I-cellulose ethers yiklasi yeepolymers eziguqulwayo ezisekelwe kwi-cellulose, ezisetyenziswa ngokubanzi kwishishini lamachiza ngenxa yeempawu zabo ezintle zomzimba kunye neekhemikhali. Iintlobo zayo eziphambili ziquka i-hydroxypropyl methylcellulose (HPMC), i-carboxymethyl cellulose (CMC) kunye ne-methyl cellulose (MC). Ezi ether ze-cellulose zinoluhlu olubanzi lwezicelo kumachiza, iipilisi ezigubungelayo, ii-capsules, amalungiselelo okukhululwa okuqhubekayo kunye namalungiselelo olwelo.
1. Ukusetyenziswa kwiipilisi kunye neepilisi
Kwiipilisi kunye namalungiselelo e-capsule, i-cellulose ethers idla ngokusetyenziswa njengezibophelelo, i-disintegrants kunye nezixhobo zokugqoka. Njengezibophelelo, zinokuphucula ukunamathela phakathi kwamasuntswana eziyobisi, ukwenzela ukuba iipilisi zenze isakhiwo esiqinileyo kunye nobunzima obufanelekileyo kunye nexesha lokuhlukana. I-cellulose ethers inokuphucula ukumanzi kunye nokunyanzeliswa kweziyobisi kunye nokukhuthaza ukubumba okufanayo.
Izibophelelo: Ngokomzekelo, i-HPMC njenge-binder inokusasazwa ngokulinganayo kumphezulu weengqungquthela zamachiza, ukubonelela ngokubambelela okufanayo ukuqinisekisa ukuba iipilisi zigcina imilo ezinzileyo ngexesha loxinzelelo.
I-Disintegrants: Xa i-cellulose ethers idumba emanzini, inokunyusa ngokufanelekileyo izinga lokuchithwa kweepilisi kwaye iqinisekise ukukhutshwa ngokukhawuleza kwamachiza. I-MC kunye ne-CMC, njenge-disintegrants, inokukhawulezisa ukuchithwa kwamacwecwe kwi-gastrointestinal tract kunye nokuphucula i-bioavailability yamachiza ngokusebenzisa i-hydrophilicity kunye neempawu zokuvuvukala.
Izinto zokugquma: I-ethers ze-cellulose ezifana ne-HPMC zikwasetyenziswa ngokuqhelekileyo kwiipilisi zokwaleka kunye ne-capsules. Umaleko wokugquma awukwazi ukugquma incasa embi yechiza kuphela, kodwa ukwabonelela ngomgangatho okhuselayo wokunciphisa ifuthe lokufuma kokusingqongileyo kuzinzo lweziyobisi.
2. Ukusetyenziswa kumalungiselelo okukhululwa okuzinzileyo
I-cellulose ethers idlala indima ephambili kumalungiselelo okukhululwa okuqhubekayo kwaye isetyenziselwa ukulawula izinga lokukhutshwa kwamachiza. Ngokulungelelanisa uhlobo, i-viscosity kunye nokugxininiswa kwe-cellulose ethers, oosokhemisti banokuyila ii-curves ezahlukeneyo zokukhutshwa kweziyobisi ukufezekisa ukulibaziseka kokukhululwa, ukukhululwa okulawulwayo okanye ukukhululwa okujoliswe kuyo.
Ii-agent zokukhululwa ezilawulwayo: I-cellulose ethers ezifana ne-HPMC kunye ne-EC (i-ethyl cellulose) zisetyenziswa njenge-ejenti yokukhululwa elawulwayo kwiipilisi zokukhululwa okuqhubekayo. Ziyakwazi ukunyibilika ngokuthe ngcembe emzimbeni ukuze zenze umaleko wejeli, ngaloo ndlela zilawula izinga lokukhutshwa kwechiza kunye nokugcina i-plasma yoxinzelelo lwechiza.
