Hydroxypropylmethylcellulose (HPMC) ke polymer e sebetsang ka bongata e nkiloeng ho selulose e sebelisoang haholo liindastering tse fapaneng ka lebaka la thepa ea eona e ikhethang. Motsoako ona o entsoe ka letoto la liphetoho tsa lik'hemik'hale ho cellulose, polymer ea tlhaho e fumanehang maboteng a lisele tsa semela.
lisebelisoa tse so ntlafatsoe:
Mohloli: Cellulose ke thepa e ka sehloohong e tala ea HPMC, e nang le tlhaho e ngata ebile e ntšoa limela. Lithako tsa lehong le lithara tsa k'hothone ke mehloli e atileng haholo ea selulose.
Ho itšehla thajana: Ts'ebetso ea ho ntšoa e kenyelletsa ho heletsa mabota a lisele tsa semela le ho arola likhoele tsa cellulose. Mekhoa e fapaneng ea lik'hemik'hale le ea mechine e ka sebelisoa molemong ona.
Propylene oxide:
Mohloli: Propylene oxide ke motsoako oa manyolo o tsoang mehloling ea petrochemical.
Mosebetsi: Propylene oxide e sebelisetsoa ho hlahisa lihlopha tsa hydroxypropyl ka limolek'hule tsa cellulose nakong ea ts'ebetso ea ho kopanya, ho ntlafatsa ho qhibiliha ha metsi le ho fetola thepa ea 'mele ea HPMC e hlahisoang.
Methyl chloride:
Mohloli: Methyl chloride ke hydrocarbon e chlorinated e ka etsoang ho tloha methanol.
Mosebetsi: Methyl chloride e sebelisetsoa ho hlahisa lihlopha tsa methyl ka limolek'hule tsa cellulose, tse tlatsetsang ho hydrophobicity ea HPMC.
Sodium hydroxide (NaOH):
Mohloli: Sodium hydroxide, eo hape e tsejoang e le caustic soda, ke setsi se matla 'me se fumaneha khoebong.
Mosebetsi: NaOH e sebelisetsoa ho susumetsa karabelo le ho lokisa boleng ba pH ba motsoako oa karabelo nakong ea ts'ebetso ea ho kopanya.
Synthesis:
Kakaretso ea HPMC e kenyelletsa mehato e mengata, mme leano la karabelo le ka akaretsoa ka tsela e latelang:
Alkalizing:
Cellulose e tšoaroa ka sodium hydroxide ho hlahisa selulose ea alkaline.
Alkali cellulose joale e sebetsanoa le propylene oxide ho hlahisa lihlopha tsa hydroxypropyl.
Methylation:
Hydroxypropylated cellulose e tsoela pele ho arabela ka methyl chloride ho hlahisa lihlopha tsa methyl.
Mohato ona o fa polymer botsitso bo eketsehileng le hydrophobicity.
Neutralization le sefa:
The itsoara joang ka motsoako ne neutralized ho tlosa feteletseng botlaaseng.
Ho hloekisoa ho ile ha etsoa ho arola cellulose e fetotsoeng.
Ho hlatsoa le ho omisa:
Sehlahisoa se arohaneng se hlatsuoa ebe se omisoa ho fumana hydroxypropyl methylcellulose ka phofo kapa foromo ea granular.
Ho qhibiliha ha HPMC:
HPMC ha e qhibilihe ka metsing 'me ho qhibiliha ha eona ho ka fetoloa ho ea ka tekanyo ea ho fetola lihlopha tsa hydroxypropyl le methyl.
Bokhoni ba ho etsa lifilimi:
HPMC e etsa lifilimi tse feto-fetohang, tse pepeneneng tse loketseng lits'ebetso indastering ea meriana le ea lijo.
Viscosity:
Viscosity ea tharollo ea HPMC e ka laoloa 'me hangata e sebelisoa e le ntho e teteaneng le ea gelling ka litsela tse sa tšoaneng.
Thermal gelation:
Likarolo tse ling tsa HPMC li bonts'a thepa ea thermogelling, e etsa gel ha e futhumala le ho khutlela tharollong ha e pholisitsoe.
Ts'ebetso ea bokaholimo:
HPMC e ka sebelisoa joalo ka surfactant, 'me ts'ebetso ea eona e holim'a metsi e angoa ke tekanyo ea ho nkela sebaka.
Lithethefatsi tse sebelisitsoeng tsa HPMC:
HPMC e sebelisoa haholo mekhoeng ea meriana e le li-binders, disintegrants, le li-agents tse laoloang tsa tokollo matlapeng le li-capsules.
Indasteri ea kaho:
Lefapheng la kaho, HPMC e sebelisoa e le motenya lihlahisoa tse thehiloeng ho samente joalo ka seretse le sekhomaretsi sa lithaele.
indasteri ea lijo:
HPMC e sebediswa indastering ya dijo e le seteifatsi, emulsifier le stabilizer dihlahiswang tse fapaneng, ho kenyeletswa disoso, disaesepe le ice cream.
Lihlahisoa tsa tlhokomelo ea motho ka mong:
Ka litlolo le lihlahisoa tsa tlhokomelo ea botho, HPMC e sebelisoa ho etsa litlolo tse kang litlolo, litlolo le li-shampoo ka lebaka la ho tenya le ho tsitsisa ha eona.
Lipente le Liaparo:
HPMC e eketsoa lipenteng le lirapeng ho laola viscosity, ho ntlafatsa thepa ea kopo le ho ntlafatsa thepa ea ho etsa lifilimi.
Litharollo tsa Ophthalmic:
HPMC e sebelisoa marotholing a mahlo le meokho ea maiketsetso ka lebaka la ho lumellana ha eona le lintho tse kopanyang mucoadhesive.
ha re phethela:
Hydroxypropylmethylcellulose (HPMC) ke polima e makatsang e entsoeng ho tsoa ho selulose ea lisebelisoa tse nchafalitsoeng. Lintho tsa eona tse nang le mesebetsi e mengata le mefuta e mengata ea likopo li etsa hore e be motsoako oa bohlokoa liindastering tse fapa-fapaneng, ho tloha ho meriana ho ea kahong le lijong. Ka khetho e hlokolosi ea lisebelisoa tse tala le taolo ea li-parameter tsa synthesis, li-HPMC tse nang le thepa e ikhethileng li ka hlahisoa ho fihlela litlhoko tse ikhethang tsa lits'ebetso tse fapaneng. Ha thekenoloji le litlhoko li ntse li tsoela pele ho fetoha, HPMC e kanna ea lula e le sebapali sa bohlokoa ho boqapi le nts'etsopele ea lihlahisoa tse tsitsitseng ho pholletsa le liindasteri.
Nako ea poso: Dec-18-2023