Hydroxypropylcellulose (HPC) ke motsoako oa maiketsetso oa cellulose, polima ea tlhaho e fumanehang maboteng a lisele tsa semela. Tlhahiso ea hydroxypropylcellulose e kenyelletsa phetoho ea lik'hemik'hale ea selulose ka letoto la karabelo. Phetoho ena e fana ka thepa e ikhethang ea selulose e e etsang hore e be molemo mefuteng e fapaneng ea lits'ebetso tsa indasteri le tsa meriana.
Sebopeho sa hydroxypropylcellulose:
Hydroxypropylcellulose ke motsoako oa hydroxyalkyl oa selulose moo sehlopha sa hydroxypropyl se hokeloang mokokotlong oa cellulose. Mokokotlo oa cellulose ka boeona ke letoto la li-unit tsa tsoekere tse hokahantsoeng ke β-1,4-glycosidic bond. Lihlopha tsa Hydroxypropyl li hlahisoa ka ho arabela selulose ka propylene oxide ka pel'a motsoako oa alkaline.
Tekanyo ea ho fetola (DS) ke parameter ea bohlokoa e hlalosang sebopeho sa hydroxypropylcellulose. E emela palo e tloaelehileng ea lihlopha tsa hydroxypropyl ka yuniti ea tsoekere ka ketane ea cellulose. DS e ka laoloa nakong ea ts'ebetso ea ho kopanya, e lumellang tlhahiso ea hydroxypropylcellulose ka likarolo tse fapaneng tsa ho fetola ho finyella litlhoko tse khethehileng tsa kopo.
Motsoako oa hydroxypropylcellulose:
Motsoako oa hydroxypropylcellulose o kenyelletsa karabelo lipakeng tsa cellulose le propylene oxide. Hangata karabelo ena e etsoa ka pel'a lintho tse ka sehloohong tse thusang tse kang sodium hydroxide. Li-catalyst tsa alkaline li khothalletsa ho buleha ha selikalikoe sa epoxy ka propylene oxide, e leng se etsang hore ho eketsoe lihlopha tsa hydroxypropyl ho ketane ea cellulose.
Karabelo e atisa ho etsoa ka solvent 'me mocheso le nako ea ho itšoara li laoloa ka hloko ho finyella tekanyo e lakatsehang ea ho fetola. Ka mor'a karabelo, sehlahisoa se hloekisoa ka mekhoa e kang ho hlatsoa le ho sefa ho tlosa li-reagents tse sa sebetseng kapa lihlahisoa.
Litšobotsi tsa Hydroxypropyl Cellulose:
Solubility: Hydroxypropylcellulose e qhibiliha ka har'a mefuta e fapaneng ea solvents, ho kenyeletsoa metsi, ethanol, le metsoako e mengata ea tlhaho. Thepa ena ea solubility e etsa hore e tšoanelehe bakeng sa lits'ebetso tse fapaneng.
Viscosity: Ho kenyelletsa lihlopha tsa hydroxypropyl ho selulose ho eketsa ho qhibiliha le ho fetola thepa ea viscosity ea polymer. Sena se etsa hore hydroxypropylcellulose e be ea bohlokoa mekhoeng ea meriana, hangata e le ntho e teteaneng kapa ea ho etsa li-gellling.
Tlhahiso ea Lifilimi: Hydroxypropylcellulose e ka etsa lifilimi tse feto-fetohang le tse hlakileng, e leng se etsang hore e tšoanelehe bakeng sa ho roala, lifilimi le joalo ka setlamo sa li-tablet formulations.
Thermal Stability: Hydroxypropylcellulose e na le botsitso bo botle ba mocheso, e lumellang hore e sebelisoe mefuteng e sa tšoaneng ea mekhoa ea indasteri ntle le ho senyeha ho hoholo.
Ho lumellana: E lumellana le mefuta e meng ea li-polymers le li-excipients, e ntlafatsang molemo oa eona ho lihlahisoa tsa meriana le tsa litlolo.
Lisebelisoa tsa Hydroxypropyl Cellulose:
Meriana ea Meriana: Hydroxypropylcellulose e sebelisoa haholo indastering ea meriana e le tlamahano ea li-tablet formulations, mofetoleli oa viscosity ka mefuta ea litekanyetso tsa mokelikeli, le moemeli oa ho etsa filimi ka liphahlo bakeng sa mefuta ea litekanyetso tsa molomo.
Lihlahisoa tsa Tlhokomelo ea Botho: Ka litlolo le lihlahisoa tsa tlhokomelo ea botho, hydroxypropylcellulose e sebelisoa e le motenya, stabilizer le moemeli oa ho etsa lifilimi lihlahisoa tse kang litlolo, litlolo le mekhoa ea tlhokomelo ea moriri.
Likopo tsa Liindasteri: Ka lebaka la thepa ea eona ea ho etsa lifilimi le ho khomarela, hydroxypropylcellulose e ka sebelisoa mefuteng e sa tšoaneng ea indasteri, ho kenyelletsa le ho roala, li-adhesives le e le tlamahano ha ho etsoa lihlooho tse bōpiloeng.
Indasteri ea Lijo: Ka indastering ea lijo, hydroxypropylcellulose e ka sebelisoa e le motenya le botsitso mefuteng e itseng ea lijo.
Indasteri ea masela: Hydroxypropyl cellulose e ka sebelisoa indastering ea masela ka thepa ea eona ea ho etsa lifilimi le sekhomaretsi ho thusa ho phethela masela.
Hydroxypropyl cellulose ke motsoako oa selulose o fetotsoeng o sebelisoang haholo meriana, lihlahisoa tsa tlhokomelo ea botho, le lits'ebetso tse fapaneng tsa indasteri ka lebaka la ho qhibiliha ha eona, thepa ea ho fetola viscosity, bokhoni ba ho etsa lifilimi, le ho lumellana le lisebelisoa tse ling. Ho feto-fetoha ha eona le ho laoloa ha eona ho etsa hore e be polymer ea bohlokoa lits'ebetsong tse fapaneng.
Nako ea poso: Dec-26-2023