Hobaneng HEMC e le khetho e betere ho feta HPMC?

Hypromellose (HPMC) le hydroxyethylmethylcellulose (HEMC) ke tse peli tse sebelisoang haholo tse tsoang ho cellulose tse sebelisoang indastering ea meriana, ea lijo le ea litlolo. Le hoja HPMC le HEMC li arolelana lintho tse ngata tse tšoanang, li fapane ka litsela tse ling, li etsa hore e 'ngoe e phahametse e' ngoe bakeng sa likopo tse itseng.

HEMC ke ether e fetotsoeng ea cellulose e fumanoang ka ho arabela methyl cellulose ka ethylene oxide le ethyl chloride, ebe e nkela ethyl bakeng sa hydroxyl. Ka hona, HEMC e na le tekanyo e phahameng ea substitution (DS) ho feta HPMC. DS e bolela palo e tloaelehileng ea lintho tse nkeloang sebaka ka yuniti ea tsoekere, e amang sebopeho le lik'hemik'hale tsa polymer. Ka kakaretso, DS e phahameng e fella ka ho qhibiliha ho betere ho lihlapolli tsa tlhaho, lebelo la ho qhibiliha ka potlako, le tšekamelo e eketsehileng ea ho monya metsi. DS ea HEMC hangata ke 1.7-2.0, athe DS ea HPMC hangata e pakeng tsa 1.2 le 1.5.

Monyetla o ikhethileng oa HEMC ho feta HPMC ke bokhoni ba eona bo botle ba ho boloka metsi, e etsang hore e be e loketseng bakeng sa litlolo tsa sekhomaretsi, lisebelisoa tsa kaho le lihlahisoa tse ling tse hlokang ho bolokoa hantle ha metsi. HEMC e boetse e hanyetsana le tlhaselo ea likokoana-hloko ho feta HPMC 'me e na le nako e telele ea nako. Ho eketseha ha hydrophobicity ea HEMC le ho ba teng ha lihlopha tsa ethyl mokokotlong oa eona ho etsa hore e be emulsifier e babatsehang 'me e ka ntlafatsa botsitso ba nako e telele ea li-emulsions.

Molemo o mong oa ho sebelisa HEMC ke ho lumellana ha eona le lik'hemik'hale tse ling tse ngata, tse tlatsetsang ho feto-fetoha ha eona lits'ebetsong tse fapaneng. Ho phaella moo, HEMC e na le lisebelisoa tse ntle tsa ho etsa lifilimi, tse etsang hore e be molemo bakeng sa tlhahiso ea liphahlo le li-binders tlhahiso ea matlapa, lipilisi le li-granules.

Ka lehlakoreng le leng, HPMC e na le lisebelisoa tse betere tsa ho futhumatsa mocheso, e leng se etsang hore e be khetho e babatsehang bakeng sa lihlahisoa tsa meriana tse fokolang butle tse hlokang li-gel tse thibelang mocheso. HPMC e boetse e na le ho qhibiliha ha metsi ho betere 'me ha e na tšekamelo ea ho etsa li-coagglomerate, e leng li-aggregates tse sa keneng tsa lipolymer ka tharollo.

Qetellong, bobeli ba HEMC le HPMC ke lintho tse tsoang ho cellulose tsa bohlokoa tse fanang ka melemo e fapaneng ho latela ts'ebeliso. HEMC e na le ho boloka metsi hantle, emulsification, le ho lumellana le lik'hemik'hale tse ling, ha HPMC e na le thepa e babatsehang ea thermogelling le ho qhibiliha ha metsi. Ka hona, khetho pakeng tsa HEMC le HPMC e itšetlehile ka kopo e lakatsehang, ts'ebetso ea tlhahiso le litlhoko tsa ho qetela tsa sehlahisoa.