Okokuqala, isifinyezo sesiNgesi sezinto ezincedisayo
MC: Methyl cellulose
EC: i-ethyl cellulose
I-HPC: i-hydroxypropyl cellulose
I-HPMC: i-hydroxypropyl methylcellulose
ICAP: Iselulosi acetate phthalates
I-HPMCP: i-hydroxypropyl cellulose phthalates
I-HPMCAS: i-hydroxypropyl methyl cellulose acetate succinate
Cmc-na: I-sodium carboxymethyl cellulose
I-MCC: I-Microcrystalline cellulose
PVP: Povidone
I-PEG: i-polyethylene glycol
I-PVA: Utywala bePolyvinyl
Cms-na: isitashi se-sodium carboxymethyl
I-PVPP: I-povidone edibeneyo
CCNa: i-crosslinked sodium carboxymethyl cellulose
Okwesibini, ukusetyenziswa kwezinye izinto ezincedisayo
1. I-Lactose: i-tablet: i-filler, ngokukodwa i-powder tablet filler ngqo; Isitofu: umkhuseli lyophilized
2. I-Microcrystalline cellulose: ithebhulethi: i-powder icinezele ngokuthe ngqo i-tablet filler; "I-adhesive eyomileyo"; Iipilisi eziqulethe i-20% ye-microcrystalline cellulose isebenza njenge-disintegrators
3. I-Methyl cellulose: ithebhulethi: i-adhesive; I-arhente yokumisa: uncedo lokumisa; Ukulungiselela ukukhutshwa okucothayo (okulawulwayo): imathiriyeli ye-hydrophilic gel skeleton (ebuthathaka)
I-4 ye-sodium carboxymethyl cellulose: iipilisi: i-adhesive; I-arhente yokumisa: uncedo lokumisa; Ukulungiswa kokukhululwa okucothayo (okulawulwayo): i-hydrophilic gel skeleton material
5. I-Ethyl cellulose: ithebhulethi: i-adhesive (i-insoluble emanzini); Ukulungiswa kokukhululwa okucothayo (okulawulwayo): i-skeleton material okanye i-membrane elawulwayo; Ukusasazwa okuqinileyo: Isixhobo sokuthwala esinganyibilikiyo
I-6 i-cellulose ye-hydroxypropyl: ithebhulethi: i-adhesive, ifilimu yezinto eziphathekayo; I-arhente yokumisa: uncedo lokumisa; Ukulungiswa okucothayo (okulawulwayo) okukhuphayo: imathiriyeli ye-hydrophilic gel skeleton, i-microporous inwebu egqunywe nge-sheet-inducing agent.
7. I-Hydroxypropyl methyl cellulose (i-hydroxypropyl methyl cellulose) : ithebhulethi: i-adhesive, ifilimu yokugqoka impahla; I-arhente yokumisa: uncedo lokumisa; Ukulungiswa okucothayo nokulawulwayo okukhuphayo: imathiriyeli ye-hydrophilic gel skeleton, i-microporous membrane egqunywe nge-sheet-inducing agent.
8. I-Cellulose acetate phthalates: izinto ze-enteric
9. I-Hydroxypropyl cellulose phthalates: izinto ze-enteric
10. I-Hydroxypropyl cellulose acetate succinate: izinto ze-enteric
11. I-Polyvinyl phthalate (PVAP) : izinto ze-enteric
12. I-Styrene Maleic acid copolymer (StyMA): imathiriyeli enyibilikayo emathunjini
13. I-Acrylic resin (uhlobo lwe-enteric I, II, III), i-Eudragit L, i-Eudragit S (ngamanye amaxesha i-Eudragit L100 okanye i-Eudragit S 100) : izinto ze-enteric
14.Eudragit RL, Eudragit RS: : Izinto zokuthwala ezinganyibilikiyo
15.Eudragit E (elingana ne-acrylic IV) : imathiriyeli yepolymer enyibilikayo esiswini
16. I-Cellulose acetate: imathiriyeli enganyibilikiyo yamanzi, ingasetyenziselwa ukugquma okanye ukulungisa iipilisi zempompo ze-osmotic.
