Iselulosi yeHydroxypropyl, i-excipient ye-pharmaceutical, ihlulwe ibe yi-low-substituted hydroxypropyl cellulose (L-HPC) kunye ne-high-substituted hydroxypropyl cellulose (H-HPC) ngokomxholo weqela layo le-hydroxypropoxyl. I-L-HPC ihluma kwisisombululo se-colloidal emanzini, ineempawu zokubambelela, ukubunjwa kwefilimu, i-emulsification, njl., kwaye isetyenziswa kakhulu njenge-agent edibeneyo kunye ne-binder; ngelixa i-H-HPC inyibilika emanzini kunye nezinyibilikisi ezahlukeneyo zendalo kwiqondo lobushushu begumbi, kwaye ine-thermoplasticity elungileyo. , ubumbano kunye neempawu zokwenza ifilimu, ifilimu eyenziwe lukhuni, i-glossy, kwaye i-elastic epheleleyo, kwaye isetyenziswa kakhulu njengento yokwenza ifilimu kunye nempahla yokugubungela. Ukusetyenziswa okuthe ngqo kwe-hydroxypropyl cellulose kumalungiselelo aqinileyo ngoku kwaziswa.
1. Njenge-disintegrant yamalungiselelo aqinileyo afana neepilisi
Umphezulu we-low-substituted hydroxypropyl cellulose crystalline particles ayilingani, kunye nesakhiwo esicacileyo esifana nelitye. Esi sakhiwo somhlaba esirhabaxa asenzeli nje ukuba sibe nommandla omkhulu womphezulu, kodwa naxa sixinaniswe kwithebhulethi kunye neziyobisi kunye nezinye izinto ezincedisayo, iipores ezininzi kunye neecapillaries zenziwa kumbindi wethebhulethi, ukuze i-tablet core inokunyusa ukufuma. izinga lokufunxa kunye nokufunxa Amanzi kwandisa ukudumba. Ukusebenzisa i-L-HPC njenge-excipient ingenza i-tablet idibanise ngokukhawuleza ibe ngumgubo ofanayo, kwaye iphucule kakhulu ukuchithwa, ukuchithwa kunye ne-bioavailability ye-tablet. Ngokomzekelo, ukusetyenziswa kwe-L-HPC kunokukhawulezisa ukuchithwa kweepilisi ze-paracetamol, iipilisi ze-aspirin, kunye neepilisi ze-chlorpheniramine, kunye nokuphucula izinga lokuchithwa. Ukutshatyalaliswa kunye nokutshatyalaliswa kwamachiza angenakunyibilika kakubi afana neepilisi ze-ofloxacin ezine-L-HPC njenge-disintegrants zazingcono kunezo zine-PVPP edibeneyo, i-CMC-Na kunye ne-CMS-Na njenge-disintegrants. Ukusebenzisa i-L-HPC njenge-disintegrant yangaphakathi ye-granules kwii-capsules kunenzuzo ukuchithwa kwe-granules, kwandisa indawo yoqhagamshelwano phakathi kweziyobisi kunye ne-medium dissolution, ikhuthaza ukuchithwa kweyeza, kwaye iphucula i-bioavailability. Amalungiselelo aqinileyo akhutshwa ngokukhawuleza amelwe kukuqhekeka kwamalungiselelo aqinileyo kunye namalungiselelo aqinileyo adityanisiweyo ngokukhawuleza anokuqhekeka ngokukhawuleza, ukunyibilika ngokukhawuleza, iziphumo ezikhawulezayo, i-bioavailability ephezulu, ukunciphisa ukucaphuka kweziyobisi kummizo kunye nomgudu wesisu, kwaye kulula ukuyithatha. kwaye ube nokuthotyelwa kakuhle. kunye nezinye iingenelo, ebambe indawo ebalulekileyo kwintsimi ekhemesti. I-L-HPC ibe yenye yezona zinto zibaluleke kakhulu kumalungiselelo aqinileyo okukhululwa kwangoko ngenxa ye-hydrophilicity yayo eyomeleleyo, i-hygroscopicity, ukwanda, ixesha elifutshane le-hysteresis lokufunxa amanzi, isantya sokufunxa amanzi ngokukhawuleza, kunye nokugcwala kwamanzi okukhawulezayo. Yinto efanelekileyo yokuchitha iipilisi eziqhekeza ngomlomo. Iipilisi zeParacetamol ezichithwa ngomlomo zalungiswa nge-L-HPC njenge-disintegrant, kwaye iipilisi zahlukana ngokukhawuleza ngaphakathi kwe-20s. I-L-HPC isetyenziswa njenge-disintegrant kwiipilisi, kwaye umthamo wayo jikelele yi-2% ukuya kwi-10%, ubukhulu becala yi-5%.
