Ngophuhliso oluqhubekayo lweshishini lamayeza kunye nokuqhubela phambili kobuchwephesha bamayeza, imfuno yeefomu zedosi yamayeza nayo iyanda. Phakathi kweefom ezininzi zedosi, ii-capsules ziye zaba yifom yedosi esetyenziswa ngokubanzi kwishishini lamayeza ngenxa ye-bioavailability entle kunye nokuthotyelwa kwesigulane. Kwiminyaka yakutshanje, i-HPMC (hypromellose) i-capsules engenanto ngokuthe ngcembe ithathe indawo ebalulekileyo kwimveliso yamayeza ngenxa yeenzuzo zabo ezibalulekileyo.
(1) Isishwankathelo esisisiseko se-HPMC yee-capsules ezingenanto
I-HPMC, okanye i-hypromellose, yikhompawundi eyenziwe ngokwendalo yepolymer edla ngokufunyanwa kwintlama yeplanga okanye kwifayibha yomqhaphu ngothotho lonyango lwekhemikhali. Ulwakhiwo olulodwa lwe-HPMC lunika iipropati ezibalaseleyo zomzimba kunye neekhemikhali, ezifana nokucaca okuphezulu, amandla okusebenza kakuhle, ukunyibilika okuzinzileyo, kunye ne-viscosity efanelekileyo. Ezi propati zenza i-HPMC isetyenziswe ngokubanzi kwiinkalo ezininzi, ngakumbi kwintsimi yamachiza.
(2) Iinzuzo eziphambili ze-HPMC ii-capsules ezingenanto
1. Imvelaphi yezityalo kunye nokuhambelana kwemifuno
Imathiriyeli ekrwada ye-HPMC yee-capsules ezingenanto iphuma ikakhulu kwifayibha yezityalo, eyenza ibe lolona khetho lufanelekileyo kubantu abatya imifuno. Ngokungafaniyo neekhepsuli zegelatin zemveli, ii-capsules ezingenanto ze-HPMC aziqulathanga izithako zezilwanyana, ngoko ke imfuno yazo yentengiso ikhula ngokukhawuleza kwiindawo ezinothintelo olungqongqo lwemifuno, yenkolo okanye yenkcubeko. Le nzuzo ayihambelani kuphela neenkxalabo zabathengi banamhlanje malunga nempilo kunye nokukhuselwa kwendalo, kodwa ikwabonelela ngenkxaso eyomeleleyo kwiinkampani zamachiza ukwandisa imarike yehlabathi.
2. Ukuzinza kakuhle kweekhemikhali
Iicapsules ezingenanto ze-HPMC zizinzile kakhulu kwiimpawu zekhemikhali kwaye azichatshazelwa lula yimiba yokusingqongileyo efana nobushushu kunye nokufuma. Le propati inika inzuzo ebalulekileyo ngexesha lokugcinwa kunye nokuthutha. Ngokwahlukileyo koko, i-gelatin capsules ixhomekeke kwi-cross-linking reactions kwiqondo lokushisa eliphezulu kunye neendawo zokufuma eziphezulu, ezichaphazela ukunyibilika kunye ne-bioavailability yamachiza. I-HPMC ii-capsules ezingenanto zinokugcina ngcono izithako ezisebenzayo zechiza kwaye zandise ubomi beshelufu yechiza.
3. I-solubility egqwesileyo kunye ne-bioavailability
Iicapsules ezingenanto ze-HPMC zinesantya sokuchithwa ngokukhawuleza kunye nesantya esiphezulu sokufunxa emzimbeni womntu, evumela ukuba ichiza likhutshwe ngokukhawuleza emzimbeni kwaye lifezekise isiphumo esifanelekileyo sonyango. Ukunyibilika kwayo akuchatshazelwa kancinci ngexabiso le-pH yendawo engqongileyo kwaye kunokugcina izinga lokunyibilika elizinzileyo ngaphakathi koluhlu olubanzi lwe-pH. Ukongeza, ii-capsules ezingenanto ze-HPMC zinamathele ngokuqinileyo kwi-gastrointestinal tract, eququzelela ukufunxwa kweziyobisi zendawo kunye nokuphucula ngakumbi ukufumaneka kwamachiza.