17. I-Polyvinylpyrrolidone (i-povidone PVP) : iipilisi: i-adhesives; Ithebhulethi: i-gastric enyibilikayo yokugquma ifilimu; Iipilisi: i-nifedipine pellets (i-dispersion eqinile); I-arhente yokumisa: uncedo lokumisa;
I-Solid dispersion: izinto ezithwala amanzi ezinyibilikayo; Ukulungiswa kokukhululwa okucothayo (okulawulwayo): i-hydrophilic colloid skeleton material; Ukulungiswa kokukhululwa okucothayo (okulawulwayo): i-pore-inducing agent kwi-microporous membrane coated tablets
18. Utywala bePolyvinyl: i-agent yefilimu: izinto zokwenza ifilimu, uncedo lokumiswa
19. I-sodium carboxymethyl isitashi: ithebhulethi: i-agent edibeneyo
20. I-povidone edibeneyo: Ithebhulethi: i-disintegrant
21. I-Crosslinked sodium carboxymethyl cellulose: ithebhulethi: i-agent edibeneyo
22. I-cellulose ye-hydroxypropyl ephantsi endaweni ephantsi: Ithebhulethi: i-disintegrant
23. I-Polylactic acid: i-biodegradable polymer material, esetyenziselwa ukulungiswa kwe-microspheres, i-nanoparticles, njl.
24. I-Glycerol (i-sorbitol propylene glycol isebenza ngokusondeleyo kwi-glycerol)
Amalungiselelo olwelo: isinyibilikisi, isinyibilikisi senaliti, uncedo lokumiswa, isinyibilikisi
Iplastiki kwi-capsule kunye nezinto zokugqoka
Amafutha, iinkqubo zokuhanjiswa kwe-transdermal: abagqugquzeli bokungena
Ukwandisa ukumanzisa kweziyobisi ze-hydrophobic, isilawuli soxinzelelo lwe-osmotic kwi-emulsion ye-intravenous fat.
I-gelatin ye-Glycerin (yezithambiso, i-suppositories, i-dispersions eqinile)
25. I-gelatin ye-Glycerin
Iipilisi zokulahla: i-matrix yamanzi e-soluble
Suppository: imatrix enyibilikayo emanzini
I-ointment: Imatrix enyibilikayo yamanzi
26. I-sodium dodecyl sulfate (i-anionic surfactant)
I-emulsions, i-ointments: i-emulsifiers
I-agent yokumanzisa ukulungiselela okuqinileyo / i-lubricant yeepilisi
isinyibilikisi
27. Polyethylene glycol (PEG)
Amacwecwe: I-lubricant enyibilikayo emanzini (PEG 4000, 6000)
IThebhulethi: I-Plasticizer kumyalelo wokugquma ifilimu
I-Capsule: I-capsule ethambileyo engekho-oyile medium (PEG 400)
Iipilisi zokulahla: I-matrix enyibilikayo yamanzi (PEG 4000, 6000,9300)
Suppository: suppository matrix
I-aerosol: Isinyibilikisi esiLatent (PEG 400, 600)
Isitofu: Isinyibilikisi (PEG 400, 600)
Ukulungiswa kolwelo: Isinyibilikisi (PEG 400, 600)
Ukusasazeka okuqinileyo: umthwali
Ukulungiswa kokukhululwa okucothayo (okulawulwayo): i-pore-inducing agent kwi-microporous membrane coated tablets
Ukulungiswa kokufunxa nge-Percutaneous: i-transdermal absorption enhancer
28. I-Poloxam (” zwitterionic “surfactant) Iqabane elinononophelo liqaphele ukungafani apha, ngoku kulungiswe ukuya” Poloxam “i-non-ionic surfactant, hayi i-zwitterionic surfactant!
Umthwali we-Dispersion oqinileyo, i-suppository matrix, i-emulsifier yenaliti okanye ukufakwa
Isishwankathelo se-antiseptic kunye ne-bacteriostatic agents
IHydroxyl benzene ester (neper gold), benzoic acid, sodium benzoate, sorbic acid, benzalkonium bromide (new clean out), benzalkonium chloride (jie er die), chlorhexidine acetate, benzyl alcohol (intlungu yendawo) ngaxeshanye, idibene kunye ne-tertiary butyl alcohol (intlungu yendawo) ngexesha elifanayo, i-nitrobenzene, i-mercury, i-thimerosal, i-disinfection net, i-ortho-phenyl phenol, i-phenoxyethanol, i-oyile ye-eucalyptus, ioli ye-cinnamon, i-peppermint oil, njl.
