Hydroxypropyl methyl cellulose ke eng?

Hydroxypropyl methylcellulose(HPMC) ke polymer ea maiketsetso e sebelisoang haholo liindastering tse fapaneng, ho kenyeletsoa meriana, lijo, litlolo le kaho. Ke mofuta oa cellulose ether e hlahisoang ke phetoho ea lik'hemik'hale ea cellulose ea tlhaho, e leng lik'habohaedreite tse rarahaneng tse fumanoang limela. HPMC ke motsoako o qhibilihang ka metsing, o sa nkheng, o sa latsoeheng o nang le lintho tse ngata tse etsang hore e sebelisoe mefuteng e mengata ea ts'ebeliso.

HPMC e entsoe ka likarolo tse peli tsa mantlha: methyl cellulose (MC) le hydroxypropyl cellulose (HPC). MC ke motsoako oa selulose o fumanoang ka ho arabela selulose ka sodium hydroxide le methyl chloride. Ts'ebetso ena e fella ka ho eketsoa ha lihlopha tsa methyl mokokotlong oa cellulose, e leng ho ntlafatsang ho qhibiliha ha eona metsing. HPC, ka lehlakoreng le leng, e tsoa ho selulose e fumanoang ka ho e arabela ka propylene oxide. Ts'ebetso ena e fella ka ho eketsoa ha lihlopha tsa hydroxypropyl mokokotlong oa cellulose, e leng ho ntlafatsang ho qhibiliha ha eona metsing.

Motsoako oa likarolo tsena tse peli ho HPMC e fana ka thepa e ikhethang joalo ka ho eketseha ha viscosity, ho boloka metsi ho ntlafetseng, le ho khomarela ho ntlafatsa. E boetse e na le bokhoni ba ho etsa li-gel ha e kopantsoe le metsi, e leng se etsang hore e be molemo e le ntho e teteaneng liindastering tse ngata.

Lisebelisoa tsa Meriana tsa HPMC

E 'ngoe ea litšebeliso tsa mantlha tsa HPMC ke indastering ea meriana, moo e sebelisoang e le thuso ho etsoa ha lihlahisoa tse fapaneng tsa lithethefatsi. Excipient ke ntho e eketsoang sehlahiswang sa moriana ho nolofatsa ho etswa, tsamaiso, kapa ho monya ha sona. HPMC e atisa ho sebelisoa e le setlamo, disintegrant, le thickening agent ha ho etsoa matlapa, capsules, le mefuta e meng e tiileng ea litekanyetso.

Meetsong ea matlapa, HPMC e sebelisoa e le setlamo ho tšoara motsoako o sebetsang le lisebelisoa tse ling hammoho. E boetse e sebetsa joalo ka disintegrant, e thusang letlapa hore le arohane ha le kopana le metsi kapa maro a mang a 'mele. HPMC e na le thuso ka ho khetheha e le sehlaseli matlapeng a reretsoeng ho metsoa kaofela, kaha e lumella letlapa hore le arohane ka potlako le ho lokolla motsoako o sebetsang.

HPMC e boetse e sebelisoa e le moemeli oa thickening ka mefuta ea litekanyetso tsa mokelikeli tse kang suspensions, emulsions, le li-gel. E ntlafatsa viscosity le sebopeho sa libopeho tsena, tse ka ntlafatsang botsitso le boiketlo ba tsamaiso. Ho feta moo, HPMC e ka sebelisoa e le moemeli oa tokollo e tsitsitseng, e lumellang moriana hore o lokolloe butle-butle ka nako e telele.

Lisebelisoa tsa Lijo tsa HPMC

Indastering ea lijo, HPMC e sebelisoa e le ntho e matlafatsang, emulsifier le stabilizer. Hangata e sebelisoa ka li-sauces, li-dressings le lihlahisoa tse ling tsa lijo tse metsi ho ntlafatsa sebopeho le botsitso ba tsona. HPMC e ka boela ea sebelisoa e le phetisetso ea mafura lihlahisoa tsa lijo tse nang le mafura a tlaase, kaha e ka etsisa sebōpeho le molomo oa mafura ntle le ho eketsa lik'hilojule tse eketsehileng.

Lisebelisoa tsa Cosmetic tsa HPMC

HPMC e boetse e sebelisoa indastering ea litlolo e le sekontiri, emulsifier, le binder. Hangata e sebelisoa litlolong, litlolo, le lihlahisoa tse ling tsa litlolo ho ntlafatsa sebopeho sa tsona le botsitso. HPMC e ka boela ea sebelisoa e le moemeli oa ho etsa lifilimi, e ka ntlafatsang ho khomarela le ho hanyetsa metsi ka lihlahisoa tsa litlolo.

Likopo tsa Kaho tsa HPMC

Indastering ea kaho, HPMC e sebelisoa e le sekontiri se teteaneng le se bolokang metsi mefuteng ea samente le ea seretse. E ka ntlafatsa ts'ebetso le ts'ebetso ea libopeho tsena, tse ka ntlafatsang ts'ebetso ea tsona le ho tšoarella. HPMC e ka boela ea sebelisoa e le colloid e sireletsang, e ka thibelang ho bokellana ha likaroloana tsa samente le ho ntlafatsa dispersibility ea bona.

Polokeho le Taolo

HPMC ka kakaretso e nkuoa e bolokehile hore e ka sebelisoa lijong, meriana le lihlahisoa tsa litlolo. E 'nile ea ithutoa haholo bakeng sa polokeho ea eona le chefo,' me e khetholloa e le ntho e seng chefo, e seng carcinogenic, le e seng ea mutagenic.

United States, HPMC e laoloa ke Tsamaiso ea Lijo le Lithethefatsi (FDA) e le tlatsetso ea lijo, le ke United States Pharmacopeia (USP) joalo ka mothusi oa meriana. E boetse e laoloa ke mekhatlo e meng ea taolo linaheng tse fapaneng lefatšeng ka bophara.

Ho sa tsotelehe polokeho ea eona, HPMC e ka baka matšoao a bobebe a mala a kang ho ruruha, flatulence, le letšollo ho batho ba bang. Matšoao ana hangata ha a bobebe ebile a ikemela, 'me a ka qojoa ka ho sebelisa HPMC ka mokhoa o itekanetseng.

Qetellong, hydroxypropyl methylcellulose (HPMC) ke polymer ea maiketsetso e feto-fetohang le e sebelisoang haholo e nang le lits'ebetso tse ngata liindastering tse fapaneng. Litšobotsi tsa eona tse ikhethang, tse kang ho eketseha ha viscosity, ho boloka metsi ho ntlafatsa, le ho khomarela ho matlafalitsoeng, li etsa hore e be thuso e le ntho e matlafatsang, emulsifier, stabilizer le binder lihlahisoa tsa meriana, lijo, litlolo le kaho. HPMC ka kakaretso e nkuwa e bolokehile mme e laolwa ke ditheo tse fapaneng tsa taolo lefatsheng ka bophara.