2. Njengesibophelelo samalungiselelo afana neepilisi kunye neegranules
Ubume oburhabaxa be-L-HPC buphinda bube nefuthe elikhulu le-mosaic kunye neziyobisi kunye namasuntswana, okwandisa iqondo lokubumbana, kwaye kunomsebenzi olungileyo wokubumba. Emva kokucinezelwa kwiipilisi, ibonisa ubunzima obuninzi kunye ne-gloss, ngaloo ndlela iphucula umgangatho wembonakalo yethebhulethi. Ngokukodwa kwiipilisi ezingelula ukwenza, zikhululekile okanye zilula ukuzityhila, ukongeza i-L-HPC kunokuphucula umphumo. I-tablet ye-ciprofloxacin hydrochloride inokunyanzeliswa kakubi, kulula ukuhlukana kunye nokunamathela, kwaye kulula ukwenza emva kokongeza i-L-HPC, ngobulukhuni obufanelekileyo, ukubonakala okuhle, kunye nesantya sokuchithwa sihlangabezana neemfuno ezisemgangathweni. Emva kokongeza i-L-HPC kwi-tablet echithwayo, ukubonakala kwayo, ukunyaniseka, ukufana kwe-dispersion kunye neminye imiba iphuculwe kakhulu kwaye iphuculwe. Emva kokuba isitashi kummiselo wokuqala satshintshwa yi-L-HPC, ukuqina kwethebhulethi ye-azithromycin echithwayo kwandiswa, ukuqina kwaphuculwa, kwaye iingxaki zeekona ezilahlekileyo kunye nemiphetho ebolileyo yethebhulethi yasonjululwa. I-L-HPC isetyenziswa njenge-binder kwiipilisi, kunye ne-dosage jikelele yi-5% ukuya kwi-20%; ngelixa i-H-HPC isetyenziswa njenge-binder kwiipilisi, iigranules, njl., kunye ne-dosage jikelele yi-1% ukuya kwi-5% yamalungiselelo.
3. Ukusetyenziswa kwi-coating yefilimu kunye nokugcinwa kunye nokulawulwa kwamalungiselelo okukhululwa
Okwangoku, izinto ezinyibilikayo zamanzi ezisetyenziswa ngokuqhelekileyo kwifilimu zibandakanya i-hydroxypropyl methylcellulose (HPMC), i-hydroxypropyl cellulose, i-polyethylene glycol (PEG), njl. , ifilimu elastiki kunye necwebezelayo. Ukuba i-cellulose ye-hydroxypropyl ixutywe kunye nezinye ii-agent ezikwazi ukumelana nobushushu, ukusebenza kwengubo yayo kunokuphuculwa ngakumbi.
Ukusebenzisa izixhobo ezifanelekileyo kunye nobuchule bokwenza ichiza libe ziipilisi ze-matrix, iipilisi ezidadayo esiswini, iipilisi ezinomaleko amaninzi, iipilisi ezigqunyiweyo, iipilisi zempompo ze-osmotic kunye nezinye iipilisi zokukhupha ezicothayo nezilawulwayo, ukubaluleka kulele koku: ukwandisa iqondo lokufunxa ichiza kunye nokuzinzisa iziyobisi. iyeza egazini. Ukugxila, ukunciphisa ukusabela okubi, ukunciphisa inani lamayeza, kunye nokuzama ukwandisa ukusebenza kakuhle ngedosi encinci, kunye nokunciphisa ukusabela okubi. I-Hydroxypropyl cellulose yenye yezinto eziphambili zamalungiselelo anjalo. Ukutshatyalaliswa kunye nokukhululwa kwamacwecwe e-sodium ye-diclofenac kulawulwa ngokusebenzisa i-hydroxypropyl cellulose kunye ne-ethyl cellulose njengento edibeneyo kunye ne-skeleton. Emva kokulawulwa komlomo kunye nokuqhagamshelana nejusi yesisu, umphezulu we-diclofenac sodium iipilisi zokukhululwa okuqhubekayo ziya kufakwa kwi-gel. Ngokuchithwa kwejeli kunye nokusasazwa kweemolekyuli zamachiza kwi-gap ye-gel, injongo yokukhululwa okucothayo kweemolekyuli zamachiza kufezekiswa. I-Hydroxypropyl cellulose isetyenziswa njenge-matrix elawulwayo yokukhutshwa kwethebhulethi, xa umxholo we-blocker ethyl cellulose uhlala rhoqo, umxholo wayo kwithebhulethi umisela ngokuthe ngqo izinga lokukhululwa kweyeza, kunye neyeza elivela kwithebhulethi enomxholo ophezulu. ye-hydroxypropyl cellulose Ukukhutshwa kuhamba kancinci. Iipelisi ezigqunyiweyo zalungiswa ngokusebenzisa i-L-HPC kunye nomlinganiselo othile we-HPMC njengesisombululo sokugquma ukugquma njengomaleko wokudumba, kwaye njengoluhlu olulawulwayo lokukhutshwa kwe-ethyl cellulose dispersion aqueous. Xa i-rescription layer yokuvuvukala kunye ne-dosage igxininisekile, ngokulawula ubuninzi bomgangatho wokukhululwa olawulwayo, iipelisi ezidibeneyo zinokukhutshwa ngamaxesha ahlukeneyo alindelekileyo. Iindidi ezininzi zeepellet ezigqunyiweyo ezinobunzima obahlukeneyo bomaleko wokukhutshwa olawulwayo zixutywe ukwenza iShuxiong iicapsules zokukhululwa okuqhubekayo. Kwindawo yonyibiliko, iipellets ezahlukeneyo ezigqunyiweyo zinokukhupha amachiza ngokulandelelana ngamaxesha ahlukeneyo, ukuze amacandelo aneempawu ezahlukeneyo zomzimba kunye neekhemikhali Ukukhutshwa ngaxeshanye kuphunyeziwe ngelixa ukukhululwa okuqhubekayo.
Ixesha lokuposa: Jan-28-2023