iipropati ezizodwa:
Ukunyibilika kwamanzi: I-HEC iyanyibilika kumanzi abandayo kunye nashushu ukwenza isisombululo se-colloidal esicacileyo.
Ukuqina: I-HEC ineempawu ezigqwesileyo zokujiya kwaye isetyenziswa ngokubanzi kwizicelo ezifuna ulawulo lwe-viscosity.
Ukuzinza: Isisombululo se-HEC sinokuzinza okuphezulu kwiindidi ezahlukeneyo ze-pH.
I-Biocompatibility: I-HEC ayinayo ityhefu, ayicaphukisi, kwaye inobuhlobo kumzimba womntu kunye nokusingqongileyo.
1.2 Iinkalo zesicelo
Izinto zokwakha: zisetyenziswa njenge-thickener kunye ne-arhente yokugcina amanzi kudaka lwesamente kunye neemveliso zegypsum.
Iingubo kunye neepeyinti: zisetyenziswa njenge-thickener, i-agent exhomayo kunye ne-stabilizer.
Iikhemikhali zemihla ngemihla: zisetyenziswa njenge-thickener kwiimfuno zemihla ngemihla ezifana nezicoci kunye neshampu.
Intsimi yamachiza: isetyenziswa njengento yokuncamathelisa, i-thickener kunye ne-arhente yokuxhoma kwiipilisi zamachiza.
1.3 Izinto eziluncedo nezingeloncedo
Izinto eziluncedo: ukunyibilika kakuhle kwamanzi, ukuzinza kweekhemikhali, ukuguquguquka kwe-pH ebanzi kunye nokungabi yingozi.
Izinto ezingeloncedo: ukunyibilika okulambathayo kwezinye izinyibilikisi, kwaye ixabiso linokuba phezulu kancinci kunezinye ii-ether zeselulosi.
2. Ukuthelekiswa kwezinye ii-ether ze-cellulose
2.1 IHydroxypropyl methylcellulose (HPMC)
2.1.1 Ubume beekhemikhali kunye neempawu
I-HPMC yenziwe nge-cellulose ngokusebenzisa i-methylation kunye ne-hydroxypropylation reactions. Isakhiwo sayo siqulethe zombini i-methoxy (-OCH3) kunye ne-hydroxypropoxy (-OCH2CH (OH) CH3) substitutions.
Ukunyibilika kwamanzi: I-HPMC inyibilika emanzini abandayo ukwenza isisombululo se-colloidal esicacileyo; ayinyibiliki kakuhle emanzini ashushu.
Ipropathi etyebisayo: Inobuchule obubalaseleyo bokujiya.
Iimpawu zeGelling: Yenza ijeli xa ishushu kwaye ibuyela kwimeko yayo yangaphambili xa ipholile.
2.1.2 Iindawo zokufaka izicelo
Izinto zokwakha: Isetyenziswa njenge-thickener kunye ne-arhente yokugcina amanzi kwizinto ezisekelwe kwisamente kunye ne-gypsum-based.
Ukutya: Isetyenziswa njenge-emulsifier kunye ne-stabilizer.
Iyeza: Isetyenziswa njenge-excipient kwii-capsules zamachiza kunye neepilisi.
2.1.3 Izinto eziluncedo nezingeloncedo
Izinto eziluncedo: Ukusebenza kakuhle kokuqina kunye neempawu zegelling.
Ukungalungi: Inovelwano kubushushu kwaye inokusilela kwizicelo zobushushu obuphezulu.
2.2 I-Methyl cellulose (MC)
2.2.1 Ubume beekhemikhali kunye neempawu
I-MC ifunyenwe nge-methylation ye-cellulose kwaye iqulethe i-methoxy (-OCH3) substitutions.
Ukunyibilika kwamanzi: inyibilika kakuhle emanzini abandayo ukwenza isisombululo se-colloidal esicacileyo.
Ukutyeba: kunefuthe elibonakalayo lokujiya.
I-Thermal Gelation: yenza ijeli xa ishushu kwaye ihlanjululwe xa ipholile.
2.2.2 Iindawo zokufaka izicelo
Izixhobo zokwakha: Isetyenziswa njengento ejiyayo kunye nokugcina amanzi ukwenza udaka kunye nepeyinti.
Ukutya: kusetyenziswe njenge-emulsifier kunye ne-stabilizer.
2.2.3 Izinto eziluncedo nezingeloncedo
I-Advantages: isakhono esinamandla sokuqina, esihlala sisetyenziswa kwitekhnoloji yokucubungula okubandayo.
Ukungalungi: i-heat-sensitive, ayikwazi ukusetyenziswa kumaqondo aphezulu.
