Hydroxypropyl methylcellulose (HPMC) ke motsoako o sebetsang ka mokhoa o fapaneng o sebelisoang haholo indastering ea meriana, lijo le litlolo. Sehlahisoa sena sa selulose se tsoa ho selulose ea tlhaho mme se fetotsoe ho fihlela thepa e ikhethileng, e leng se etsang hore e be motsoako oa bohlokoa mefuteng e fapaneng.
1. Selelekela sa Hydroxypropyl Methylcellulose (HPMC)
1.1. Sebopeho sa lik'hemik'hale le thepa
Hydroxypropylmethylcellulose ke semi-synthetic polymer e nkiloeng ho selulose, karolo ea mantlha ea sebopeho sa marako a lisele tsa semela. Sebopeho sa lik'hemik'hale sa HPMC se na le likarolo tsa mokokotlo oa cellulose tse amanang le lihlopha tsa hydroxypropyl le methyl. Tekanyo ea ho nka sebaka sa lihlopha tsena e ama ho solubility, viscosity, le lintho tse ling tsa 'mele tsa polymer.
HPMC hangata e tšoeu kapa e bosoeu ka chebahalo, ha e na monko ebile ha e latsoehe. E qhibiliha ka metsing 'me e etsa litharollo tse hlakileng, tse nang le li-viscous, tse etsang hore e be tsa bohlokoa mefuteng e sa tšoaneng ea likopo.
1.2. Mokhoa oa tlhahiso
Tlhahiso ea hydroxypropyl methylcellulose e kenyelletsa etherification ea selulose ho sebelisa propylene oxide le methyl chloride. Ts'ebetso ena e fetola lihlopha tsa hydroxyl liketane tsa cellulose, e lebisang ho thehoeng ha lihlopha tsa hydroxypropyl le methyl ether. Ho laola tekanyo ea ho kenya sebaka nakong ea ts'ebetso ea tlhahiso ho thusa ho iketsetsa thepa ea HPMC.
2. Lintho tsa 'mele le tsa lik'hemik'hale
2.1. Solubility le viscosity
E 'ngoe ea lintho tse ka sehloohong tsa HPMC ke ho qhibiliha ha eona metsing. Sekhahla sa ho qhibiliha se itšetlehile ka tekanyo ea ho fetola le boima ba molek'hule. Boitšoaro bona ba ho qhibiliha bo etsa hore e tšoanelehe bakeng sa mefuta e fapaneng ea metsoako e hlokang tokollo e laoloang kapa sebopeho sa li-gel.
Viscosity ea tharollo ea HPMC le eona e ka fetoloa, ho tloha ho tlase ho isa ho limaraka tse phahameng tsa viscosity. Thepa ena ke ea bohlokoa bakeng sa ho hokahanya thepa ea rheological ea litlolo tse kang litlolo, li-gel le tharollo ea mahlo.
2.2. Ts'ebetso ea ho etsa lifilimi
HPMC e tsejoa ka bokhoni ba eona ba ho etsa lifilimi, e e etsa motsoako o loketseng oa ho roala matlapa le li-granules. Filimi e hlahisoang e hlakile ebile e tenyetseha, e fana ka lera le sireletsang bakeng sa motsoako o sebetsang oa meriana (API) le ho khothalletsa tokollo e laoloang.
2.3. Ho tsitsa ha mocheso
Hydroxypropyl methylcellulose e na le botsitso bo botle ba mocheso, e e lumellang ho mamella mefuta e mengata ea mocheso o kopanang le eona nakong ea ts'ebetso ea tlhahiso. Thepa ena e thusa ho hlahisa mefuta e tiileng ea litekanyetso, ho kenyelletsa matlapa le li-capsules.
3. Tšebeliso ea hydroxypropyl methylcellulose
3.1. Indasteri ea meriana
HPMC e sebelisoa haholo lefapheng la meriana e le mothusi oa liforomo tsa matlapa mme e na le ts'ebeliso e fapaneng. E sebetsa e le setlamo, se laolang ho arohana le ho lokolloa ha metsoako e sebetsang. Ho phaella moo, thepa ea eona ea ho etsa lifilimi e etsa hore e tšoanelehe bakeng sa ho roala matlapa ho fana ka lera le sireletsang.
