Ngaba i-HPC kunye ne-HPMC ziyafana?

I-HPC (i-Hydroxypropyl Cellulose) kunye ne-HPMC (i-Hydroxypropyl Methylcellulose) zi-derivatives ze-cellulose ezinyibilikayo ezimbini ezisetyenziswa ngokuqhelekileyo kumashishini amayeza, ukutya kunye neekhemikhali. Nangona ziyafana kwezinye iinkalo, izakhiwo zazo zeekhemikhali, iipropati kunye neemeko zokusetyenziswa zihluke kakhulu.

1. Ubume beMichiza
I-HPC: I-HPC iyinxalenye ye-hydroxypropylated evela kwiselulosi. Yenziwe ngokuphendula i-cellulose ngepropylene oxide kunye nokwazisa amaqela e-hydroxypropyl (-CH2CHOHCH3). Kwisakhiwo se-HPC, inxalenye yamaqela e-hydroxyl ye-cellulose backbone ithathelwa indawo ngamaqela e-hydroxypropyl, okwenza i-soluble yamanzi kunye ne-thermoplastic.
I-HPMC: I-HPMC iyinxalenye ye-hydroxypropylated kunye ne-methylated derivative ye-cellulose. Ilungiselelwe ngokuzisa amaqela e-hydroxypropyl kunye namaqela e-methoxy (-OCH3) kwi-cellulose. Ubume bemolekyuli ye-HPMC inzima ngakumbi, kunye nokwaziswa kwamaqela e-hydroxypropyl kunye nokutshintshwa kwe-methyl.

2. Iimpawu zomzimba kunye neekhemikhali
Ukunyibilika: Zombini ziipolymers ezinyibilikayo emanzini, kodwa iindlela zabo zokuziphatha zokunyibilika zahlukile. I-HPC ine-solubility efanelekileyo emanzini abandayo kunye nezinye i-solvents eziphilayo (ezifana ne-ethanol, i-propanol, njl.), kodwa ukunyibilika kwayo kunokuncipha kumaqondo aphezulu (malunga ne-45 ° C okanye ngaphezulu). I-HPMC ine-solubility egqwesileyo emanzini abandayo, kodwa ineempawu ze-gelling emanzini aphezulu obushushu, oko kukuthi, ubushushu obuphezulu, i-HPMC echithwe emanzini iya kwenza ijeli kwaye ayiyi kuphinda inyibilike.
Ukuzinza kwe-Thermal: I-HPC ine-thermoplasticity efanelekileyo, oku kuthetha ukuba inokuthamba okanye inyibilike kumaqondo obushushu aphezulu, ngoko isoloko isetyenziswa kwizinto zokubumba ze-thermoplastic. I-HPMC inokumelana nobushushu obuphezulu, akukho lula ukunyibilika okanye ukuthamba, kwaye ikulungele ukusetyenziswa phantsi kweemeko eziphezulu zobushushu.
I-Viscosity: I-HPMC idla ngokuba ne-viscosity ephezulu kune-HPC, ngakumbi kwishishini lamachiza, i-HPMC isoloko isetyenziselwa ukwakheka okudinga ukudibanisa okuqinileyo okanye ukugquma, ngelixa i-HPC isetyenziswe kwiimeko apho kufuneka i-viscosity ephakathi okanye ephantsi.

3. Iinkalo zesicelo
Indawo yoXhobo:
I-HPC: I-HPC yi-excipient ye-pharmaceutical, ikakhulu isetyenziswa njenge-tablet enamathelayo, i-capsule shell film-forming agent, kunye ne-matrix material yokukhutshwa okulawulwayo kwamachiza. Ngenxa ye-thermoplasticity, ikwafanelekile kumalungiselelo athile enkqubo yokunyibilika eshushu. I-HPC ikwanayo ne-biocompatibility elungileyo kunye nokuthotywa, kwaye ikulungele ukusetyenziswa njengenkqubo yokuhanjiswa kweziyobisi kwi-intraoral.
I-HPMC: I-HPMC isetyenziswa kakhulu kushishino lwamayeza, kwaye isoloko isetyenziswa njengemathiriyeli ye-matrix, imathiriyeli yokugquma, i-thickener kunye nezinzisi kwiipilisi ezikhutshwa ngokuzinzileyo. Iimpawu ze-gelling ze-HPMC zenza ukuba ibe yinto efanelekileyo yokulawula ukukhutshwa kwechiza, ngokukodwa kwi-gastrointestinal tract, apho inokulawula ngokufanelekileyo izinga lokukhutshwa kwechiza. Iimpawu zayo ezilungileyo zokwenza ifilimu nazo zenza ukuba kube yinto ekhethiweyo yokugqoka i-tablet kunye ne-particle coating.

