Hydroxypropyl Methylcellulose (HPMC) ke motsoako oa bohlokoa oa selulose o nang le lisebelisoa tse ngata liindastering tse ngata. E na le litšobotsi tse ntle tsa 'mele le lik'hemik'hale, chefo e tlase, le botsoalle ba tikoloho.
1. Lintho tsa motheo tsa HPMC
Sebopeho sa lik'hemik'hale le thepa ea 'mele
HPMC ke non-ionic cellulose ether e fumanoang ka ho fetola lik'hemik'hale tsa cellulose ea tlhaho. Sebopeho sa eona sa mantlha se na le likarolo tsa tsoekere, tse theoang ka ho nkela lihlopha tse ling tsa hydroxyl sebaka ka lihlopha tsa hydroxypropyl le methyl. Sebopeho sa eona sa 'mele hangata ke phofo e tšoeu kapa e mosehla hanyenyane, e qhibilihang habonolo metsing a batang le a chesang ho etsa tharollo ea viscous e hlakileng kapa e nyenyane.
Boima ba molek'hule: HPMC e na le mefuta e mengata ea litekanyo tsa limolek'hule, ho tloha ho boima bo tlaase ba molek'hule (joaloka 10,000 Da) ho ea boima ba molek'hule e phahameng (e kang 150,000 Da), 'me thepa ea eona le lisebelisoa li boetse li fetoha ka tsela e nepahetseng.
Sollubility: HPMC e etsa motsoako oa colloidal metsing a batang, empa ha e qhibilihe ka har'a metsoako e meng ea tlhaho, 'me e na le ho qhibiliha ho hotle le botsitso.
Viscosity: Viscosity ke thepa ea bohlokoa ea HPMC, e angoang ke boima ba limolek'hule le mofuta le palo ea tse ling. High-viscosity HPMC e atisa ho sebelisoa e le motenya le stabilizer, ha HPMC e nang le viscosity e tlaase e sebelisetsoa ho etsa lifilimi le mesebetsi ea ho kopanya.
Ho tsitsa ha lik'hemik'hale
HPMC e na le botsitso bo phahameng ba lik'hemik'hale, e ka hanela khoholeho ea li-acids, alkalis le li-solvents tse tloaelehileng, 'me ha ho bonolo ho senya kapa ho senya. Sena se e lumella ho boloka mesebetsi ea eona libakeng tse sa tšoaneng tse rarahaneng 'me e loketse mefuta e mengata ea likopo tsa indasteri.
Biocompatibility
Kaha HPMC e tsoa ho selulose ea tlhaho 'me e fetotsoe ka mokhoa o itekanetseng, e na le biocompatibility e ntle le chefo e tlaase. Ka hona, hangata e sebelisoa lijong, meriana le litlolo, ho finyella litlhoko tsa tšireletso.
2. Mokhoa oa ho itokisa oa HPMC
Tokisetso ea HPMC hangata e arotsoe ka mehato e meraro:
Kalafo ea alkali: cellulose ea tlhaho e phekoloa ka tharollo ea alkali (hangata sodium hydroxide) ho e ruruha le ho eketsa ts'ebetso ea eona.
Etherification reaction: Tlas'a maemo a alkaline, selulose e kenella karabelo ea etherification ka methyl chloride le propylene oxide, e hlahisa lihlopha tsa methyl le hydroxypropyl ho theha hydroxypropyl methylcellulose.
Tlhoekiso: Li-reaction byproducts le li-reagents tse setseng li tlosoa ka ho hlatsoa, ho sefa le ho omisa ho fumana HPMC e hloekileng.
Ka ho laola maemo a karabelo (a kang mocheso, nako, karo-karolelano ea reagent, joalo-joalo), tekanyo ea ho fetola le boima ba molek'hule ea HPMC e ka fetoloa ho fumana lihlahisoa tse nang le thepa e fapaneng.
3. Makala a kopo ea HPMC
Lisebelisoa tsa ho haha
Lefapheng la kaho, HPMC e sebelisoa haholo ka seretse sa samente, lihlahisoa tsa gypsum, litlolo, joalo-joalo. Mesebetsi ea eona e ka sehloohong e kenyelletsa:
Ho tiisa le ho boloka metsi: Ka seretse le ho roala, HPMC e ka eketsa viscosity le ho ntlafatsa ts'ebetso ea kaho, ha e ntse e fana ka phello e ntle ea ho boloka metsi le ho thibela mapetsong a ho fokotseha.
Ho ntlafatsa ho khomarela: Ho matlafatsa ho khomarela pakeng tsa seretse le substrate le ho ntlafatsa boleng ba kaho.
Ho ntlafatsa thepa ea kaho: Ho etsa hore kaho ea seretse le ho roala e be bonolo, ho lelefatsa nako e bulehileng le ho ntlafatsa boreleli ba bokaholimo.
Indasteri ea meriana
Tšebeliso ea HPMC indastering ea meriana e bonahala haholo litokisetsong tsa lithethefatsi, haholo-holo matlapa a molomo le li-capsules:
Lisebelisoa tsa tokollo tse laoloang: HPMC e atisa ho sebelisoa ho lokisa matlapa a ho lokolloa a laoloang, 'me ho lokolloa butle ha lithethefatsi ho finyelloa ka ho lokisa sekhahla sa ho qhibiliha.