Isine, indlela yokuvala inzala
I-1/Inaliti yeGlucose, i-fat emulsion yenaliti ye-intravenous, i-dextran, i-sodium chloride infusion, iplagi yerabha kunye nokunye ukucofa inzalo eshushu;
2/ Inaliti ye-Vitamin C, inaliti ye-procaine hydrochloride, inaliti ye-cortisone acetate, amathontsi e-chloramphenicol esweni aye acolwa ngokujikeleza umphunga;
I-3/ I-oyile yokujova, i-matrix yegrisi, i-ampoule isebenzisa indlela yokushisa ubushushu obumileyo;
I-4 / i-Asepsis yegumbi lomoya, indawo yetafile yokusebenza: indlela ye-ultraviolet sterilization okanye indlela yokutshisa igesi;
I-5/ Isandla, izixhobo ze-aseptic: indlela yokwenza iikhemikhali
I-6/ Isitofu se-insulin kunye nezinye iimveliso zebhayoloji: indlela yokucoca inzala
V. Ii-equations ezinxulumeneyo
1. I-Noyes-whitney equation: ichaza izinga lokuchithwa kwamachiza aqinileyo.
2. Ukufuma okubalulekileyo komxube
i-hygroscopicity ye-P68 powder)
3. Ixabiso lokutshintshwaisifakelo P87)
4.Ifomula yePoiseuile: chaza izinto ezichaphazelayo zokuhluza (i-injection P124)
5. Ifomula yokubala yolawulo lwe-isotonic ngendlela yokuthoba indawo yokukhenkcezainaliti P156)
6. Ukubalwa kwexabiso le-HLB le-surfactant edibeneyoulwelo P178)
Itekhnoloji yokulungiselela efanelekileyo
1. I-Microcapsule: indlela ye-condensation (eyodwa, eyinkimbinkimbi), indlela ye-solvent-non-solvent, indlela yokutshintsha ubushushu, indlela yokumisa ulwelo, indlela yokutshiza, indlela yokutshiza, indlela yokumisa umoya, indlela yokudibanisa i-interface, indlela yokudibanisa i-radiation crosslinking.
2. Ikhompawundi edityanisiweyo: indlela yesisombululo samanzi esigcwele amanzi, indlela yokugaya, indlela yokumisa umkhenkce, indlela yokutshiza yokumisa.
3. I-Dispersions eziqinileyo: indlela yokunyibilika, indlela yokunyibilikisa, indlela yokunyibilikisa - indlela yokunyibilikisa, isinyibilikisi - indlela yokutshiza yokumisa, indlela yokusila
4. ILiposomes: indlela yokutofa, indlela yokusasaza ifilimu ebhityileyo, indlela yokusasazwa kwe-ultrasonic, indlela yokubuyela umva yokuphuma komphunga, indlela yokumisa yomkhenkce.
5. I-Microspheres: i-emulsification - indlela yokunyanga, indlela yokumisa isitshizi, indlela yokomisa ulwelo
6. Nanoparticles: i-micellar polymerization, i-emulsion polymerization, i-interfacial polymerization, indlela yokomisa ulwelo
7. I-Pellet: indlela yokubilisa igranulation, indlela yokutshiza yegranulation, indlela yokugquma imbiza, indlela ye-extrusion sphericity, indlela ye-centrifugal projectile, indlela yokomisa ulwelo.
