Ukusetyenziswa konyango olulawulwa yi-CMC

I-CMC (i-carboxymethylcellulose) i-polymer e-soluble yamanzi, i-anionic esetyenziswa ngokubanzi njenge-excipient kumashishini amayeza. Ithathwe kwi-cellulose, i-polysaccharide eyenzeka ngokwemvelo, ngokongeza amaqela e-carboxymethyl kwisakhiwo sayo. I-CMC yaziwa ngobuchule bayo bokwenza ifilimu kunye neempawu ezityebisayo, nto leyo eyenza ukuba ibe sisithako esisebenza ngeendlela ezininzi nesiyimfuneko kwimixube emininzi yamayeza.

Kumachiza, i-CMC idla ngokusetyenziswa njenge-thickener, stabilizer, kunye ne-lubricant. Njenge-thickener, i-CMC isetyenziswa kuluhlu olubanzi lokuqulunqwa, njengama-creams, lotions, kunye neegels, ukubonelela nge-viscosity kunye nokuphucula ukuthungwa kwabo. Oku kunceda ukunyusa uzinzo kunye nokuhambelana kwemveliso, okwenza kube lula ukufaka isicelo kwaye kube mnandi ngakumbi ukuba izigulane zisebenzise. I-CMC iphinda isetyenziswe njenge-stabilizer kwi-suspensions kunye ne-emulsions, inceda ukuthintela amasuntswana ekuzinzeni nasekuqinisekiseni ukuba imveliso ihlala ifana. Ukongezelela, i-CMC isetyenziselwa i-lubricant kwi-tablet kunye ne-capsule formulations, inceda ukuphucula ukuhamba kwayo kunye nokulula ukugwinya.

Esinye sezona zicelo zixhaphakileyo zonyango lwe-CMC kukuqulunqa amehlo. I-CMC isetyenziswa kumathontsi eliso kunye neenyembezi ezenziweyo ukubonelela ngokuthambisa kunye nokunciphisa iimpawu zamehlo ezomileyo. Iliso elomileyo yimeko eqhelekileyo eyenzeka xa amehlo enganikeli iinyembezi ngokwaneleyo okanye xa iinyembezi ziphuma umphunga ngokukhawuleza. Oku kunokukhokelela ekucaphukeni, ukubomvu, kunye nokungakhululeki. I-CMC yonyango olusebenzayo kwiliso elomileyo kuba inceda ukuphucula ukuzinza kunye nokugcinwa kwexesha lefilimu yokukrazula kwi-ocular surface, ngaloo ndlela inciphisa ukoma kunye nokucaphuka.

Ukongeza kusetyenziso lwayo kwimixube ye-ophthalmic, i-CMC ikwasetyenziswa kwamanye amayeza omlomo ukuphucula ukunyibilika kwawo kunye nesantya sonyibiliko. I-CMC ingasetyenziswa njenge-disintegrant kwiipilisi, ibanceda ukuba baphule ngokukhawuleza kwi-gastrointestinal tract kunye nokuphucula i-bioavailability yesithako esisebenzayo. I-CMC ingasetyenziswa njenge-binder kwi-tablet kunye ne-capsule formulations, inceda ukubamba izithako ezisebenzayo kunye nokuphucula ukunyanzeliswa kwazo.

I-CMC ingumxhasi owamkelwe ngokubanzi kwishishini loxubo-mayeza kwaye ilawulwa zii-arhente ezahlukeneyo zolawulo lwamachiza kwihlabathi jikelele. EUnited States, i-FDA (uLawulo lokuTya kunye neDrugs) ilawula i-CMC njengento edibanisa ukutya kunye nesithako esingasebenziyo kumachiza. I-FDA iseke iinkcukacha zomgangatho kunye nokucoceka kwe-CMC esetyenziswa kumachiza kwaye ibeke amanqanaba aphezulu okungcola kunye nezinyibilikisi ezishiyekileyo.

Kwi-European Union, i-CMC ilawulwa yi-European Pharmacopoeia (Ph. Eur.) kwaye ifakwe kuluhlu lwezinto ezincedisayo ezinokusetyenziswa kwiimveliso zonyango. I-Ph. Eur. iye yaseka iinkcukacha zomgangatho kunye nokucoceka kwe-CMC esetyenziswa kumachiza, kubandakanywa imida yobumdaka, isinyithi esinzima, kunye nezinyibilikisi ezishiyekileyo.

Ngokubanzi, i-CMC idlala indima ebalulekileyo kwimixube emininzi yamayeza kwaye isetyenziswa kwizicelo ezahlukeneyo zonyango. Ukuqina kwayo okugqwesileyo, ukuzinzisa, kunye neempawu zokuthambisa zenza ukuba ibe ngumxhasi oguquguqukayo onokusetyenziswa kuluhlu olubanzi lwemixube. Njengesithako esilawulwayo, iinkampani ezixuba amayeza zinokuthembela kwi-CMC ukuba ikhuseleke, isebenze, kwaye ikumgangatho ophezulu ekuqulunqweni kwayo.