Li-binders tsa Letlapa: Tlhahisong ea letlapa, HPMC e ka sebelisoa e le setlamo ho fana ka boima bo loketseng ba letlapa le nako ea ho arohana.
Ho roala filimi: ho sebelisoa e le lisebelisoa tsa ho roala matlapa ho thibela oxidation le khoholeho ea mongobo ea lithethefatsi le ho ntlafatsa botsitso le ponahalo ea lithethefatsi.
Indasteri ea lijo
HPMC e sebelisoa e le tlatsetso ea lijo indastering ea lijo, e bapala karolo ea thickener, emulsifier, stabilizer, joalo-joalo:
Thickener: e sebelisoang lihlahisoa tsa lebese, li-sauces, joalo-joalo ho fana ka sebopeho se loketseng le tatso.
Emulsifier: ka lino tse tahang le ice cream, e thusa ho theha tsamaiso e tsitsitseng ea emulsified.
Filimi ea pele: ka lipompong le likuku, HPMC e sebelisetsoa ho roala le ho khantša ho ntlafatsa ponahalo le sebopeho sa lijo.
Litlolo
Ho litlolo, HPMC e sebelisoa ho lokisa li-emulsion, litlolo, li-gel, joalo-joalo:
Ho tiisa le ho tsitsisa: ka litlolo, HPMC e fana ka viscosity e nepahetseng le botsitso, e ntlafatsa sebopeho le ho ata.
Moisturizing: e ka etsa lesela le nang le mongobo holim'a letlalo ho eketsa phello ea moisturizing ea sehlahisoa.
Lik'hemik'hale tsa letsatsi le letsatsi
HPMC e boetse e sebelisoa lihlahisoa tsa letsatsi le letsatsi tsa lik'hemik'hale, tse kang li-detergents, lihlahisoa tsa tlhokomelo ea botho, joalo-joalo:
Thickener: ka li-detergents, e eketsa viscosity ea sehlahisoa ho thibela stratification.
Suspension agent/ Ketso ya ho emisa: e sebedisoang tsamaisong ya ho emisa ho fana ka botsitso bo botle ba ho emisa.
4. Melemo le liphephetso tsa HPMC
Melemo
Ho feto-fetoha ha maemo: HPMC e na le mesebetsi e mengata mme e ka bapala likarolo tse fapaneng makaleng a fapaneng, joalo ka ho tenya, ho boloka metsi, ho tsitsisa, jj.
Biocompatibility: Chefo e tlase le biocompatibility e ntle li etsa hore e loketse ho sebelisoa lijong le meriana.
E na le botsoalle tikolohong: e tsoa ho selulose ea tlhaho, e ka senyeha habonolo ebile e baballa tikoloho.
Mathata
Litšenyehelo: Ha ho bapisoa le lisebelisoa tse ling tsa maiketsetso tsa polymer, HPMC e na le litšenyehelo tse phahameng, tse ka fokotsang tšebeliso ea eona e atileng lits'ebetsong tse itseng.
Ts'ebetso ea tlhahiso: Mokhoa oa ho lokisa o kenyelletsa mekhoa e rarahaneng ea lik'hemik'hale le mehato ea ho hloekisa, e hlokang ho laoloa ka thata ho netefatsa boleng ba sehlahisoa.
5. Ditebello tsa bokamoso
Ka tsoelopele ea mahlale le thekenoloji, litebello tsa ts'ebeliso ea HPMC li pharaletseng haholo. Litaelo tsa lipatlisiso tsa nako e tlang li ka kenyelletsa:
Nts'etsopele ea HPMC e fetotsoeng: Ka phetoho ea lik'hemik'hale le theknoloji e kopantsoeng, lihlahisoa tsa HPMC tse nang le mesebetsi e itseng li ntlafatsoa ho fihlela litlhoko tse khethehileng tsa kopo.
Mokhoa oa ho lokisa botala: Batlisisa mekhoa ea ho lokisa e baballang tikoloho le e sebetsang hantle ho fokotsa litšenyehelo tsa tlhahiso le moroalo oa tikoloho.
Libaka tse ncha tsa kopo: Lekola ts'ebeliso ea HPMC masimong a ntseng a hlaha, joalo ka biomaterials, liphutheloana tse senyehang, jj.
Joaloka motsoako oa bohlokoa oa selulose, hydroxypropyl methylcellulose (HPMC) e na le thepa e ntle ea 'mele le ea lik'hemik'hale, libaka tse fapaneng tsa ts'ebeliso le ho lumellana hantle le biocompatibility. Nts'etsopele ea nako e tlang, ka boqapi ba theknoloji le katoloso ea ts'ebeliso, HPMC e lebelletsoe ho bapala melemo ea eona e ikhethang mafapheng a mangata le ho fana ka tšusumetso e ncha bakeng sa nts'etsopele ea indasteri.
Nako ea poso: Jun-25-2024