Hydroxypropylmethylcellulose (HPMC) ke polymer e sebetsang ka bongata e sebelisoang haholo ho tsa meriana, lijo, litlolo le lits'ebetso tse fapaneng tsa indasteri. Ts'ebetso ea eona e amana haufi-ufi le thepa ea eona ea viscosity, e bapalang karolo ea bohlokoa ho khethollang ts'ebetso ea eona mekhoeng e fapaneng. Sengoliloeng sena se lekola bohlokoa ba viscosity ts'ebetsong ea HPMC, se bua ka phello ea eona ho thepa ea bohlokoa joalo ka ho tenya, ho hlopha, ho theha lifilimi, le tokollo e tsitsitseng.
Hydroxypropylmethylcellulose (HPMC) ke semi-synthetic polymer e nkiloeng ho selulose mme e fetotsoe ka karabelo ea lik'hemik'hale. E na le mefuta e mengata ea likopo ka lebaka la thepa ea eona e ikhethang, ho kenyelletsa le ho qhibiliha ha metsi, bokhoni ba ho etsa lifilimi le tlhaho e seng ea ionic. Har'a thepa ea eona e fapaneng, viscosity ke parameter ea bohlokoa e amang ts'ebetso ea eona lits'ebetsong tse fapaneng.
1.HPMC mosebetsi oa viscosity:
1.1 Ho tiisa:
E 'ngoe ea mesebetsi ea mantlha ea HPMC mefuteng e mengata ke ho tenya. The viscosity ea tharollo ea HPMC e amana ka ho toba le bokhoni ba eona ba ho eketsa viscosity ea sebaka se potolohileng. Limaraka tsa HPMC tsa viscosity e phahameng li sebelisoa hangata lits'ebetsong tse tenya joalo ka lipente, likhomaretsi le lihlahisoa tsa tlhokomelo ea motho. Phello e teteaneng e bakoa ke bokhoni ba polima ho kopanya le ho etsa marang-rang ka har'a solvent, kahoo e sitisa ho phalla ha seaplane.
1.2 Ho fepa:
Ntle le ho tenya, HPMC e ka boela ea bonts'a thepa ea gelling tlasa maemo a itseng. Boitšoaro ba gelation bo amana haufi-ufi le viscosity ea tharollo ea HPMC. Limaraka tse phahameng tsa viscosity li atisa ho theha li-gel tse matla le ho ba le botsitso bo boholo. Gelation e bohlokoa ka ho khetheha mekhoeng ea meriana, moo HPMC e sebelisetsoang ho etsa matrices a lokolotsoeng a laoloang kapa ho fana ka viscosity ka li-gel le litlolo tsa lihlooho.
1.3 Sebopeho sa lifilimi:
HPMC e sebelisoa haholo ha ho etsoa liphahlo, lifilimi le encapsulation ka lebaka la bokhoni ba eona ba ho etsa lifilimi. The viscosity ea tharollo ea HPMC e ama haholo mokhoa oa ho etsa lifilimi. Bakeng sa lits'ebetso tse hlokang lifilimi tse teteaneng tse nang le matla a betere a mochini le thepa ea lithibelo, limaraka tse holimo tsa viscosity lia khethoa. Sebopeho sa lifilimi tse tsoelang pele tse ts'oanang li itšetlehile ka viscosity ea tharollo ea polymer le bokhoni ba eona ba ho hasana ka mokhoa o ts'oanang holim'a substrate.
1.4 Tokollo e tsitsitseng:
Meetsong ea meriana, HPMC hangata e sebelisoa e le matrix ea pele bakeng sa mefuta e laoloang ea litekanyetso tsa tokollo. Sekhahla sa ho lokolloa ha motsoako o sebetsang ho tloha matrix se angoa ke viscosity ea tharollo ea HPMC. Limaraka tse phahameng tsa viscosity li etsa hore ho be le sekhahla sa ho lokolloa butle ho tloha matrix hobane ho ata ha limolek'hule tsa lithethefatsi ka matrix a polymer e ruruhileng ho sitisoa. Sena se nolofalletsa ho etsoa ha liforomo tsa tokollo ea nako e telele tse nang le lintlha tse atolositsoeng tsa tokollo ea lithethefatsi.
2. Lintlha tse amang HPMC viscosity:
Lintlha tse 'maloa li ka ama viscosity ea tharollo ea HPMC, ho kenyelletsa:
Boima ba Molek'hule: Limaraka tsa HPMC tsa boima bo phahameng ba limolek'hule hangata li bonts'a li-viscosity tse phahameng ka lebaka la ketane e ntseng e eketseha.
Degree of substitution: Tekanyo ea ho nkela sebaka sa hydroxypropyl le lihlopha tsa methyl ho ketane ea mantlha ea cellulose e ama ho qhibiliha le viscosity ea HPMC.
Concentration: The viscosity ea HPMC solutions hangata e eketseha ka ho eketseha ha polymer concentration kamanong e se nang moeli.
Mocheso: Viscosity e amana le mocheso. Ha mocheso o phahame, viscosity e tla fokotseha ka lebaka la ho fokotsa ho sebelisana pakeng tsa polymer le solvent.
pH le matla a ionic: Liphetoho ho pH le matla a ionic li ka fetola solubility le viscosity ea HPMC ka ionization le liphello tse rarahaneng.
3. Laola viscosity ea HPMC:
Baetsi ba thepa ba ka laola viscosity ea tharollo ea HPMC ho fihlela sephetho se lakatsehang lits'ebetsong tse fapaneng:
Khetho ea limaraka tsa HPMC: Limaraka tse fapaneng tsa HPMC lia fumaneha ka li-viscosity tse fapaneng ho fihlela litlhoko tse ikhethileng tsa ho theha.
Ho kopanya le li-polymers tse ling: Ho kopanya HPMC le li-polymers tse ling kapa li-additives ho ka fetola viscosity ea eona le ho ntlafatsa ts'ebetso ea eona.
Fetola Boikutlo: Ho laola khatello ea maikutlo ea HPMC ha ho etsoa ho lumella phetoho e nepahetseng ea viscosity.
Taolo ea mocheso: Taolo ea mocheso e ka sebelisoa ho lokisa viscosity ea tharollo ea HPMC nakong ea ts'ebetso.
Liphetoho tsa pH le matla a ionic: Ho fetola pH le matla a ionic a sebopeho ho ka ama ho solubility le viscosity ea HPMC.
Viscosity e bapala karolo ea bohlokoa ho thibela ts'ebetso ea HPMC lits'ebetsong tse fapaneng. Ho utloisisa kamano pakeng tsa viscosity le ts'ebetso ea HPMC ho bohlokoa bakeng sa baetsi ba lihlahisoa ho rala liforomo tse sebetsang hantle. Ka ho khetha ka hloko limaraka tsa HPMC le ho laola viscosity ka maano a fapaneng, baetsi ba lihlahisoa ba ka ntlafatsa ts'ebetso ea sehlahisoa le ho fihlela litlhoko tse ikhethileng tsa kopo.
Nako ea poso: Feb-29-2024