Hydroxypropyl methylcellulose (HPMC, Hydroxypropyl Methylcellulose) ke ether ea bohlokoa ea cellulose, e sebelisoang haholo ho haha, meriana, lijo le masimo a mang, 'me e tloaelehile ka ho khetheha ho thepa ea mohaho. Poloko ea metsi ea HPMC ke e 'ngoe ea thepa ea eona ea bohlokoa' me e bapala karolo ea bohlokoa katlehong ea maemo a mangata a ts'ebeliso. Lintho tse amang ho bolokoa ha metsi ha HPMC li kenyelletsa sebopeho sa limolek'hule, tekanyo ea ho fetola, boima ba limolek'hule, solubility, mocheso o teng, li-additives, joalo-joalo.
1. Sebopeho sa limolek'hule
HPMC ke karolo e tsoang ho cellulose eo sebopeho sa eona sa molek'hule se nang le tšusumetso e kholo ho bolokeng metsi. Sebopeho sa molek'hule sa HPMC se na le hydrophilic hydroxyl (-OH), lipophilic methyl (-CH₃) le hydroxypropyl (-CH₂CHOHCH₃). Karolo le kabo ea lihlopha tsena tsa hydrophilic le lipophilic li na le phello e tobileng ts'ebetsong ea ho boloka metsi ea HPMC.
Karolo ea lihlopha tsa hydroxyl: Lihlopha tsa Hydroxyl ke lihlopha tsa hydrophilic tse ka etsang li-hydrogen bond ka limolek'hule tsa metsi, kahoo li thusa ho ntlafatsa ho boloka metsi a HPMC.
Karolo ea lihlopha tsa methyl le hydroxypropyl: Lihlopha tsena li na le hydrophobic 'me li ka ama mocheso oa solubility le gelation oa HPMC metsing, kahoo e ama ts'ebetso ea ho boloka metsi.
2. Degree ea ho nka sebaka
The degree of substitution (DS) e bolela palo e tloaelehileng ea lihlopha tsa hydroxyl tse nketsoeng sebaka ka limolek'hule tsa cellulose. Bakeng sa HPMC, tekanyo ea ho fetola methoxy (-OCH₃) le hydroxypropoxy (-OCH₂CHOHCH₃) hangata e ameha, ke hore, tekanyo ea substitution ea methoxy (MS) le tekanyo ea ho fetola hydroxypropoxy (HP):
Boemo bo phahameng ba phapanyetso: Ha maemo a phahamisoa a phahame, lihlopha tsa HPMC li na le hydrophilic haholoanyane, 'me ho nahanoa hore ho boloka metsi ho tla ntlafatsoa. Leha ho le joalo, ho nka sebaka se phahameng haholo ho ka lebisa ho solubility e feteletseng, 'me phello ea ho boloka metsi e ka fokotseha.
Tekanyo e tlaase ea ho fetola: HPMC e nang le tekanyo e tlaase ea ho fetola e na le ho qhibiliha ho fokolang metsing, empa mohaho oa marang-rang o entsoeng o ka ba o tsitsitseng haholoanyane, kahoo o boloka metsi a betere.
Ho fetola tekanyo ea ho kenya sebaka ka har'a mefuta e itseng ho ka ntlafatsa ho boloka metsi a HPMC. Maemo a tloaelehileng a li-degree tsa substitution hangata ke 19-30% bakeng sa methoxy le 4-12% bakeng sa hydroxypropoxy.
3. Boima ba molek'hule
Boima ba limolek'hule tsa HPMC bo na le tšusumetso e kholo ho bolokeng metsi a eona:
Boima bo phahameng ba limolek'hule: HPMC e nang le boima bo phahameng ba molek'hule e na le liketane tse telele tsa molek'hule 'me e theha sebopeho sa marang-rang se teteaneng, se ka khonang ho amohela le ho boloka metsi a mangata, kahoo ho ntlafatsa ho boloka metsi.
