Hydroxypropyl methylcellulose ke polima e tloaelehileng e qhibilihang ka metsing e etsang tharollo e hlakileng le e tsitsitseng metsing 'me e sebelisoa haholo indastering ea meriana, ea lijo le ea kaho. Ke thepa e tala e se nang ionic cellulose e ntlafatsang maqhama le thepa e kopanetsoeng ea sehlahisoa sa ho qetela. E le ho netefatsa ts'ebetso ea boleng bo phahameng ba hydroxypropyl methylcellulose, sehlahisoa se hloka ho hlahlojoa le ho tšoaneleha pele se sebelisoa. Sehloohong sena, re tla tšohla mekhoa e meraro e tšepahalang ea ho bolela boleng ba hydroxypropyl methylcellulose.
1. Teko ea viscosity
Viscosity ea hydroxypropyl methylcellulose ke paramente ea bohlokoa ho tseba boleng ba eona. Viscosity ke khanyetso ea mokelikeli ho phalla 'me e lekanngoa ka centipoise (cps) kapa mPa.s. Viscosity ea hydroxypropyl methylcellulose e fapana ho ea ka boima ba molek'hule le tekanyo ea ho fetola. Ha tekanyo ea ho kenya sebaka e phahame, e theola viscosity ea sehlahisoa.
Ho hlahloba viscosity ea hydroxypropyl methylcellulose, qhala palo e nyenyane ea sehlahisoa ka metsing 'me u sebelise viscometer ho lekanya viscosity ea tharollo. Viscosity ea tharollo e lokela ho ba ka har'a sebaka se khothalletsoang se fanoeng ke mofani oa lihlahisoa. Sehlahisoa se setle sa hydroxypropyl methylcellulose se lokela ho ba le viscosity e tsitsitseng, e leng pontšo ea bohloeki le boholo ba likaroloana tse tšoanang.
2. Teko ea ho kenya sebaka
Tekanyo ea ho nka sebaka e bolela karo-karolelano ea palo ea lihlopha tsa hydroxyl ho selulose e nketsoeng sebaka ke hydroxypropyl kapa lihlopha tsa methyl. Tekanyo ea ho nkela sebaka ke sesupo sa bohloeki ba sehlahisoa, ha tekanyo ea ho fetola e phahame, sehlahisoa se hloekile. Lihlahisoa tsa boleng bo holimo tsa hydroxypropyl methylcellulose li lokela ho ba le boemo bo phahameng ba ho nkela sebaka.
Ho lekola tekanyo ea ho kenya sebaka, titration e etsoa ka sodium hydroxide le hydrochloric acid. Fumana palo ea sodium hydroxide e hlokahalang ho fokotsa hydroxypropyl methylcellulose le ho bala tekanyo ea ho e nkela sebaka ka mokhoa o latelang:
Degree of Substitution = ([Bolumo ea NaOH] x [Molarity of NaOH] x 162) / ([Boima ba Hydroxypropyl Methyl Cellulose] x 3)
Tekanyo ea ho fapanyetsana e lokela ho ba ka har'a mefuta e khothaletsoang e fanoeng ke mofani oa thepa. Tekanyo ea ho kenya sebaka sa lihlahisoa tsa boleng bo holimo tsa hydroxypropyl methylcellulose e lokela ho ba ka har'a mefuta e khothaletsoang.
3. Teko ea ho qhibiliha
The solubility ea hydroxypropyl methylcellulose ke parameter e 'ngoe ea bohlokoa e khethollang boleng ba eona. Sehlahisoa se lokela ho qhibiliha habonolo ka metsing 'me se se ke sa etsa maqhubu kapa li-gel. Lihlahisoa tsa boleng bo holimo tsa hydroxypropyl methylcellulose li lokela ho qhibiliha kapele le ka ho lekana.
Ho etsa tlhahlobo ea solubility, qhala sehlahisoa se senyenyane ka metsing 'me u hlohlelletse tharollo ho fihlela e qhibiliha ka ho feletseng. Tharollo e lokela ho ba e hlakileng le e se nang maqhubu kapa li-gel. Haeba sehlahiswa se sa qhibidihe ha bonolo kapa se etsa makukuno kapa dijelle, sena e ka ba sesupo sa boleng bo tlase.
Qetellong, hydroxypropyl methylcellulose ke thepa e tala ea bohlokoa e sebelisoang liindastering tse fapaneng. E le ho netefatsa boleng bo phahameng ba sehlahisoa, liteko tsa viscosity, substitution le solubility li etsoa. Liteko tsena li tla thusa ho utloisisa ka ho hlaka litšobotsi tsa sehlahisoa le ho thusa ho khetholla boleng ba sona. Hydroxypropyl methylcellulose ea boleng bo holimo e na le viscosity e tsitsitseng, boemo bo phahameng ba ho fetola, 'me e qhibiliha ka potlako le ka mokhoa o ts'oanang metsing.
Nako ea poso: Jul-11-2023