(1). Selelekela
Hydroxypropyl methylcellulose (HPMC), e tsejoang hape e le hydroxypropyl methylcellulose, ke semi-synthetic cellulose ether e nang le mefuta e fapaneng ea ts'ebeliso ea meriana. Tšebeliso ea HPMC lefapheng la meriana haholo-holo ka lebaka la thepa ea eona e babatsehang ea 'mele le ea lik'hemik'hale, ho kenyelletsa le ho etsa lifilimi, gelling, thickening, adhesion le botsitso. E le motsoako oa inert le o se nang ionic, HPMC e ka fana ka mokhoa o atlehang oa ho fana ka tokollo e laoloang, ho pata masking, ho etsa lifilimi, ho khomarela le ho sireletsa mesebetsi ho litokisetso tsa meriana.
(2). Sebopeho le tokisetso
HPMC e fetotsoe ke karolo ea methylation le hydroxypropylation ea selulose ka etherification ea selulose ka methanol le propylene oxide tlas'a maemo a alkaline. Thepa ea HPMC, joalo ka viscosity, mocheso oa gelation le solubility, e angoa ke litaba tsa eona tse ncha le boima ba limolek'hule. Tlhahiso ea sehlopha sa meriana ea HPMC e tlameha ho finyella litekanyetso tse tiileng tsa boleng ho netefatsa bohloeki le botsitso ba eona ho finyella litlhoko tsa litokisetso tsa meriana.
(3). Lintho tsa 'mele le tsa lik'hemik'hale
Thepa ea ho etsa lifilimi: HPMC e ka theha filimi e bonaletsang, e se nang mebala, e tenyetsehang.
Ho qhibiliha ha metsi: E qhibiliha ka potlako metsing a batang, empa e etsa gel metsing a chesang.
Taolo ea Viscosity: The viscosity ea tharollo ea HPMC e ka laoloa ka ho fetola mahloriso a eona le boima ba limolek'hule.
Inertness ea lik'hemik'hale: E tsitsitse ka lik'hemik'hale tlas'a maemo a mangata 'me ha e sebetsane le metsoako ea lithethefatsi.
(4). Lisebelisoa tsa meriana
4.1 Litokisetso tse laoloang tsa tokollo
HPMC e bapala karolo ea bohlokoa litokisetsong tsa tokollo e tsitsitseng le e laoloang. E ka etsa thibelo ea li-gel, ea laola sekhahla sa ho qhibiliha ha moriana, 'me ea finyella sepheo sa ho lelefatsa nako ea ho sebetsa ha moriana.
Matlapa a laoloang ka molomo: Ka ho tsoakana le lithethefatsi, e etsa matrix bakeng sa ho lokolloa butle ha moriana. E le mothusi ea ka sehloohong matlapeng a mang a sa khaotseng, HPMC e ka nosetsa butle-butle 'me ea etsa lera la gel ho laola ho lokolloa ha moriana.
Li-Microspheres le li-microcapsules: Joaloka moemeli oa ho etsa filimi kapa stabilizer ea ho emisa, e sebelisetsoa ho koahela likaroloana tsa lithethefatsi le ho fokotsa sekhahla sa ho lokolloa.
4.2 Lisebelisoa tsa ho roala
E le lisebelisoa tsa ho roala, HPMC e ka fana ka tšireletso ea lithethefatsi, ho laola ho lokolloa, ho ntlafatsa ponahalo, le ho pata monko o sa thabiseng kapa litatso.
Enteric coating: HPMC e kopantsoe le li-polymers tse ling ho etsa liphahlo tsa enteric tse hanyetsanang le lero la gastric, ho netefatsa hore moriana o lokolloa ka maleng ho e-na le ka mpeng.
Ho roala filimi: Ho roala filimi ho sebelisetsoa matlapa kapa li-granules ho ntlafatsa botsitso le matšeliso a ho metsa.
4.3 Litlamahano
Thepa e tlamang ea HPMC e e etsa setlamo se loketseng bakeng sa ho lokisa letlapa. E ka ntlafatsa compressibility ea powders le mochine matla a matlapa a.
