HPMC (hydroxypropyl methylcellulose) ke motsoako oa meriana o sebelisoang hangata ho sebelisoa ha ho etsoa mefuta e fapaneng ea litekanyetso tsa meriana, ho kenyeletsoa matlapa, li-capsules le lihlahisoa tsa mahlo. E 'ngoe ea thepa ea bohlokoa ea HPMC ke viscosity ea eona, e amang thepa ea sehlahisoa sa ho qetela. Sengoliloeng sena se tla hlahloba kamano lipakeng tsa viscosity ea HPMC le mocheso le ho totobatsa litemoso tse ling tse lokelang ho nkuoa ha u sebelisa mothusi enoa.
Kamano pakeng tsa HPMC viscosity le mocheso
HPMC ke hydrophilic polymer e qhibilihang ka metsing le lihlapolli tse ling tsa polar. Ha HPMC e qhibiliha ka metsing, e etsa tharollo ea viscous ka lebaka la boima bo phahameng ba limolek'hule tsa polymer le tekanyo e phahameng ea hydrophilicity. The viscosity ea tharollo ea HPMC e angoa ke lintlha tse 'maloa, ho kenyelletsa le khatello ea polymer, mocheso oa tharollo, le pH ea solvent.
E 'ngoe ea lintlha tsa bohlokoa tse amang viscosity ea tharollo ea HPMC ke mocheso. Viscosity ea tharollo ea HPMC e fokotseha ka mocheso o ntseng o eketseha. Lebaka ke hobane lithempereichara tse phahameng, liketane tsa polymer li fetoha mokelikeli o mongata, e leng se bakang matla a fokolang a limolek'hule a tšoereng liketane tsa polymer hammoho. Ka lebaka leo, viscosity ea tharollo e fokotseha 'me metsi a tharollo a eketseha.
Kamano pakeng tsa mocheso le HPMC viscosity e ka hlalosoa ke Arrhenius equation. Arrhenius equation ke equation ea lipalo e hlalosang kamano pakeng tsa tekanyo ea lik'hemik'hale le mocheso oa tsamaiso. Bakeng sa tharollo ea HPMC, Arrhenius equation e ka sebelisoa ho hlalosa kamano lipakeng tsa viscosity ea tharollo le mocheso oa sistimi.
Arrhenius equation e fanoa ke:
k = Ae^(-Ea/RT)
moo k e leng tekanyo e tsitsitseng, A ke ntlha ea pele ho exponential, Ea ke matla a ts'ebetsong, R ke khase e tsitsitseng, 'me T ke mocheso oa tsamaiso. The viscosity ea tharollo ea HPMC e amana le lebelo la ho phalla ha solvent ka matrix a polymer, e laoloang ke molao-motheo o tšoanang le tekanyo ea lik'hemik'hale tsa lik'hemik'hale. Ka hona, Arrhenius equation e ka sebelisoa ho hlalosa kamano pakeng tsa viscosity ea tharollo le mocheso oa tsamaiso.
Lintho tseo u lokelang ho li ela hloko ha u sebelisa HPMC
Ha o sebetsa le HPMC, ho lokela ho nkuoa mehato e 'maloa ea ho itšireletsa ho etsa bonnete ba hore polymer e sebetsa ka mokhoa o bolokehileng le o sebetsang hantle. Litlhokomelo tsena li kenyelletsa:
1. Sebelisa thepa e sireletsang
Ho bohlokoa ho sebelisa lisebelisoa tsa ts'ireletso joalo ka liatlana, likhalase, le lijase tsa lab ha u tšoara HPMC. Lebaka ke hobane HPMC e ka halefisa letlalo le mahlo, mme e ka baka mathata a ho hema ha e hema. Ka hona, ho bohlokoa ho nka mehato ea ho fokotsa kotsi ea ho pepesehela li-polymers.
2. Boloka HPMC ka nepo
HPMC e lokela ho bolokoa sebakeng se phodileng, se omeletseng ho thibela ho monya ha mongobo moeeng. Sena ke hobane HPMC ke hygroscopic, ho bolelang hore e monya mongobo o tsoang tikolohong e haufi le eona. Haeba HPMC e monya mongobo o mongata haholo, e ka ama viscosity le thepa ea sehlahisoa sa ho qetela.
3. Ela hloko tlhokomelo le mocheso
Ha o theha le HPMC, etsa bonnete ba hore o ela hloko mahloriso le mocheso oa tharollo. Sena ke hobane viscosity ea tharollo ea HPMC e khethoa haholo ke lintlha tsena. Haeba mahloriso kapa mocheso o phahame haholo kapa o le tlase haholo, o tla ama viscosity le thepa ea sehlahisoa sa ho qetela.
4. Sebelisa mekhoa e nepahetseng ea ho sebetsa
Ha o sebetsana le HPMC, ho bohlokoa ho sebelisa mekhoa e nepahetseng ea ts'ebetso ho netefatsa ts'ebetso e bolokehileng le e sebetsang ea polymer. Sena se ka kenyelletsa ho sebelisa mekhoa e fokolang ea ho kopanya ho thibela ho kuta kapa ho senya polymer, kapa ho sebelisa mekhoa e nepahetseng ea ho omisa ho tlosa mongobo o feteletseng sehlahisoa sa ho qetela.
5. Hlahloba ho lumellana
Ha u sebelisa HPMC e le excipient, ke habohlokoa ho hlahloba tshebedisano le excipients tse ling le metsoako e sebetsang ha ho etsoa. Sena ke hobane HPMC e ka sebelisana le lisebelisoa tse ling ha ho etsoa, ho ama ts'ebetso le botsitso ba sehlahisoa sa ho qetela. Ka hona, ho bohlokoa ho etsa lithuto tsa tšebelisano ho tseba mathata afe kapa afe a ka bang teng pele o tsoela pele ka tlhahiso.
ha re phethela
The viscosity ea tharollo ea HPMC e angoa ke lintlha tse 'maloa, ho kenyelletsa mahloriso, mocheso le pH. Viscosity ea tharollo ea HPMC e fokotseha ka mocheso o ntseng o eketseha ka lebaka la ho tsamaea ho eketsehileng ha liketane tsa polymer. Ha o sebetsa le HPMC, ho bohlokoa ho nka mehato e nepahetseng ho netefatsa hore o sebetsana ka mokhoa o bolokehileng le o sebetsang oa polymer. Litlhokomelo tsena li kenyelletsa ho sebelisa lisebelisoa tsa ts'ireletso, ho boloka HPMC hantle, ho ela hloko mahloriso le mocheso, ho sebelisa mekhoa e nepahetseng ea ts'ebetso, le ho hlahloba ho lumellana le lisebelisoa tse ling ka foromo. Ka ho nka litemoso tsena, HPMC e ka sebelisoa e le mothusi ea sebetsang mefuteng e fapaneng ea litekanyetso tsa meriana.
Nako ea poso: Sep-25-2023