Hydroxypropyl methylcellulose (HPMC) ke polymer e sebetsang ka mefuta e mengata e sebelisoang liindastering tse fapaneng tse kenyelletsang tsa meriana, kaho, lijo le litlolo. Ke motsoako oa cellulose o bonts'ang mefuta e mengata ea thepa ho latela sehlopha sa eona se ikhethileng. Limaraka tse fapaneng tsa HPMC li khetholloa haholo ka viscosity ea tsona, tekanyo ea ho fetola, boholo ba likaroloana, le sepheo se itseng sa kopo.
1. Sehlopha sa Viscosity
Viscosity ke parameter ea bohlokoa e hlalosang boemo ba HPMC. E bua ka botenya kapa ho hanyetsa ho phalla ha tharollo ea HPMC. HPMC e na le sebaka sa viscosity ho tloha tlase ho ea holimo 'me hangata e lekanngoa ka centipoise (cP) ha e qhibiliha metsing. Likarolo tse ling tse tloaelehileng tsa viscosity li kenyelletsa:
Limaraka tse tlase tsa viscosity (mohlala, 3 ho isa ho 50 cP): Limaraka tsena li sebelisoa lits'ebetsong tse hlokang tharollo ea viscosity e tlase, joalo ka indastering ea lijo joalo ka li-stabilizers, thickeners, kapa emulsifiers.
Likereiti tse mahareng tsa viscosity (mohlala, 100 ho isa ho 4000 cP): Viscosity e mahareng HPMC e sebelisoa mefuteng e laoloang ea tokollo ea lithethefatsi le joalo ka litlama tlhahiso ea matlapa.
Limaraka tse phahameng tsa viscosity (mohlala, 10,000 ho ea ho 100,000 cP): Limaraka tse phahameng tsa viscosity li atisa ho sebelisoa ha ho hahoa, haholo-holo lirekere tse thehiloeng ho samente, li-adhesive le li-plaster, moo li ntlafatsang ho sebetsa, ho boloka metsi le ho khomarela.
2. Degree of Substitution (DS) le Molar Substitution (MS)
Tekanyo ea ho nka sebaka e bolela palo e tloaelehileng ea lihlopha tsa hydroxyl ho molek'hule ea cellulose tse nkeloang sebaka ke lihlopha tsa methoxy (-OCH3) kapa hydroxypropyl (-OCH2CHOHCH3). Tekanyo ea ho nka sebaka e ama ho solubility, mocheso oa gelation, le viscosity ea HPMC. Limaraka tsa HPMC li arotsoe ho ipapisitsoe le litaba tsa methoxy le hydroxypropyl:
Methoxy content (28-30%): Lintho tse phahameng tsa methoxy hangata li fella ka mocheso o tlase oa gelation le viscosity e phahameng.
Likahare tsa Hydroxypropyl (7-12%): Ho eketsa litaba tsa hydroxypropyl ka kakaretso ho ntlafatsa ho qhibiliha ha metsi a batang le ho eketsa maemo a bonolo.
3. Kabo ea boholo ba likaroloana
Boholo ba likaroloana tsa phofo ea HPMC bo ka fapana haholo, bo ama sekhahla sa ho qhibiliha le ts'ebetso ea bona ts'ebetsong e itseng. Ha likaroloana li le ntle, li qhibiliha ka potlako, li etsa hore li tšoanelehe bakeng sa likopo tse hlokang ho phalla ka potlako, joalo ka indasteri ea lijo. Ha ho hahoa, ho molemo ho sebelisa limaraka tse mahoashe bakeng sa ho hasana hantle ka metsoako e omileng.
4. Limaraka tse khethehileng tsa kopo
HPMC e fumaneha ka limaraka tse fapaneng, tse etselitsoeng litlhoko tse ikhethang tsa indasteri:
Pharmaceutical grade: E sebelisoa e le binder, filimi ea pele, le e laoloang ea tokollo ka mefuta ea litekanyetso tse tiileng tsa molomo. E kopana le litekanyetso tse tiileng tsa bohloeki 'me hangata e na le viscosity e khethehileng le thepa ea ho fetola.
Kereiti ea kaho: Sehlopha sena sa HPMC se ntlafalitsoe bakeng sa tšebeliso ea samente le lihlahisoa tse thehiloeng ho gypsum. E ntlafatsa ho boloka metsi, ho sebetsa hantle, le ho khomarela lipolasetereng, lirekere le likhomaretsi tsa lithaele. Limaraka tse phahameng tsa viscosity hangata li sebelisoa sebakeng sena.
Kereiti ea lijo: HPMC ea Kereiti ea lijo e amohetsoe hore e sebelisoe joalo ka tlatsetso ea lijo (E464) 'me e ka sebelisoa e le setei, emulsifier, le stabilizer lihlahisoa tse fapaneng, ho kenyeletsoa thepa e halikiloeng le tse ling tsa lebese. E tlameha ho ikamahanya le melao ea polokeho ea lijo 'me hangata ha e na litšila.
Sehlopha sa Cosmetic: Lihlahisoa tsa tlhokomelo ea motho ka mong, HPMC e sebelisoa e le ntho e teteaneng, emulsifier le filimi ea pele. E fana ka sebopeho se boreleli ho litlolo, litlolo le li-shampoo.
5. Limaraka tse fetotsoeng
Lisebelisoa tse ling li hloka limaraka tse fetotsoeng tsa HPMC, moo polymer e fetotsoeng ka lik'hemik'hale ho ntlafatsa thepa e itseng:
HPMC e amanang le Cross-linked: Phetoho ena e ntlafatsa matla a gel le botsitso mefuteng ea tokollo e laoloang.
Hydrophobic modified HPMC: Mofuta ona wa HPMC o sebediswa metswakong e hlokang matla a ho thibela metsi, jwalo ka dilae le dipente.
6. Likarolo tsa mocheso oa gel
Thempereichara ea gel ea HPMC ke mocheso oo tharollo e qalang ho etsa gel. E itšetlehile ka tekanyo ea ho fetola le viscosity. Limaraka tse fapaneng li fumaneha ho latela mocheso o lakatsehang oa gel:
Lithempereichara tse tlase tsa mocheso oa li-gel: Mekhahlelo ena ea li-gel li mochesong o tlase, e leng se etsang hore li tšoanele maemo a leholimo a chesang kapa mekhoa e itseng ea indasteri e hlokang maemo a tlase a mocheso.
Likarolo tse phahameng tsa mocheso oa li-gel: Tsena li sebelisoa lits'ebetsong tse hlokang ho etsoa ha li-gel ka mocheso o phahameng, joalo ka mefuta e itseng ea meriana.
HPMC e fumaneha ka limaraka tse fapaneng ho fihlela litlhoko tse ikhethang tsa liindasteri tse fapaneng. Khetho ea kereiti ea HPMC e ipapisitse le viscosity e lakatsehang, tekanyo ea ho kenya sebaka, boholo ba likaroloana, le litlhoko tse ikhethileng tsa kopo. Hore na e sebelisoa ho tsa meriana, kaho, lijong kapa litlolong, boemo bo nepahetseng ba HPMC bo bohlokoa ho fihlela thepa le ts'ebetso e batloang sehlahisoa sa ho qetela.
Nako ea poso: Aug-27-2024