Hydroxypropyl Methylcellulose (HPMC) ke polima ea bohlokoa e qhibilihang ka metsing e sebelisoang haholo ho tsa meriana, lijo, liphahlo, thepa ea mohaho le masimo a mang. The viscosity ea tharollo ea HPMC ke ntlha ea bohlokoa e amang ts'ebetso le ts'ebeliso ea eona, 'me mocheso o na le tšusumetso e kholo ho viscosity ea tharollo ea metsi a HPMC.
1. Litšobotsi tsa viscosity tsa tharollo ea HPMC
HPMC ke thepa ea polymer e nang le thepa ea ho qhibiliha e ka fetoloang ka mocheso. Ha HPMC e qhibiliha ka metsing, tharollo ea metsi e entsoeng ka metsi e bonts'a litšobotsi tsa mokelikeli o seng oa Newtonian, ke hore, viscosity ea tharollo e fetoha ka liphetoho tsa sekhahla sa ho kuta. Ka mocheso o tloaelehileng, tharollo ea HPMC hangata e sebetsa joalo ka maro a pseudoplastic, ke hore, a na le viscosity e phahameng ka litekanyetso tse tlase tsa ho kuta, 'me viscosity e fokotseha ha sekhahla sa ho kuta se ntse se eketseha.
2. Phello ea mocheso ho viscosity ea tharollo ea HPMC
Liphetoho tsa mocheso li na le mekhoa e 'meli e meholo ea tšusumetso ho viscosity ea tharollo ea metsi a HPMC: ho eketseha ha mocheso oa liketane tsa limolek'hule le liphetoho litšebelisanong tsa tharollo.
(1) Ho sisinyeha ha mocheso oa liketane tsa limolek'hule hoa eketseha
Ha mocheso o ntse o eketseha, ho sisinyeha ha mocheso oa ketane ea limolek'hule ea HPMC hoa eketseha, e leng se etsang hore maqhama a hydrogen le matla a van der Waals pakeng tsa limolek'hule a fokotsehe le ho eketseha ha metsi a tharollo. Viscosity ea tharollo e fokotseha ka lebaka la ho fokotseha ho fokolang le ho hokahanya ha 'mele pakeng tsa liketane tsa limolek'hule. Ka hona, litharollo tsa metsi tsa HPMC li bonts'a viscosity e tlase ho mocheso o phahameng.
(2) Liphetoho tšebelisanong ea tharollo
Liphetoho tsa mocheso li ka ama ho qhibiliha ha limolek'hule tsa HPMC metsing. HPMC ke polymer e nang le thepa ea thermogelling, 'me ho qhibiliha ha eona metsing ho fetoha haholo ka mocheso. Ka mocheso o tlase, lihlopha tsa hydrophilic ho ketane ea limolek'hule ea HPMC li theha maqhama a tsitsitseng a hydrogen le limolek'hule tsa metsi, ka hona li boloka ho qhibiliha ho hotle le viscosity e phahameng. Leha ho le joalo, ha mocheso o nyolohela boemong bo itseng, ho sebelisana ha hydrophobic pakeng tsa liketane tsa limolek'hule tsa HPMC ho ntlafatsoa, e lebisang ho thehoeng ha sebopeho sa marang-rang a mararo kapa gelation ka tharollo, ho etsa hore viscosity ea tharollo e eketsehe ka tšohanyetso tlas'a maemo a itseng. Ketsahalo ena e bitsoa Ke "thermal gel" phenomenon.