Matlapa: A sebelisoa e le se tlamella ka granulation e metsi ho etsa bonnete ba hore phofo e ka hatelloa hore e be matlapa a matla le a tšoanang.
Litokisetso tsa Granular: HPMC e ka ntlafatsa ho ts'oana le matla a granules le ho fokotsa nako ea ho arohana.
4.4 Li-thickeners le li-suspending agents
Joaloka li-thickeners le li-suspending agents, HPMC e ka ntlafatsa botsitso le ho tšoana ha litokisetso tsa metsi.
Mekelikeli ea molomo: Ntlafatsa tatso le botsitso le ho thibela ho na ha metsoako.
Tšebeliso ea lihlooho: E sebelisoa e le sekontiri ka har'a litlolo le li-gel ho fana ka viscosity e nepahetseng le ho ama.
4.5 Lits'ebetso tsa Ophthalmic
HPMC e sebelisoa haholo litokisetsong tsa mahlo, haholo-holo meokho ea maiketsetso le li-gels tsa mahlo.
Meokho ea maiketsetso: Joaloka setlolo, e fana ka phello e phutholohileng ea mongobo 'me e imolla matšoao a mahlo a omileng.
Ophthalmic gel: E lelefatsa nako ea ho lula ha moriana sebakeng sa mahlo le ho ntlafatsa ts'ebetso.
Li-capsules tse 4.6
HPMC e ka sebelisoa ho hlahisa li-capsules tsa meroho (li-capsules tsa HPMC) e le sebaka sa li-capsules tsa gelatin, tse loketseng batho ba jang meroho kapa bakuli ba hananang le metsoako e entsoeng ke liphoofolo.
Li-capsules tsa Vegetarian: Fana ka thepa e tšoanang ea ho qhibiliha ho li-capsules tsa gelatin 'me ha li amehe ke litaba tsa boitšoaro tsa metsoako e entsoeng ke liphoofolo.
(5). Melemo
Biocompatibility: HPMC ha e na chefo ebile ha e tenehe, e loketse mefuta e fapaneng ea litokisetso tsa lithethefatsi.
Ho tsitsa ha lik'hemik'hale: Ha e sebetse ka metsoako e sebetsang ea meriana 'me e boloka ts'ebetso ea lithethefatsi.
Versatility: E ka sebelisoa ho lokolloa ho laoloang, ho roala, ho kopanya, ho tiisa le ho emisa.
E na le botsoalle tikolohong: HPMC e entsoe ka selulose ea tlhaho 'me e ka nchafatsoa hape e ka senyeha.
6. Mathata le Ditebello
Leha HPMC e na le melemo e mengata litokisetsong tsa lithethefatsi, ho boetse ho na le mathata maemong a mang. Ka mohlala, litšobotsi tsa eona tsa 'mele li ka' na tsa hloka ho ntlafatsoa ho netefatsa ho lokolloa ha lithethefatsi tse tšoanang ka bongata bo bongata ba lithethefatsi. Ntle le moo, lipatlisiso tsa nako e tlang li ka tsepamisa maikutlo ho ntlafatseng ts'ebeliso ea HPMC lits'ebetsong tse phahameng tsa phepelo ea lithethefatsi ka ho fetoloa ha limolek'hule kapa ho kopana le li-excipient tse ling ho ntlafatsa ts'ebetso ea eona.
Pharmaceutical grade hydroxypropyl methylcellulose (HPMC) e bapala karolo e ke keng ea nkeloa sebaka mekhoeng ea sejoale-joale ea meriana ka lebaka la ho feto-fetoha ha eona le litšobotsi tse ntle tsa physicochemical. Ho tloha tokollong e laoloang, ho koaheloa ho isa ho tlamahano le botenya, mofuta oa ts'ebeliso ea HPMC o pharalletse ebile oa hola. Ka tsoelopele ea thekenoloji le nts'etsopele ea meriana e mecha, HPMC e tla bapala karolo ea bohlokoa ho feta mekhoa ea nakong e tlang ea phano ea lithethefatsi.
Nako ea poso: Jun-14-2024