I-Hydroxypropyl Methylcellulose (HPMC) yi-semi-synthetic, inert, i-polymer ephezulu ye-viscosity esetyenziswa ngokubanzi ekuqulunqweni kweziyobisi. Iimpawu zayo ezikhethekileyo zomzimba kunye neekhemikhali zenza ukuba ibe ngumxhasi oyimfuneko kwishishini lamayeza, ngokwenza ifilimu, ukuqina, uzinzo kunye ne-biocompatibility.
Iimpawu eziphambili zeHPMC
I-HPMC yenziwe nge-methylating kunye ne-hydroxypropylating cellulose. Inonyibiliko oluhle lwamanzi kunye ne-thermoplasticity, kwaye inyibilika ngokukhawuleza emanzini abandayo ukwenza isisombululo se-colloidal esicacileyo. I-solubility yayo kunye ne-viscosity inokulawulwa ngokulungelelanisa iqondo lokutshintshwa kunye neqondo le-polymerization, evumela i-HPMC ukuba ihlangabezane neemfuno zeendlela ezahlukeneyo zeyeza.
Iindawo zesicelo
1. Iziyobisi ezilawulwayo
I-HPMC isetyenziswa ngokubanzi ekulungiseleleni amachiza alawulwayo akhutshwayo. Ngenxa yokunyibilika kwayo emanzini kunye nokukwazi ukwenza iijeli, i-HPMC inokulawula izinga lokukhululwa kwamachiza. Iimpawu zayo zokudumba kwindlela yesisu zivumela ukuba ichiza likhutshwe ngokuthe ngcembe kwixesha elithile, ukulawula ngokufanelekileyo ukuxinwa kwe-plasma yeyeza, ukunciphisa ukuphindaphinda kwamayeza, kunye nokuphucula ukuthotyelwa kwesigulane.
2. Izibophelelo kunye ne-disintegrants kwiipilisi
Njengesibophelelo kunye ne-disintegrant yamacwecwe, i-HPMC inokuphucula amandla oomatshini beepilisi ngelixa iqinisekisa ukuba iipilisi ziyahlukana kwaye zikhulule izithako ezisebenzayo ngexesha elifanelekileyo. Iimpawu zayo zokubambelela zinceda ukubopha iinqununu zeziyobisi kunye nokwenza ithebhulethi eqinile, ngelixa iimpawu zayo zokuvuvukala zivumela iipilisi ukuba zidibanise ngokukhawuleza emanzini.
3. Iiarhente zokugquma ifilimu
I-HPMC sisixhobo esibalulekileyo sokulungiselela ukutyabeka kwefilimu yeziyobisi. Ingasetyenziswa njengokhuselo lokugquma ifilimu ukukhusela iyeza kumswakama, ioksijini kunye nokukhanya, ngaloo ndlela kuphuculwe ukuzinza kweziyobisi. Ukongeza, i-HPMC ingasetyenziswa njenge-enteric yokugquma ukukhusela ichiza ekukhutshweni esiswini kunye nokuqinisekisa ukuba ichiza lifakwe emathunjini.
4. Amalungiselelo e-Ophthalmic
Kumalungiselelo e-ophthalmic, i-HPMC isoloko isetyenziselwa ukulungisa iinyembezi ezenziweyo kunye namathontsi esweni. I-viscosity yayo ephezulu kunye ne-biocompatibility yenza ukuba yenze ifilimu ekhuselayo kumphezulu weso, ukuthambisa iliso, kunye nokukhulula iimpawu zamehlo ezomileyo.
5. Iipilisi
I-HPMC ingasetyenziselwa ukulungiselela ii-capsules ezinzima kunye nee-capsules ezithambileyo. Xa kuthelekiswa neecapsules zegelatin zemveli, iipilisi ze-HPMC zinozinzo olungcono lwekhemikhali, akulula ukufunxa ukufuma, kwaye zinobuhlobo ngakumbi kubantu abatya imifuno kunye namakholwa enkolo.
Imiba enempembelelo
1. I-Viscosity
I-viscosity ye-HPMC yenye yezibonakaliso ezibalulekileyo zokusebenza kwayo. I-HPMC ene-viscosity ephezulu ingasetyenziselwa ukukhutshwa kweziyobisi ezilawulwayo kunye namalungiselelo afakwe ifilimu, ngelixa i-HPMC ye-viscosity ephantsi ifaneleke ngakumbi ukuba isetyenziswe njenge-binder kunye ne-disintegrant.
2. Isidanga sokutshintshwa
Iqondo lokutshintshwa (DS) kunye nokutshintshwa kwe-molar (MS) ye-HPMC ichaphazela ngokuthe ngqo ukunyibilika kwayo kunye nokukwazi ukwenza i-gel. Ulungelelwaniso olufanelekileyo lweqondo lokutshintshwa kunokwandisa isiphumo sokusetyenziswa kwe-HPMC kwimixube eyahlukeneyo yamachiza.
3. Imiba yokusingqongileyo
Ukusebenza kwe-HPMC kukwachatshazelwa yimiba yokusingqongileyo efana nobushushu, ixabiso le-pH kunye namandla e-ionic. Le miba kufuneka iqwalaselwe xa kusenziwa imixube yamachiza ukuqinisekisa ukuba i-HPMC isebenza ngokupheleleyo.
I-Hydroxypropyl methylcellulose (HPMC), njenge-multifunctional, i-excipient ye-pharmaceutical excipient, isetyenziswa ngokubanzi kwiinkalo ezininzi ezifana nokukhutshwa okulawulwa ngamachiza, iipilisi, amalungiselelo afakwe ifilimu, amalungiselelo e-ophthalmic kunye nee-capsules. Ngokulungelelanisa i-viscosity yayo kunye neqondo lokutshintshwa, inokuhlangabezana neemfuno zeendlela ezahlukeneyo zeyeza kunye nokuphucula kakhulu ukuzinza kunye ne-bioavailability yamachiza. Ngokuqhubela phambili okuqhubekayo kobuchwepheshe boxubo mayeza, amathuba okusetyenziswa kwe-HPMC aya kuba banzi.
Ixesha lokuposa: Jul-11-2024