3. Teko ea teko ea mocheso ho HPMC tharollo ea viscosity
Liphuputso tsa liteko li bontšitse hore ka har'a mefuta e tloaelehileng ea mocheso (mohlala, 20 ° C ho ea ho 40 ° C), viscosity ea HPMC ea tharollo ea metsi e fokotseha butle-butle ka mocheso o ntseng o eketseha. Lebaka ke hobane mocheso o phahameng o eketsa matla a kinetic a liketane tsa limolek'hule le ho fokotsa ho sebelisana ha limolek'hule, kahoo ho fokotsa ho ferekana ka hare ho tharollo. Leha ho le joalo, ha mocheso o ntse o eketseha ho ea sebakeng sa mocheso oa gel ea HPMC (hangata pakeng tsa 60 ° C le 90 ° C, ho itšetlehile ka tekanyo ea ho kenya sebaka le boima ba molek'hule ea HPMC), viscosity ea tharollo e eketseha ka tšohanyetso. Ketsahalo ea ketsahalo ena e amana le ho kopanngoa le ho kopanya ha liketane tsa limolek'hule tsa HPMC.
4. Kamano pakeng tsa mocheso le HPMC meralo parameters
Tharollo ea viscosity ea HPMC ha e amehe feela ke mocheso, empa hape e amana haufi-ufi le sebopeho sa eona sa limolek'hule. Mohlala, tekanyo ea ho kenya sebaka (ke hore, likahare tsa hydroxypropyl le methyl substituents) le boima ba limolek'hule tsa HPMC li na le phello e kholo boitšoarong ba eona ba gel ea mocheso. HPMC e nang le boemo bo phahameng ba ho fetola e boloka viscosity e tlaase sebakeng se pharaletseng sa mocheso ka lebaka la lihlopha tsa eona tsa hydrophilic, ha HPMC e nang le tekanyo e tlaase ea ho fetola ho ka etsahala hore e thehe li-gel tsa mocheso. Ho feta moo, litharollo tsa HPMC tse nang le boima bo phahameng ba limolek'hule li ka 'na tsa eketseha ka viscosity ka mocheso o phahameng.
5. Maikutlo a Liindasteri le a Sebetsang a Kopo
Lits'ebetsong tse sebetsang, mefuta e nepahetseng ea HPMC e hloka ho khethoa ho latela maemo a itseng a mocheso. Ka mohlala, libakeng tse nang le mocheso o phahameng, HPMC e nang le khanyetso e phahameng ea mocheso e hloka ho khethoa ho qoba gelation ea mocheso. Tlas'a maemo a tlase a mocheso, ho tsitsa le ho tsitsa ha viscosity ea HPMC ho hloka ho nahanoa.
Phello ea mocheso ho viscosity ea tharollo ea metsi ea HPMC e na le bohlokoa ba bohlokoa bo sebetsang. Lefapheng la meriana, HPMC e atisa ho sebelisoa e le lisebelisoa tse sa khaotseng bakeng sa litokisetso tsa meriana, 'me litšobotsi tsa eona tsa viscosity li ama ka ho toba sekhahla sa ho lokolloa ha lithethefatsi. Indastering ea lijo, HPMC e sebelisetsoa ho ntlafatsa sebopeho le botsitso ba lihlahisoa, 'me ho itšetleha ka mocheso oa viscosity ea eona ea tharollo ho hloka ho fetoloa ho latela mocheso oa ho sebetsa. Linthong tsa kaho, HPMC e sebelisoa e le setsi sa ho thibela metsi le ho boloka metsi, 'me litšobotsi tsa eona tsa viscosity li ama ts'ebetso ea kaho le matla a thepa.
Phello ea mocheso ho viscosity ea tharollo ea metsi a HPMC ke ts'ebetso e rarahaneng e kenyelletsang ho sisinyeha ha mocheso oa ketane ea molek'hule, ho sebelisana ha tharollo, le thepa ea sebopeho sa polymer. Ka kakaretso, viscosity ea litharollo tsa metsi tsa HPMC hangata e fokotseha ka mocheso o ntseng o eketseha, empa maemong a itseng a mocheso, ho ka etsahala hore ho be le mocheso o chesang. Ho utloisisa tšobotsi ena ho na le bohlokoa ba tataiso bakeng sa ts'ebeliso e sebetsang le ntlafatso ea ts'ebetso ea HPMC.
Nako ea poso: Jul-10-2024