4. Ukulungelelanisa uluhlu olubanzi lwezicelo kwiifom ezahlukeneyo zedosi
Ii-capsules ezingenanto ze-HPMC zinamandla amakhulu omatshini kwaye ziyakwazi ukulungelelanisa neemfuno zokuzaliswa kwesantya esiphezulu semigca yokuvelisa ngokuzenzekelayo kunye nokunciphisa ilahleko ngexesha lenkqubo yokuvelisa. Ukongeza, ii-capsules ezingenanto ze-HPMC zinokumelana noxinzelelo oluqinileyo kunye neempawu ezilungileyo zokutywinwa, ezinokuthintela ngokufanelekileyo amachiza ekubeni afume okanye afakwe i-oxidized. Ngenxa yokungathathi hlangothi kwee-capsules ezingenanto ze-HPMC, zihambelana neentlobo zezithako zamachiza kwaye zifanelekile kwiindlela ezahlukeneyo zedosi yamachiza, njengamalungiselelo aqinileyo, amalungiselelo olwelo, amalungiselelo angama-semi-solid, njl.
5. Nciphisa umngcipheko wokwaliwa
Enye inzuzo ebalulekileyo ye-HPMC ye-capsules engenanto yi-hypoallergenicity yabo. Xa kuthelekiswa neepilisi zegelatin zemveli, iipilisi ze-HPMC azinazithako zeprotheni, ngoko ke umngcipheko wokuchasana nomzimba uyancipha kakhulu. Oku kubaluleke kakhulu kwizigulana ezingadibani neeproteni zezilwanyana, nto leyo eyenza ukuba ichiza likhuseleke ngakumbi ukuba lisetyenziswe kula maqela ezigulana.
(3) Imingeni kunye nethemba le-HPMC yee-capsules ezingenanto kwimveliso yamayeza
Nangona ii-capsules ezingenanto ze-HPMC zineenzuzo ezibalulekileyo kwiinkalo ezininzi, ukusetyenziswa kwazo ngokubanzi kwimveliso yamayeza kusajongene nemingeni ethile. Umzekelo, iindleko eziphezulu ze-HPMC ii-capsules ezingenanto xa kuthelekiswa ne-gelatin capsules yendabuko inokuba ngumqobo kwezinye iimarike ezixabisa ixabiso. Ukongeza, isiqulatho sokufuma se-HPMC ii-capsules ezingenanto ziphantsi, kwaye ukusetyenziswa kwiifom ezithile zedosi eyomileyo kunokufuna ukulungiswa okungaphezulu.
Ngokuqhubela phambili kwetekhnoloji kunye nokwandiswa kwesikali semveliso, iindleko zemveliso yeHPMC iicapsules ezingenanto kulindeleke ukuba zincitshiswe ngakumbi. Kwangaxeshanye, iimfuno ezikhulayo zabathengi zezempilo kunye nokhuseleko lokusingqongileyo ziya kukhuthaza ukusetyenziswa kwee-capsules ezingenanto ze-HPMC kwimarike yehlabathi. Ukongeza, ukwenziwa ngcono kwefomula yee-capsules ezingenanto ze-HPMC kunye nophuhliso lwemathiriyeli emitsha kuya kuphucula ngakumbi ukukhuphisana kwayo kwishishini loxubo-mayeza.
Ii-capsules ezingenanto ze-HPMC zibonise amathemba abanzi kwimveliso yamachiza ngenxa yemvelaphi yezityalo, ukuzinza kweekhemikhali, ukunyibilika okulungileyo kunye ne-bioavailability, ukulungelelaniswa kwesicelo esibanzi kunye ne-allergenicity ephantsi. Ngaphandle kokujongana nemiceli mngeni ethile, ngokuhambela phambili kwetekhnoloji kunye nokukhula kwemfuno yentengiso, ii-capsules ezingenanto ze-HPMC kulindeleke ukuba zithathe indawo ebaluleke ngakumbi kwishishini lezamayeza lexesha elizayo, libonelela iinkampani zamayeza ngokhetho oluninzi kunye namathuba.
Ixesha lokuposa: Sep-03-2024