Izinto ze-Skeleton: Kwi-skeleton yamalungiselelo okukhululwa okuqhubekayo, i-cellulose ethers isasaza iyeza kwi-matrix ngokwenza isakhiwo sothungelwano ukulungelelanisa izinga lokuchithwa kweyeza. Ngokomzekelo, izinto ze-HPMC ze-skeleton zenza iigels xa zibonakaliswe emanzini, ukuthintela ukuchithwa ngokukhawuleza kwamachiza kunye nokufezekisa ulawulo lwexesha elide.
3. Ukusetyenziswa kumalungiselelo olwelo
I-cellulose ethers isetyenziswa ngokubanzi njengama-thickeners, ii-agent zokumisa kunye nezizinzi kumalungiselelo olwelo. Banokwandisa i-viscosity kunye nokuzinza kwamalungiselelo olwelo kunye nokuthintela iyeza ukuba lihlale okanye lihluthe ngexesha lokugcinwa.
Thickeners: Cellulose ethers (ezifana CMC) njengoko thickeners kunokonyusa viscosity yamalungiselelo ulwelo, ukuqinisekisa ukuhanjiswa efanayo kwezithako zamachiza, kunye nokuthintela ukusiwa kweziyobisi.
Ii-arhente zokumisa: I-HPMC kunye ne-MC zisetyenziswa njengee-arhente zokumisa kumalungiselelo olwelo ukuqinisekisa ukuba amasuntswana amisiweyo asasazwa ngokulinganayo kulo lonke ulungiselelo ngokwenza inkqubo ye-colloidal ezinzileyo yokuthintela ukwahlulwa kwezithako zeziyobisi.
I-Stabilizers: I-ethers ye-cellulose ingasetyenziselwa njenge-stabilizers ukuphucula iikhemikhali kunye nokuzinza komzimba kwamalungiselelo olwelo ngexesha lokugcinwa kunye nokwandisa ubomi beshelufu yamachiza.
4. Ezinye izicelo
Ukongezelela, i-cellulose ethers nayo isetyenziselwa ukulungiswa kwe-transdermal kunye namalungiselelo e-ophthalmic kwishishini lamachiza. Basebenza njengabadali befilimu kunye neziphuculi ze-viscosity kwezi zicelo zokuphucula ukubambelela kunye ne-bioavailability yamalungiselelo.
Amalungiselelo e-Transdermal: I-HPMC kunye ne-CMC zihlala zisetyenziselwa iifilimu ze-transdermal patches, eziphucula ukufakwa kwe-transdermal yamachiza ngokulawula ukuphuphuma kwamanzi kunye nesantya sokungena kwamachiza.
Amalungiselelo e-Ophthalmic: Kumalungiselelo e-ophthalmic, i-cellulose ethers isetyenziswa njenge-thickeners ukuphucula ukunamathela kweziyobisi zamehlo, ukwandisa ixesha lokuhlala kweziyobisi kwindawo ye-ocular, kunye nokuphucula umphumo wonyango.
Ukusetyenziswa okubanzi kwe-cellulose ethers kwishishini lamachiza livela kwiimpawu zabo ezibalaseleyo zomzimba kunye neekhemikhali, ezifana ne-biocompatibility efanelekileyo, ukunyibilika okulawulekayo kunye nokuguquguquka ukuhlangabezana neemfuno zamalungiselelo ahlukeneyo. Ngokukhetha ngokufanelekileyo kunye nokuphucula ii-ether ze-cellulose, iinkampani ezixuba amayeza zinokuphucula umgangatho kunye nokuzinza kwamalungiselelo amachiza kwaye zihlangabezane neemfuno zezigulane zokhuseleko kunye nokusebenza kwamachiza. Ngokuqhubela phambili okuqhubekayo kobuchwepheshe boxubo mayeza, amathuba okusetyenziswa kwe-cellulose ethers aya kuba banzi.
Ixesha lokuposa: Jul-12-2024