Low-substituted hydroxypropylmethylcellulose (L-HPMC) ke polymer e feto-fetohang, e nang le mefuta e mengata e sebelisoang liindastering tse fapaneng, ho kenyeletsoa meriana, lijo, kaho le litlolo. Motsoako ona o tsoa ho cellulose, polymer ea tlhaho e fumanehang maboteng a lisele tsa semela. Ho utloisisa hydroxypropyl methylcellulose e nkeloang sebaka e tlase, motho o tlameha ho senya lebitso la eona le ho hlahloba thepa ea eona, ts'ebeliso, motsoako le phello liindasteri tse fapaneng.
1. Kutloisiso ea mabitso:
Hydroxypropyl methylcellulose (HPMC):
Cellulose ke lik'habohaedreite tse rarahaneng tse entsoeng ka likarolo tsa tsoekere 'me ke karolo ea mantlha ea marako a lisele tsa semela.
Hydroxypropyl methylcellulose ke mofuta o fetotsoeng oa selulose o sebelisitsoeng ka lik'hemik'hale ho hlahisa lihlopha tsa hydroxypropyl le methyl. Phetoho ena e ntlafatsa ho qhibiliha ha eona le lintho tse ling tse lakatsehang.
Phapang e tlase:
E bolela boemo bo batlang bo le tlase ba ho nka sebaka ha ho bapisoa le tse ling tse tsoang ho selulose, joalo ka tse nkiloeng sebakeng se phahameng joalo ka hydroxyethyl cellulose (HEC).
2. Tshebetso:
Sollubility:
L-HPMC e qhibiliha haholo metsing ho feta selulose.
Viscosity:
The viscosity ea L-HPMC tharollo e ka laoloa ka ho fetola tekanyo ea ho fetola, ho etsa hore e tšoanelehe bakeng sa mefuta e mengata ea likopo.
Moetso oa lifilimi:
L-HPMC e ka etsa lifilimi tse tšesaane, ea e etsa hore e be molemo mefuteng e fapaneng ea ho roala.
Thermal stability:
Polymer ka kakaretso e bonts'a botsitso bo botle ba mocheso, e tlatsetsang ho feto-fetoha ha eona lits'ebetsong tse fapaneng.
3. Tšimoloho:
Etherification:
Sehlahisoa se kenyelletsa etherification ea cellulose ka propylene oxide ho hlahisa lihlopha tsa hydroxypropyl.
Methylation e latelang e nang le methyl chloride e eketsa lihlopha tsa methyl mokokotlong oa cellulose.
Tekanyo ea ho kenya sebaka e ka laoloa nakong ea ho kopanya ho fumana thepa e lakatsehang.
4. Kopo:
A. Indasteri ea meriana:
Li-binders le li-disintegrants:
E sebelisoa e le setlamo mefuteng ea letlapa ho kopanya metsoako.
E sebetsa joalo ka disintegrant ho khothaletsa ho senyeha ha matlapa a tsamaiso ea tšilo ea lijo.
Tokollo e tsitsitseng:
L-HPMC e sebelisoa mefuteng e laoloang ea tokollo, e lumellang moriana hore o lokolloe butle-butle ha nako e ntse e ea.
Litokisetso tsa sehlooho:
E fumanoa ka litlolo, li-gel le litlolo, e fana ka viscosity le ho ntlafatsa ho ata ha liforomo.
B. Indasteri ea lijo:
Thickener:
E eketsa viscosity ea lijo 'me e ntlafatsa sebopeho le molomo.
stabilizer:
E matlafatsa botsitso ba emulsions le ho emisoa.
Moetso oa lifilimi:
Lifilimi tse jeoang bakeng sa ho paka lijo.
C. Indasteri ea kaho:
Seretse le samente:
E sebelisoa e le sesebelisoa sa ho boloka metsi linthong tse entsoeng ka samente.
Ntlafatsa mokhoa oa ho sebetsa le ho khomarela libopeho tsa seretse.
D. Litlolo:
Lihlahisoa tsa tlhokomelo ea motho ka mong:
E fumanoa ka litlolo, litlolo le li-shampoo ho thusa ho ntlafatsa sebopeho le botsitso.
E sebelisoa e le moemeli oa ho etsa lifilimi ho litlolo.
5. Tlhokomelo:
E amohetsoe ke FDA:
L-HPMC ka kakaretso e amoheloa e le e bolokehileng (GRAS) ke Tsamaiso ea Lijo le Lithethefatsi ea US (FDA).
Ho ikamahanya le maemo a taolo ho bohlokoa bakeng sa tšebeliso ea eona litlhare le lijong.
6. Mathata le litebello tsa kamoso:
Biodegradability:
Le hoja li-polymers tse thehiloeng ho cellulose hangata li nkoa li ka senyeha, tekanyo ea biodegradation ea li-derivative derivatives tsa cellulose e hloka lipatlisiso tse eketsehileng.
Moshoelella:
Tlhokomelo e tsitsitseng ea thepa e tala le mekhoa ea tlhahiso e baballang tikoloho ke libaka tse ntseng li tsoela pele ho tsepamisa maikutlo.
7. Qetello:
Hydroxypropyl methylcellulose e nkeloang sebaka e tlase e bonts'a bohlale ba ho fetola lik'hemik'hale ho sebelisa hampe thepa ea li-polymer tsa tlhaho. Lisebelisoa tsa eona tse fapaneng liindastering tse fapaneng li totobatsa bohlokoa ba eona tlhahisong ea sejoale-joale. Ha tsoelo-pele ea theknoloji le ts'ebetso e ntse e tsoela pele, lipatlisiso tse tsoelang pele le ntlafatso ea L-HPMC le metsoako e ts'oanang li ka theha bokamoso ba mahlale a thepa le mekhoa ea indasteri.
Nako ea poso: Dec-26-2023