HPMC ke mofuta ofe oa polymer?

HPMC, kapa hydroxypropyl methylcellulose, ke mofuta oa polymer e thehiloeng ho cellulose e sebelisoang haholo indastering ea meriana, ea lijo le ea tlhokomelo ea motho. Cellulose ke polymer ea tlhaho e fumanehang limela 'me ke motsoako o mongata ka ho fetisisa lefatšeng. Ke polymer e melang e entsoeng ka li-glucose monomers tse hokahantsoeng ka libonto tsa β(1→4) tsa glycosidic.

HPMC e hlahisoa ka selulose e fetolang lik'hemik'hale ka lihlopha tsa methyl kapa hydroxypropyl. Liphetoho tsena li ka etsoa ka ho arabela selulose ka li-reagents tse loketseng ka pel'a motsoako oa acid. Boitšoaro pakeng tsa selulose le methyl chloride kapa methyl bromide e hlahisa methylcellulose, ha karabelo pakeng tsa cellulose le propylene oxide e hlahisa hydroxypropyl cellulose. HPMC e hlahisoa ka ho kopanya maikutlo ana a mabeli ho hlahisa lihlopha tsa methyl le hydroxypropyl mokokotlong oa cellulose.

Polymer e hlahisoang e na le sebopeho se rarahaneng se ka fapana ho latela tekanyo ea ho fetola (DS) ea lihlopha tsa methyl le hydroxypropyl. DS e bolela palo e tloaelehileng ea lihlopha tsa hydroxyl tse nkeloang sebaka ka yuniti ea anhydroglucose ka mokokotlong oa cellulose. Ka tloaelo, HPMC e na le DS ea 1.2 ho 2.5 bakeng sa lihlopha tsa methyl le 0.1 ho 0.3 bakeng sa lihlopha tsa hydroxypropyl. Sebopeho sa HPMC se rarahanngoa le ho feta ke taba ea hore lihlopha tsa methyl le hydroxypropyl li ka aroloa ka mokhoa o sa reroang haufi le mokokotlo oa cellulose, e leng se hlahisang polymer e fapaneng e nang le mefuta e mengata ea thepa.

HPMC ke polima e qhibilihang ka metsing e etsang ntho e kang gel ha e nosetsoa. Thepa ea gelation ea HPMC e itšetlehile ka lintlha tse 'maloa, ho kenyelletsa le DS, boima ba molek'hule, le mahloriso a polymer. Ka kakaretso, HPMC e etsa gel e tsitsitseng haholoanyane maemong a holimo le a boleng bo holimo ba DS. Ho feta moo, thepa ea gelation ea HPMC e ka susumetsoa ke pH, matla a ionic, le mocheso oa tharollo.

Thepa e ikhethang ea HPMC e etsa hore e be motsoako oa bohlokoa lits'ebetsong tse ngata. Indastering ea meriana, HPMC e sebelisoa e le ntho e kopanyang, e senyang, le ea ho etsa lifilimi ka matlapa le li-capsules. E ka boela ea sebelisoa ho fetola sekhahla sa ho lokolloa ha lithethefatsi ho tloha foromo ea litekanyetso. Indastering ea lijo, HPMC e sebelisoa e le setenya, se tsitsitseng, le emulsifier. Hangata e sebelisoa lijong tse nang le mafura a tlaase kapa a fokotsehileng-khalori ho etsisa sebōpeho le molomo oa lijo tse nang le mafura a mangata. Indastering ea tlhokomelo ea motho ka mong, HPMC e sebelisoa e le ntho e tenya, e etsang filimi, le emulsifier ho li-shampoo, litlolo le lihlahisoa tse ling.

Qetellong, HPMC ke polymer e thehiloeng ho cellulose e hlahisoang ke cellulose e fetolang lik'hemik'hale ka lihlopha tsa methyl le hydroxypropyl. Polymer e hlahisoang e qhibiliha ka metsing 'me e na le sebopeho se rarahaneng se ka fapana ho itšetlehile ka tekanyo ea ho kenya sebaka le kabo ea lihlopha tsa methyl le hydroxypropyl. HPMC ke polymer e feto-fetohang e nang le lits'ebetso tse ngata indastering ea meriana, ea lijo le ea tlhokomelo ea motho.