8 suppository: indlela yokunyibilika eshushu, indlela yokucinezela ebandayo, indlela yokuxova
9. I-ointment: indlela yokugaya, indlela yokunyibilika, indlela ye-emulsification
I-agent yefilimu ye-10: indlela yokwenza ifilimu edibeneyo ye-homogenized slurry, indlela yokwenza ifilimu yokunyibilikisa uxinzelelo, indlela yokwenza ifilimu edibeneyo
Isixhenxe, izixhobo ezimele
1. I-Microcapsule: i-gelatin - i-gum yesiArabhu
2. Ikhompawundi yokubandakanywa: i-cyclodextrin
3. Ukusasazwa okuqinileyo: PEG, PVP
4. I-Liposomes: i-phospholipid-cholesterol
5. IiMicrospheres: i-gelatin, i-albumin, i-PLA, njl
6. I-Sppository: ibhotela ye-cocoa
7. I-Ointment: i-petroleum jelly, njl
I-arhente yefilimu ye-8: i-PVA
Esibhozo, amaxesha ambalwa
1. I-ampoule enentsholongwane iya kushiywa ngaphandle kweeyure ezingama-24;
2. Ukugcinwa kwamanzi okutofwa akusayi kudlula iiyure ezili-12;
3. Ukuvalwa kweenaliti ngokubanzi kuya kugqitywa kwiiyure ezili-12 emva kokubunjwa;
4. Ukufakwa kunye nokulungiswa kwesisombululo kuya kugqitywa kwiiyure ezi-4 zokuvala inzala
9. Izinto zokuhlolwa komgangatho ezinxulumene namalungiselelo amayeza
1. Amacwecwe: iimpawu zembonakalo; Umahluko wobunzima beqhekeza; Ukuqina kunye nokuqina; Idigri yokwahlukana; Ukuchithwa okanye ukukhululwa; Ukufana komxholo
2. I-arhente yokusabalalisa: ukufana; Ukufuma. Ilayisha umahluko wobungakanani; Uvavanyo lwezempilo; Ukuhlolwa kwegranularity
3. Igranule: imbonakalo; Ubungakanani besuntswana; Ukuncipha kobunzima okomileyo; Nyibilika; Umahluko womthwalo
4. I-Capsule: ukubonakala; Ukufuma. Ilayisha umahluko wobungakanani; Ukuqhekeka kunye nokutshatyalaliswa.
5. Iipilisi zokulahla: umahluko wobunzima; Ukutshatyalaliswa kwexesha lokuhlola umda, njl.
6. Suppository: imbonakalo; Umahluko kubunzima; Ixesha lokunyibilikisa; Uluhlu lwamanqaku okunyibilika; Uvavanyo lokuchithwa kwe-in vitro kunye novavanyo lokufunxa kwi-vivo
7. I-Plaster: ubukhulu be-particle; Umthwalo; umda weMicrobial; Umxholo weziyobisi ophambili; Iimpawu zomzimba; Isivuseleli; Uzinzo; Ukukhutshwa, ukungena kunye nokufunxwa kweziyobisi kwi-ointment.
8. Iziqwenga zeTransdermal: umahluko wobunzima; Umahluko wendawo; Ukufana komxholo; Idigri yokukhutshwa, njl.
10. Iingcaciso ezahlukeneyo
1. I-Micro capsule: yi-capsule encinci eyenziwe ngokugubungela ichiza eliqinileyo okanye elimanzi (elibizwa ngokuba yi-capsule core) kwizinto zendalo okanye ezenziwe nge-polymer (ebizwa ngokuba yi-capsule material). 1-5000 microns
2. I-Pellet: ibhekisa kwiqumrhu elingqukuva elinobubanzi obungaphantsi kwe-2.5mm elenziwe ngamachiza kunye nezinto ezincedisayo.
3. I-Microsphere: i-skeleton-type microscopic entity spherical entity eyenziwe ngokuchithwa okanye i-dispersive drugs in the framework of polymer materials, kunye ne-particle size ngokuqhelekileyo phakathi kwe-1 kunye ne-250μm.
4. I-Nanoparticles: iincinci ze-colloidal eziqinileyo ezenziwe ngezinto ze-polymeric, ezinobungakanani be-particle kuluhlu lwe-10 ~ 1000nm.
5. I-ejenti yepilisi yokulahla: ibhekisela kumachiza aqinileyo okanye angamanzi kunye nezinto ezifanelekileyo (ngokuqhelekileyo ezaziwa ngokuba yi-matrix) umxube wokufudumeza ukunyibilika, uphonsa kwi-condensate edibeneyo, ukudibanisa kunye nokulungiswa kwe-pellet encinci.
Ixesha lokuposa: Sep-09-2022