K'hothone e hloekisitsoeng-ho bula-alkalization-etherification-neutralization-karohano-ho hlatsoa-ho arohana-ho omisa-ho senya-ho phuthela-ho qeta ho bula sehlahisoa sa HPMC: K'hothone e hloekisitsoeng e buloa ho tlosa tšepe ebe e pshatleha. K'hothone e hloekisitsoeng e hloekisitsoeng e entsoe ka phofo, e nang le boholo ba likaroloana tsa 80 mesh le phetisetso ea 100%. Ho seng joalo, ho bonolo ho kopanya hammoho nakong ea ts'ebetso le ho fokotsa katleho ea etherification.
Alkalization: Eketsa k'hothone e hloekisitsoeng e entsoeng ka phofo ka mor'a hore k'hothone e butsoe ho motsoako o sa sebetseng, 'me ue sebelise ka alkali le metsi a bonolo ho ruruha lesela la k'hothone e hloekisitsoeng ho thusa ho kenella ha limolek'hule tsa etherification le ho ntlafatsa ho tšoana ha karabelo ea etherification. Alkali e sebelisetsoang alkalization ke tšepe hydroxide kapa alkali ea tlhaho. Palo ea alkali e ekelitsoeng (ka boima, e tšoanang ka tlase) ke makhetlo a 0.1-0.6 a k'hothone e hloekisitsoeng, palo ea metsi a bonolo a kenyelletsoeng ke makhetlo a 0.3-1.0 a k'hothone e hloekisitsoeng; solvent inert ke motsoako oa joala le hydrocarbon, 'me palo ea solvent inert e ekelitsoeng ke makhetlo a 0.3-1.0 a k'hothone e hloekisitsoeng. 7 -15 linako tse ling: The solvent inert e ka boela ea e-ba joala bo nang le liathomo tsa carbon tse 3-5 (tse kang joala, propanol), acetone. E ka boela ea e-ba li-hydrocarbon tsa aliphatic le li-hydrocarbon tse nkhang hamonate; mocheso o lokela ho laoloa ka hare ho 0-35 ° C nakong ea alkalization; nako ea alkalization ke hoo e ka bang 1hr. Tokiso ea mocheso le nako e ka khethoa ho latela litlhoko tsa thepa le sehlahisoa.
Etherification: Ka mor'a phekolo ea alkalization, tlas'a maemo a vacuum, moemeli oa etherification o eketsoa bakeng sa etherification, 'me moemeli oa etherification ke propylene oxide. E le ho fokotsa ts'ebeliso ea etherification agent, nakong ea ts'ebetso ea etherification, moemeli oa etherification o eketsoa ka makhetlo a mabeli, palo ea kenyelletso ea pele ke makhetlo a 1-3.5 ea k'hothone e hloekisitsoeng, 'me kakaretso ea likarolo tse peli ke 1.5. -Makhetlo a 4 a k'hothone e hloekisitsoeng. linako. Ka mor'a ho eketsa moemeli oa etherifying ka lekhetlo la pele, tsosa ka ≤30 ° C bakeng sa 45min-90min, ebe o phahamisa mocheso ho 50-100 ° C bakeng sa etherification bakeng sa 1-5h, ebe o pholile ho fihlela ≤30 ° C, lekhetlo la bobeli. ho eketsa etherification susumetsang maikutlo, susumetsang maikutlo nako ke 30-120min, 'me joale halefile ho? ? ? Etsa etherification, nako ke 1-4h, ka nako ena, k'hothone e hloekisitsoeng e sebetsana ka botlalo le moemeli oa etherification ho hlahisa hYDROXYPROPYL METHYLCELLULOSE HPMC.
Ho pshatla le ho paka: ho pshatla le ho sefa sehlahisoa se omisitsoeng sa tlhahiso ea hona joale, boholo ba karoloana ea sehlahisoa sa HPMC sa tlhahiso ea hona joale ka mor'a ho silakanya le ho sefa ke 40 mesh mme phetisetso ke 10096, kapa ho latela litlhoko tsa mosebedisi. Ebe u paka HPMC.
Nako ea poso: Nov-24-2022