1. Intshayelelo kwi-HPMC
I-Hydroxypropyl Methylcellulose (HPMC) yi-ether ye-cellulose engekho ionic esetyenziswa ngokubanzi kwizinto zokwakha, iingubo, amayeza, izimonyo, ukutya kunye nezinye iindawo. Ngenxa yokunyibilika kakuhle kwamanzi, i-gelling kunye neempawu zokuqina, i-HPMC isoloko isetyenziswa njenge-thickener, i-stabilizer kunye ne-gelling agent. I-solubility yamanzi ye-HPMC yenye yeempawu zayo eziphambili kwizicelo eziphathekayo, kodwa ixesha lokuchithwa kwayo liyahluka ngenxa yezinto ezininzi.
2. Inkqubo yokuchithwa kwe-HPMC
I-HPMC inonyibiliko oluhle lwamanzi, kodwa ngexesha lenkqubo yonyibiliko, kufuneka ifunxe amanzi kwaye idumbe kuqala, ize inyibilike ngokuthe ngcembe. Le nkqubo idla ngokwahlulwa ngokwezigaba ezilandelayo:
Ukufunxwa kwamanzi kunye nokudumba: I-HPMC ifunxa amanzi kuqala emanzini, kwaye iimolekyuli zeselulosi ziqala ukudumba.
Ukuxuba ukusasazwa: I-HPMC isasazwe ngokulinganayo emanzini ngokushukumisa okanye ezinye iindlela zoomatshini ukunqanda ukuhlangana.
Ukuchithwa ukwenza isisombululo: Ngaphantsi kweemeko ezifanelekileyo, iimolekyuli ze-HPMC ngokuthe ngcembe zityhila kwaye zinyibilike emanzini ukuze zenze isisombululo esizinzileyo se-colloidal.
3. Ixesha lokuchithwa kwe-HPMC
Ixesha lokuchithwa kwe-HPMC alilungiswanga, lidla ngokuqala kwimizuzu eli-15 ukuya kwiiyure ezininzi, kwaye ixesha elikhethekileyo lixhomekeke kwezi zinto zilandelayo:
Uhlobo kunye nebakala le-viscosity ye-HPMC: I-molecular weight and viscosity grade ye-HPMC inefuthe elibalulekileyo kwixesha lokuchithwa. I-HPMC ene-viscosity ephezulu ithatha ixesha elide ukunyibilika, ngelixa i-HPMC ene-viscosity ephantsi inyibilika ngokukhawuleza. Umzekelo, i-4000 cps HPMC inokuthatha ixesha elide ukunyibilika, ngelixa i-50 cps HPMC inokupheliswa ngokupheleleyo malunga nemizuzu eyi-15.
Ubushushu bamanzi: Ubushushu yinto ebalulekileyo echaphazela ixesha lokuchithwa kwe-HPMC. Ngokuqhelekileyo, i-HPMC iya kufunxa amanzi kwaye idumbe ngokukhawuleza emanzini abandayo, kodwa inyibilike kancinane; emanzini ashushu (njengaphezulu kwama-60°C), i-HPMC iya kwenza imeko yethutyana enganyibilikiyo. Ke ngoko, "indlela yokuchithwa kwamanzi abandayo kunye namanzi ashushu kabini" yokuqala ukusasazwa ngamanzi abandayo kwaye emva koko ukufudumeza ngokuqhelekileyo kusetyenziselwa ukukhawulezisa inkqubo yokutshatyalaliswa.
Indlela yokuphelisa: Indlela yokuphelisa nayo inefuthe elikhulu kwixesha lokuchithwa kwe-HPMC. Iindlela eziqhelekileyo zokuchithwa ziquka ukuvuselela oomatshini, unyango lwe-ultrasonic okanye ukusetyenziswa kwezixhobo zokucheba ngesantya esiphezulu. Ukuvuselela oomatshini kunokunyusa ngokufanelekileyo izinga lokuchithwa, kodwa ukuba ayisetyenziswanga ngokufanelekileyo, kunokwenza amaqhuma kwaye kuchaphazele ukusebenza kakuhle kokutshatyalaliswa. Ukusebenzisa i-high-speed stirrer okanye i-homogenizer inokunciphisa kakhulu ixesha lokuchithwa.