2.3 Iselulosi yeHydroxypropyl (HPC)
2.3.1 Ubume beekhemikhali kunye neempawu
I-HPC ifumaneka nge-hydroxypropyl cellulose. Isakhiwo sayo siqulethe i-hydroxypropoxy (-OCH2CH (OH) CH3).
Ukunyibilika kwamanzi: inyibilika emanzini abandayo kunye nezinyibilikisi eziphilayo.
Ukuqina: ukusebenza kakuhle kokuqina.
Ipropati yokwenza ifilimu: yenza ifilimu eyomeleleyo.
2.3.2 Iinkalo zesicelo
Iyeza: lisetyenziswa njengezinto zokugquma kunye ne-tablet excipient kumachiza.
Ukutya: kusetyenziswa njenge-thickener kunye ne-stabilizer.
2.3.3 Izinto eziluncedo nezingeloncedo
Izinto eziluncedo: ukunyibilika kwezinto ezininzi kunye nepropathi egqwesileyo yokwenza ifilimu.
Ukungalungi: ixabiso eliphezulu.
2.4 Carboxymethyl cellulose (CMC)
2.4.1 Ubume bekhemikhali kunye neempawu
I-CMC yenziwe ngokuphendula i-cellulose nge-chloroacetic acid, kwaye iqulethe iqela le-carboxymethyl (-CH2COOH) kwisakhiwo sayo.
Ukunyibilika kwamanzi: Ukunyibilika emanzini abandayo kunye namanzi ashushu.
Ipropathi etyebisayo: isiphumo esibonakalayo sokujiya.
Ionicity: yeye-anionic cellulose ether.
2.4.2 Iinkalo zesicelo
Ukutya: kusetyenziswa njenge-thickener kunye ne-stabilizer.
Iikhemikhali zemihla ngemihla: zisetyenziswa njenge-thickener kwisicoci.
Ukwenziwa kwephepha: kusetyenziswe njengesongezo sokugquma iphepha.
2.4.3 Izinto eziluncedo nezingeloncedo
Izinto eziluncedo: ukutyeba okulungileyo kunye nemimandla yesicelo ebanzi.
Ukungalungi: ubuthathaka kwi-electrolytes, i-ion kwisisombululo inokuchaphazela ukusebenza.
3. Uthelekiso olubanzi
3.1 Ukuqiniswa kwentsebenzo
I-HEC kunye ne-HPMC zinomsebenzi ofanayo wokuqina kwaye zombini zinesiphumo esihle sokuqina. Nangona kunjalo, i-HEC ine-solubility engcono yamanzi kwaye ifanelekile kwizicelo ezifuna ukungafihli kunye nokucaphuka okuphantsi. I-HPMC iluncedo ngakumbi kwizicelo ezifuna ukufudumeza kwijeli ngenxa yeempawu zayo ze-thermogel.
3.2 Ukunyibilika kwamanzi
I-HEC kunye ne-CMC zinokunyibilika zombini kumanzi abandayo nashushu, ngelixa i-HPMC kunye ne-MC zinyibilika ikakhulu emanzini abandayo. I-HPC ikhethwa xa ukuhambelana kwezinto ezininzi zokunyibilikisa kufuneka.
3.3 Ixabiso kunye noluhlu lwesicelo
I-HEC ihlala inexabiso eliphakathi kwaye isetyenziswa ngokubanzi. Nangona i-HPC inentsebenzo egqwesileyo, idla ngokusetyenziswa kwizicelo ezifunwa kakhulu ngenxa yeendleko zayo eziphezulu. I-CMC inendawo kwizicelo ezininzi eziphantsi ngexabiso eliphantsi kunye nokusebenza kakuhle.
I-Hydroxyethyl cellulose (HEC) ibe yenye yezona zinto zisetyenziswa kakhulu kwi-cellulose ethers ngenxa yokunyibilika kakuhle kwamanzi, ukuzinza kunye nokukwazi ukutyeba. Xa kuthelekiswa nezinye i-cellulose ethers, i-HEC ineenzuzo ezithile kwi-solubility yamanzi kunye nokuzinza kweekhemikhali, kwaye ifanelekile kwizicelo ezifuna izisombululo ezicacileyo kunye nokuguquguquka kwe-pH ebanzi. I-HPMC iyagqwesa kwiindawo ezithile ezithile ngenxa yokuqina kwayo kunye neempawu ze-thermal gelling, ngelixa i-HPC kunye ne-CMC zibambe indawo ebalulekileyo kwiinkalo zabo zesicelo ngenxa yeepropati zabo zokwenza ifilimu kunye neenzuzo zeendleko. Ngokweemfuno ezithile zesicelo, ukukhetha i-ether ye-cellulose efanelekileyo kunokwandisa ukusebenza kwemveliso kunye nokusebenza kakuhle kweendleko.
Ixesha lokuposa: Jul-10-2024