Ka molomo mokelikeli formulations, HPMC ka sebelisoa e le suspending agent, thickener, kapa ho fetola viscosity. Tšebeliso ea eona litharollong tsa mahlo e hlokomeleha ka thepa ea eona ea ho khomarela mucoavailability, e leng ho ntlafatsang bioavailability ea mahlo.
3.2. Indasteri ea lijo
Indasteri ea lijo e sebelisa HPMC joalo ka sekontiri se teteaneng le ho hlahisa lihlahisoa tse fapaneng. Bokhoni ba eona ba ho etsa li-gel tse hlakileng le ho laola viscosity bo etsa hore e be ea bohlokoa lits'ebetsong tse kang li-sauces, liaparo le li-confectionery. Hangata HPMC e ratoa ho feta li-thickeners tsa setso ka lebaka la ho feto-fetoha ha maemo le ho haella ha tšusumetso ho boleng ba kutlo ba lihlahisoa tsa lijo.
3.3. Litlolo le lihlahisoa tsa tlhokomelo ea botho
Ka litlolo tsa litlolo, HPMC e sebelisoa bakeng sa ho tiea, ho tsitsisa le thepa ea ho etsa lifilimi. Hangata e fumanoa litlolong, litlolo, le lihlahisoa tsa tlhokomelo ea moriri. Bokhoni ba polymer ba ho ntlafatsa sebopeho le botsitso ba litlolo bo kenya letsoho ts'ebelisong ea eona e atileng indastering ea litlolo.
3.4. Indasteri ea kaho
HPMC e sebelisoa indastering ea kaho e le setsi sa ho boloka metsi bakeng sa seretse se thehiloeng ho samente le lisebelisoa tse thehiloeng ho gypsum. Mosebetsi oa eona ke ho matlafatsa ts'ebetso, ho thibela mapetsong, le ho ntlafatsa ho khomarela.
4. Litaelo tsa taolo le boemo ba polokeho
4.1. Boemo ba taolo
Hydroxypropyl methylcellulose ka kakaretso e amoheloa e le e bolokehileng (GRAS) ke mekhatlo ea taolo e kang US Food and Drug Administration (FDA) le European Food Safety Authority (EFSA). E kopana le maemo a fapaneng a pharmacopoeial mme e thathamisitsoe ho monographs ea eona e fapaneng.
4.2. Tshireletso kakaretso
Joalo ka karolo e sebelisoang haholo, HPMC e na le boemo bo botle ba polokeho. Leha ho le joalo, batho ba nang le allergy e tsebahalang ea lintho tse tsoang ho cellulose ba lokela ho ba hlokolosi. Khokahano ea HPMC ka foromo e laoloa ka thata ho netefatsa polokeho, e leng bohlokoa ho batho. Baetsi ba latela litataiso tse hlophisitsoeng.
5. Qetello le litebello tsa nako e tlang
Hydroxypropyl methylcellulose e hlahile e le mothusi ea nang le mekhoa e mengata ea ho sebelisa mekhoa e mengata indastering ea meriana, ea lijo, ea litlolo le ea kaho. Motsoako oa eona o ikhethang oa solubility, viscosity control le thepa ea ho etsa filimi e etsa hore e be motsoako oa bohlokoa mekhoeng e mengata.
Patlisiso e tsoelang pele le nts'etsopele lefapheng la mahlale a polymer e ka lebisa tsoelo-peleng ea ts'ebetso ea HPMC ho fihlela litlhoko tse ikhethang tsa indasteri. Ha tlhoko ea litlolo tse laoloang le nts'etsopele ea lihlahisoa tse ncha e ntse e hola, hydroxypropyl methylcellulose e kanna ea boloka karolo ea eona e hlahelletseng joalo ka mothusi ea fapaneng.
Nako ea poso: Jan-15-2024