Indawo yokutya:
I-HPC: Kwishishini lokutya, i-HPC ingasetyenziswa njenge-thickener, stabilizer kunye ne-emulsifier ukuphucula ukuthungwa kunye nokubonakala kokutya. Kwiimeko ezithile, inokusetyenziswa njengesixhobo sefilimu enokutyiwa kokunye ukutya ekufuneka kugcinwe kumanzi okanye kwadwa.
I-HPMC: I-HPMC ikwasetyenziswa ngokuqhelekileyo njenge-thickener, emulsifier and stabilizer kushishino lokutya, ingakumbi kwizinto ezibhakwayo ezifana nesonka kunye neepastries. I-HPMC inceda ukuphucula ubume kunye nokuthungwa kwentlama kunye nokwandisa ubomi beshelufu yokutya. Ukongeza, i-HPMC ikwasetyenziswa ngokubanzi ekutyeni kwemifuno njengendawo esekwe kwisityalo endaweni ye-collagen yezilwanyana.
Izinto zokuthambisa kunye neemveliso zokhathalelo lomntu:

Zombini i-HPC kunye ne-HPMC zinokusetyenziswa kwizinto zokuthambisa njengezityebi, izinzisi kunye nabasunguli befilimu. Ngokomzekelo, zingasetyenziselwa ukunakekelwa kwesikhumba kunye nemveliso yeenwele ukuphucula umnxeba kunye nokuzinza kwemveliso. I-HPMC idla ngokufaneleka ngakumbi njenge-arhente ye-colloid ecacileyo, efana ne-thickener kumathontsi esweni, ngelixa i-HPC isoloko isetyenziswa kwiimeko apho kufuneka kwenziwe ukutyabeka okuguquguqukayo.
Izinto zokwakha kunye neengubo:

I-HPMC: Ngenxa yokubambelela kakuhle kunye nokugcinwa kwamanzi, i-HPMC isetyenziswa ngokubanzi kwizinto zokwakha ezifana nesamente, udaka, i-putty kunye negypsum ukunyusa ukunamathela kunye nokuphucula ukusebenza kokwakha.
I-HPC: Ngokwahlukileyo, i-HPC ayisetyenziswanga kangako kushishino lokwakha kwaye isoloko isetyenziswa njenge-additive okanye i-adhesive for the coatings.

4. Ukhuseleko kunye nokukhuselwa kwendalo
Zombini i-HPC kunye ne-HPMC zithathwa njengezixhobo ezikhuselekileyo kwaye zisetyenziswa kakhulu ekutyeni, kumayeza nakwiimveliso zokhathalelo lomntu. Zombini zine-biocompatibility entle kunye nokuthotywa, kwaye aziyi kubangela iziphumo ebezingalindelekanga ezinetyhefu kumzimba womntu. Nangona kunjalo, kuba azifakwanga emzimbeni womntu kwaye zisetyenziswa kuphela njengezinto ezincedisayo, zihlala zingenazo iziphumo zenkqubo kumzimba womntu. Ukongeza, inkqubo yokuvelisa i-HPC kunye ne-HPMC ihambelana nokusingqongileyo, kwaye iikhemikhali kunye nezinyibilikisi ezisetyenziswa kwimveliso zinokuphinda zisetyenziswe kwaye zisetyenziswe kwakhona.

Nangona i-HPC kunye ne-HPMC zombini i-cellulose derivatives kwaye ine-cross-applications kwezinye izicelo, inomahluko omkhulu kwisakhiwo sekhemikhali, iipropati zomzimba kunye neendawo zesicelo. I-HPC ifaneleka ngakumbi kwizicelo ezifuna izinto ze-thermoplastic, ezifana nokukhululwa kweziyobisi ezilawulwayo kunye neenkqubo zokubumba ezishushu ezinyibilikayo, ngelixa i-HPMC isetyenziswa ngokubanzi kumayeza, ukutya, ukwakhiwa kunye nezinye iindawo ngenxa yokubambelela kwayo kakuhle, iipropati zokwenza ifilimu kunye nokugcinwa kwamanzi. . Ngoko ke, yiyiphi impahla yokukhetha ixhomekeke kwiimfuno ezithile zesicelo.