Ubungakanani bamasuntswana e-HPMC: Amasuntswana amancinci, ngokukhawuleza isantya sokunyibilika. I-Fine-particle HPMC kulula ukuyichitha kwaye inyibilike ngokulinganayo, kwaye idla ngokusetyenziswa kwiimeko zesicelo kunye neemfuno eziphezulu zokuchithwa.
Isixa sokunyibilikisa: Nangona i-HPMC inyibilika ikakhulu emanzini, inokunyibilika kwezinye izinyibilikisi zendalo, ezinjengeethanol kunye nepropylene glycol nezisombululo zamanzi. Iinkqubo ezahlukeneyo zokunyibilikisa ziya kuchaphazela izinga lokuchithwa. Kwizinto ezinyibilikayo zendalo, ixesha lokuchithwa lide kakhulu kunelo lamanzi.
4. Iingxaki eziqhelekileyo kwinkqubo yokuchithwa kwe-HPMC
I-Agglomeration phenomenon: I-HPMC ithanda ukwenza amaqhuma xa inyibilikiswa emanzini, ngakumbi xa ubushushu bamanzi buphezulu okanye ukushukuma kunganelanga. Oku kungenxa yokuba umphezulu we-HPMC ufunxa amanzi kwaye wanda ngokukhawuleza, kwaye ingaphakathi ayikadibanisi namanzi, okukhokelela kwisantya esicothayo sokuchithwa kwezinto zangaphakathi. Ke ngoko, ekusebenzeni kokwenyani, ihlala isetyenziselwa ukucotha nangokulinganayo ukufefa iHPMC emanzini abandayo kuqala, kwaye uyishukumise ngokufanelekileyo ukuthintela ukudityaniswa.
Ukuchithwa okungagqibekanga: Ngamanye amaxesha isisombululo se-HPMC sibonakala sifana, kodwa ngokwenene inxalenye yeselulosi ayinyibiliki ngokupheleleyo. Ngeli xesha, kuyimfuneko ukwandisa ixesha lokuvuselela, okanye ukukhuthaza ukuchithwa ngokulawulwa kokushisa okufanelekileyo kunye neendlela zomatshini.
5. Lilenziwa njani ngokupheleleyo ixesha lokuchithwa kwe-HPMC
Sebenzisa indlela yokusasazwa kwamanzi abandayo: ufefe ngokucothayo i-HPMC emanzini abandayo ukunqanda ukuhlangana okubangelwa kukufunxwa kwangoko kunye nokwandiswa kwamanzi. Emva kokuba i-HPMC ihlakazwe ngokupheleleyo, yifudumeze ibe yi-40-60°C ukukhuthaza ukuchithwa ngokupheleleyo kwe-HPMC.
Ukukhethwa kwezixhobo ezishukumisayo: Kwimiboniso eneemfuno zesantya esiphezulu sokuchithwa, unokukhetha ukusebenzisa i-high speed mixers yokucheba, i-homogenizers kunye nezinye izixhobo zokunyusa izinga lokuvuselela kunye nokusebenza kakuhle kunye nokunciphisa ixesha lokuchithwa.
Control lobushushu: Ulawulo lobushushu ngundoqo ukunyibilika HPMC. Kuphephe ukusebenzisa amanzi ashushu ngeqondo lobushushu eliphezulu kakhulu ukunyibilika HPMC ngqo, kodwa sebenzisa ukusasazwa kwamanzi abandayo kwaye ke ukufudumeza. Kwiimeko ezahlukeneyo zesicelo, unokukhetha ubushushu obufanelekileyo bokupheliswa ngokweemfuno zakho.
Ixesha lokuchithwa kwe-HPMC yinkqubo eguquguqukayo echatshazelwa yimiba emininzi. Ngokuqhelekileyo, ixesha lokuchithwa kwemizuzu eyi-15 ukuya kwiiyure ezininzi liqhelekileyo, kodwa ixesha lokuchithwa lingancitshiswa kakhulu ngokulungisa indlela yokutshatyalaliswa, isantya esishukumisayo, ubungakanani besuntswana kunye nokulawula ubushushu.
Ixesha lokuposa: Oct-25-2024