Boima bo tlase ba limolek'hule: HPMC e nang le boima bo tlase ba limolek'hule e na le limolek'hule tse khuts'oane le bokhoni bo batlang bo fokola ba ho boloka metsi, empa e na le ho qhibiliha ho hotle ebile e loketse lits'ebetso tse hlokang ho qhibiliha kapele.
Ka tloaelo, mefuta ea boima ba limolek'hule ea HPMC e sebelisoang ho thepa ea mohaho e tloha ho 80,000 ho ea ho 200,000.
4. Sollubility
The solubility ea HPMC e ama ka ho toba ho boloka metsi a eona. Sollubility e ntle e thusa HPMC hore e qhalane ka botlalo ka har'a matrix, ka hona e etsa sebopeho se ts'oanang sa ho boloka metsi. Sollubility e angoa ke:
Mocheso oa ho qhibiliha: HPMC e qhibiliha butle metsing a batang, empa e qhibiliha ka potlako metsing a futhumetseng. Leha ho le joalo, mocheso o phahameng haholo o tla etsa hore HPMC e qhalane haholo, e ama sebopeho sa eona sa ho boloka metsi.
pH boleng: HPMC e na le kutloelo-bohloko ho boleng ba pH mme e na le ho qhibiliha ho betere libakeng tse sa nke lehlakore kapa tse nang le asiti e fokolang. E ka 'na ea theola kapa ea fokotsa ho qhibiliha tlas'a litekanyetso tse feteletseng tsa pH.
5. Mocheso oa tikoloho
Mocheso o na le tšusumetso e kholo ho bolokoeng ha metsi ho HPMC:
Mocheso o tlaase: Ka mocheso o tlaase, ho qhibiliha ha HPMC ho fokotseha, empa viscosity e phahame, e ka etsang mohaho o tsitsitseng oa ho boloka metsi.
Mocheso o phahameng: Mocheso o phahameng o potlakisa ho qhibiliha ha HPMC, empa o ka baka tšenyo mohahong o bolokang metsi le ho ama phello ea oona ea ho boloka metsi. Ka kakaretso, ho boloka metsi hantle ho ka bolokoa ka tlase ho 40 ℃.
6. Lisebelisoa
HPMC hangata e sebelisoa hammoho le li-additives tse ling lits'ebetsong tse sebetsang. Li-additives tsena li ka ama ho bolokoa ha metsi ha HPMC:
Li-plasticizers: tse kang glycerol le ethylene glycol, tse ka ntlafatsang ho feto-fetoha ha maemo le ho boloka metsi a HPMC.
Li-fillers: tse kang gypsum le quartz powder, li tla ama ho boloka metsi a HPMC le ho fetola litšobotsi tsa eona tsa ho hasana le ho qhalana ka ho sebelisana le HPMC.
7. Maemo a kopo
Ts'ebetso ea ho boloka metsi ea HPMC le eona e tla ameha tlasa maemo a fapaneng a ts'ebeliso:
Maemo a kaho: joalo ka nako ea kaho, mongobo oa tikoloho, joalo-joalo a tla ama phello ea ho boloka metsi ea HPMC.
Chelete ea tšebeliso: Palo ea HPMC e ama ka kotloloho ho bolokoa ha metsi. Ka kakaretso, HPMC e nang le litekanyetso tse phahameng e bonts'a phello e ntle ea ho boloka metsi ka seretseng sa samente le lisebelisoa tse ling.
Ho na le lintlha tse ngata tse amang ho bolokoa ha metsi a HPMC, ho kenyelletsa sebopeho sa eona sa limolek'hule, tekanyo ea phetoho, boima ba limolek'hule, solubility, mocheso o teng, li-additives, le maemo a sebele a kopo. Nakong ea ts'ebetso ea kopo, ka ho khetha le ho lokisa lintlha tsena ka bohlale, ts'ebetso ea ho boloka metsi ea HPMC e ka ntlafatsoa ho fihlela litlhoko tsa masimo a fapaneng.
Nako ea poso: Jun-24-2024