HydroxypropypropyLese (HPMC)e sebelisoa ka maoto ka ho fetisisa ea metsi ka lits'ebetso tse fapaneng tsa likopo, haholo-holo meriana, haholo-holo meriana, lijo le lihlahisoa tsa cosmetic. Bokhoni ba eona ba ho theha tharollo e boima, e kang gel e tsoakiloeng le metsi e etsa sehopotso se fapaneng. Litaba tsa tharollo ea kimacAcll®hpm li bapala karolo ea bohlokoa ho tsebisang tšebetsong ts'ebetso ea tsona lifokisong tse fapaneng. Ho utloisisa litšobotsi tsa viscosion tsa tharollo ea hpmc ho bohlokoa bakeng sa ho susumetsa tšebeliso ea bona indastering e fapaneng.
1. Selelekela ho Hydroxypropyl Methylcelllllulose (HPMC)
HydroxypropypropinpropyLulose ke moqapi oa maiketsetso oa cellulose. E hlahisoa ke sebaka sa cellulose se nang le lihlopha tsa hydroxypropyl le lihlopha tsa methyl. Karolelano ea libaka tsena li ka fapana, e lebisang ho limaraka tse fapaneng tsa HPMC ka litšobotsi tse ikhethileng, ho kenyelletsa le pono. Sebopeho se tloaelehileng sa HPMC se na le mokokotlo oa selefounu le Hydropypropyl le lihlopha tsa methyl li hokahantsoe le likarolo tsa glucose.
HPMC e sebelisoa indasteri ea mefuta e fapaneng ka lebaka la ho se bina le ho se tšoanelehe, bokhoni ba ho theha lihlekehleke, le ho phomola ha li-soltubili ka metsing. Ka litharollo tse thata, HPMC li sebetsa joalo ka sets'oants'o se seng sa ionic, se qholotsang metsi molemong oa litumelo tsa tharollo, haholo.
2. Litšobotsi tsa liketsahalo tsa HPMC
Litaba tsa mathata a HPMC li susumetsoa ke lintlha tse 'maloa, ho kenyelletsa le khatello ea limompe, mocheso le liroboto tse ling. Ka tlase ke lintlha tsa mantlha tse laolang litšobotsi tsa liketsahalo tsa HPM li lithabeng tsa metsi:
TLHOKOMELISO EA HPMCViscosity e eketseha ha khatello ea HPMC e ntse e eketseha. Maemong a phahameng, limolek'hule tsa HPMC li sebetsana le tsona haholo, li lebisang khanyetso e phahameng haholo ho phalla.
Boima ba limok'hule ba hpmcViscos of HpMitions Tharollo e kopane ka matla le boima ba limokele tsa polymer. Boholo ba lipalesa tsa 'mala tsa hpmc li tloaetse ho hlahisa tharollo e eketsehileng. Sena ke hobane limolek'hule tse kholo tsa Polymer li baka ho hanyetsa haholo ho phalla ka lebaka la ho kena ha bona ho eketsehileng le likhohlano.
Mocheso: Vecosity hangata e fokotseha ha mocheso o ntse o eketseha. Sena ke hobane mocheso o phahameng o fella ka ho fokotsa bongata bo pakeng tsa limolek'hule tsa HPMC, ka hona a fokotsa bokhoni ba bona ba ho hanela phallo ea bona.
SekeselaKelello ea Tharollo ea HPMC e itšetlehile ka sekhahla, haholo-holo ho maro a sa Newtonia, a tloaelehileng tharollo ea polymer. Ka litekanyetso tse tlase tsa li-Shear, tharollo ea HPMC e bontša liketsahalo tse phahameng, ha li ntse li eketseha ka lebaka la boitšoaro bo fokotseha ka lebaka la sebete.
Kaho ea Matla a Ionic: Ho ba teng ha li-electrolytes (joalo ka letsoai) ka tharollo li ka fetola pono. Lijo tse ling li ka hlahloba mabotho a mangata pakeng tsa liketane tsa polymer, li etsa hore li atlehe ebile li felloe ke ho fokotseha ha lipono.
3. Viscosity vs. Potlako ea liteko
Kakaretso ea tloaelo e shebane le liteko ke hore pono ea hpmc e atile e eketsa ka bongata ka ho eketsa polymer. Kamano pakeng tsa viscosion le khatello ea maikutlo e ka hlalosoa ke equriringcation ea puso, eo hangata e sebelisetsoang litharollo tse tsepamisitsoeng.
long = acn \
Moo:
η η ho ratoa ke pono
CCC ke khatello ea HPMC
AAA le NNN ke li-cornant ea borena e itšetlehileng ka mofuta o itseng oa HPMC le maemo a tharollo.
Bakeng sa metenya e tlase, kamano ea bona ea mela, empa joalo ka boemo bo phahameng, vicosity e ntse e eketseha ka kelello, e bonahatsang tšebelisano e eketsehileng lipakeng tsa li-clymer chiins.
