Hypromellose, e tsejoang hape e le hydroxypropyl methylcellulose (HPMC), ke polymer ea maiketsetso e nkiloeng ho selulose. E sebelisoa hangata liindastering tse fapaneng, ho kenyelletsa le tsa meriana, litlolo, le lihlahisoa tsa lijo. Litlhare, hypromellose e na le lisebelisoa tse 'maloa ka lebaka la thepa ea eona e ikhethang.
1. Kenyelletso ea Hypromellose:
Hypromellose ke polymer ea hydrophilic e etsang tharollo e hlakileng, ea viscous ha e qhibiliha ka metsing. Hangata e sebelisoa e le motsoako o sa sebetseng litlhahlobong tsa meriana ho ntlafatsa litšobotsi tsa sehlahisoa tse kang viscosity, botsitso le bioavailability. Hypromellose e sebelisoa haholo mefuteng ea litekanyetso tse tiileng tsa molomo, litokisetso tsa mahlo le li-topical formulations.
2. Lisebelisoa tsa Meriana:
a. Liforomo tsa Oral Solid Dosage:
Meriana ea molomo, hypromellose e sebeletsa merero e fapaneng:
Binder: E thusa ho kopanya metsoako e sebetsang ea meriana (APIs) hammoho ho etsa matlapa kapa li-capsules.
Disintegrant: Hypromellose e thusa ho arohana ha matlapa kapa li-capsules ka har'a pampitšana ea mala, ho khothalletsa ho lokolloa ha lithethefatsi le ho monya.
Film Former: E sebelisoa ho etsa filimi e tšesaane, e sireletsang matlapeng bakeng sa litlhophiso tse laoloang kapa ho pata litakatso tse sa thabiseng.
b. Litokisetso tsa Ophthalmic:
Marotholi a mahlo le litlolo, hypromellose e sebetsa joalo ka:
Viscosity Modifier: E eketsa viscosity ea marotholi a mahlo, e fana ka nako e telele ea ho kopana le bokaholimo ba mahlo le ho ntlafatsa phano ea lithethefatsi.
Lubricant: Hypromellose e tlotsa bokaholimo ba leihlo, e imolla ho omella le ho se thabise ho amanang le maemo a kang lefu la mahlo a omileng.
c. Meetso ea Lihlooho:
Lihlahisoa tsa lihlooho tse kang litlolo, li-gel le litlolo, hypromellose e sebetsa joalo ka:
Gelling Agent: E thusa ho theha sebopeho se kang sa gel, ho ntlafatsa ho ata le ho khomarela sehlahisoa letlalong.
Moisturizer: Hypromellose e boloka mongobo, e nosetsa letlalo le ho thibela tahlehelo ea metsi.
3. Mokhoa oa Ts'ebetso:
Mokhoa oa ts'ebetso oa Hypromellose o ipapisitse le ts'ebeliso ea ona:
Oral Administration: Ha e kenngoa, hypromellose e ruruha ha e kopana le metsi ka har'a pampiri ea mala, e khothalletsang ho arohana le ho qhibiliha ha foromo ea litekanyetso. Sena se lumella tokollo e laoloang le ho monya meriana.
Tšebeliso ea Ophthalmic: Ho marotholi a mahlo, hypromellose e eketsa ponahalo ea tharollo, e lelefatsa nako ea ho kopana le mahlo le ho matlafatsa ho monya ha lithethefatsi. E boetse e fana ka lubrication ho imolla ho omella le ho teneha.
Tšebeliso ea Lihlooho: Joaloka moemeli oa gelling, hypromellose e etsa lesela le sireletsang letlalong, le thibela ho lahleheloa ke mongobo le ho nolofatsa ho kenngoa ha metsoako e sebetsang.
4. Boemo ba Polokeho:
Hypromellose ka kakaretso e nkuoa e bolokehile hore e ka sebelisoa litlhare, litlolo le lihlahisoa tsa lijo. Ha e na chefo, ha e tenehe ebile ha e na allergenic. Leha ho le joalo, batho ba nang le hypersensitivity ho lintho tse tsoang ho cellulose ba lokela ho qoba lihlahisoa tse nang le hypromellose. Ho feta moo, marotholi a mahlo a nang le hypromellose a ka baka phokotso ea nakoana ea pono hang ka mor'a tsamaiso, eo hangata e rarollang kapele.
5. Litla-morao tse ka bang teng:
Leha hypromellose e mamelloa hantle ke batho ba bangata, litla-morao tse ling tse sa tloaelehang li ka hlaha, ho kenyelletsa:
Maemo a Allergic: Ho batho ba nang le kutloelo-bohloko, maikutlo a hypersensitivity a kang ho hlohlona, bofubelu, kapa ho ruruha a ka hlaha ha a pepesehetse lihlahisoa tse nang le hypromellose.
Ho halefa ha Ocular: Marotholi a mahlo a nang le hypromellose a ka baka ho teneha hanyenyane, ho chesa, kapa ho hlaba ha ho kenngoa.
Matšoenyeho a Mafu: Maemong a sa tloaelehang, meriana ea molomo e nang le hypromellose e ka baka matšoao a ka mpeng a kang ho nyekeloa ke pelo, ho phunya, kapa letšollo.
Hypromellose ke polymer e feto-fetohang e nang le lits'ebetso tse fapaneng tsa meriana, ho kenyeletsoa liforomo tsa litekanyetso tse tiileng tsa molomo, litokisetso tsa mahlo, le li-topical formulations. E ntlafatsa litšobotsi tsa sehlahisoa tse kang viscosity, botsitso, le bioavailability, ho ntlafatsa phano ea lithethefatsi le ho mamela mokuli. Leha e na le ts'ebeliso e atileng le boemo bo botle ba polokeho ka kakaretso, batho ba nang le hypersensitivity ho lintho tse tsoang ho cellulose ba lokela ho sebelisa lihlahisoa tse nang le hypromellose ka hloko. Ka kakaretso, hypromellose e bapala karolo ea bohlokoa mekhoeng ea sejoale-joale ea meriana, e kenya letsoho katlehong le polokehong ea meriana le lihlahisoa tsa bophelo bo botle.
Nako ea poso: Mar-01-2024