4. Viscosity vs. Molecular Boima
Boima ba limolek'hule ba kimacell®hpmc ba bapala karolo ea bohlokoa litšobotsi tsa eona tsa pono. Li-polymer tse phahameng tsa limolek'hule tsa hpmc li ka etsa tharollo e eketsehileng ka har'a limaraka tse tlase tse bapisoang le limaraka tse tlase tsa molek'hule. Litaba tsa tharollo e entsoeng ka limompe tsa molecular-boima li ka ba le litaelo tse 'maloa tse phahameng ho feta tse entsoeng ka litharollo tse entsoeng ka li-solecular-boima ba hpmc.
Mohlala, tharollo ea HPMC e nang le boima ba limok'hule ea 100,000 e tla bonts'a pono e phahameng ho feta e le 'ngoe ea 50 000 dwa.
5. Tšusumetso ea mocheso inscosity
Mocheso o na le phello e kholo ho viscoution ea tharollo ea HPMC. Keketseho ea mocheso o lebisa phokotsong ea maikutlo a tharollo. Sena se bakoa haholo-holo se futhumetseng sa liketane tsa polymer, tse etsang hore ba tsamaye ka bolokolohi, ba fokotsa ho phalla ha bona ho phalla. Kameho ea mocheso ka Viscosy hangata e hakanngoa hore u sebelisa mofuta oa mofuta oa arhenius:
η (t) = η_0 e "\
Moo:
η (t) \ eta (t) w (t) ke pono ka mocheso
η0 \ eta_0
EA_A, ke matla a ts'ebetso
RRR ke khase khafetsa
TTT ke mocheso o felletseng
6. Boitšoaro ba Rheology
Rheology of HPMC ea metsi e hlalosoang hangata e hlalosoa e le se seng sa sejoale-joale, se bolelang hore lipono tsa tharollo ha li sa khaotse empa li fapana ka sekhahla se sebelisitsoeng. Ka litekanyetso tse tlase tsa Shear, tharollo ea HPMC e bontša liketsahalo tse phahameng haholo ka lebaka la ho kenella ka liketane tsa li-clymer chiins. Leha ho le joalo, joalo ka ha Shear Shear ke eketseha, viscosions ea fokotseha, ketsahalo e tsejoang ka hore e be e tšesaane.
Boitšoaro bona bo boholo ke mokhoa o tloaelehileng oa tharollo ea polymer, ho kenyelletsa hpmc. Boemo ba likhechana bo itšetlehe ba pono ea pono e ka hlalosoa ho sebelisa mohlala oa matla:
η (Γ (γcern
Moo:
cE: \ Dot {\ gamma}}} }3
Kkk ke index ea ho bala
NNN ke index ea phallo ea phallo ea phallo ea phallo (e nang le n <1n <1n <1 bakeng sa shear e nyenyefatsang)
7. Viscosity of HpMC Tharollo: tafole ea kakaretso
Ka tlase ho na le tafole e akaretsang litšobotsi tsa li-viscosion tsa tharollo ea HPMC e nang le maemo a fapaneng:
| Paramente | Tšusumetso ea Viscosity |
| TLHOKOMELISO | E eketsa litšoantšo joalo ka khatello ea maikutlo |
| Boima ba Molecular | Boima bo phahameng ba molek'hale bo eketsa incecosity |
| Mocheso | E eketsa mocheso e fokotsa ho tšoaea |
| Sekesela | Sekhahla se phahameng se fokotsa liketsahalo (Shear thess boits'oaro) |
| Matla a Ionic | Ho ba teng hoa letsoai ho ka fokotsa liketsahalo ka ho hlahlobisisa mabotho a hlakomang pakeng tsa li-polymer chiins |
| Mohlala: VICSOSity ea HPMC (2% W / V) Tharollo | Viscosity (CP) |
| HPMC (tlase MW) | ~ 50-100 CP |
| Hpmc (mendium mw) | ~ 500-1,000 CP |
| HPMC (High MW) | ~ 2,000-5,000 cp |
Litšobotsi tsa li-viscosity tsaHpmcLitharollo tsa metsi tsa metsi li susumetsoa ke lintlha tse 'maloa, ho kenyeletsoa boima ba' mino, mocheso, mocheso, mocheso, mocheso, mocheso, mocheso, mocheso, mocheso, mocheso, mocheso, mocheso le sheale. HPMC ke boitsebiso bo arohaneng haholo, 'me thepa ea bona ea litšila e ka tsamaisoa bakeng sa likopo tse khethehileng ka ho fetola lipara tsena. Ho utloisisa lintlha tsena ho fa tšebeliso e nepahetseng ea Kimacell® indastering e fapaneng, ho tsoa ho meriana ho lijo le litlolo. Ka ho thella maemo a tlase ao HPMC a qhibilihileng, baetsi ba libapali ba ka fihlela thepa eo e batlang e le ea limpimpi tsa bona tsa litlhoko tsa bona tse khethehileng.
Nako ea ho romella: Jan-27-2025