Mokhoa oa tlhahiso ea ho qoelisoa ka alkaline ke mokhoa o tloaelehileng oa ho hlahisa hydroxypropyl methyl cellulose (HPMC). Mokhoa ona o kenyelletsa karabelo ea cellulose ka sodium hydroxide (NaOH) ebe ka propylene oxide (PO) le methyl chloride (MC) tlasa maemo a itseng.
Mokhoa oa ho qoelisoa ka alkaline o na le molemo oa ho hlahisa HPMC e nang le boemo bo phahameng ba substitution (DS), e khethollang thepa ea eona e kang solubility, viscosity, le gelation. Mokhoa ona o kenyelletsa mehato e latelang:
- Tokisetso ea Cellulose
Cellulose e fumanoa mehloling ea tlhaho e kang lehong, k'hothone kapa lisebelisoa tse ling tsa semela. Selulose e qala ho hloekisoa ebe e phekoloa ka NaOH ho etsa sodium cellulose, e leng mokhoa o sebetsang oa ho hlahisa HPMC.
- Karabelo ea Sodium Cellulose ka Propylene Oxide (PO)
Joale sodium cellulose e sebetsanoa le PO ka pel'a sekontiri se kang tetramethylammonium hydroxide (TMAH) kapa sodium hydroxide (NaOH) ka mocheso o phahameng le likhatello. Karabelo e fella ka ho thehoa ha hydroxypropyl cellulose (HPC).
- Karabelo ea HPC ka Methyl Chloride (MC)
HPC e ntan'o itšoara le MC ka boteng ba catalyst e kang sodium hydroxide (NaOH) kapa hydrochloric acid (HCl). Karabelo e fella ka hore ho thehoe hydroxypropyl methyl cellulose (HPMC).
- Ho hlatsoa le ho Omisa
Kamora karabelo, sehlahisoa se hlatsuoa ka metsi ebe se omisoa ho fumana HPMC. Hangata sehlahisoa se hloekisoa ho sebelisoa letoto la mehato ea ho hloekisa le ea centrifugation ho tlosa litšila leha e le life.
Mokhoa oa ho qoelisoa ka alkaline o na le melemo e 'maloa ho feta mekhoa e meng, ho kenyelletsa le DS e phahameng le bohloeki, theko e tlase, le scalability e bonolo. Mokhoa o ka boela oa sebelisoa ho hlahisa HPMC e nang le thepa e fapaneng ka ho fetola maemo a karabelo joalo ka mocheso, khatello le mahloriso.
Leha ho le joalo, mokhoa ona o boetse o na le mefokolo. Tšebeliso ea NaOH le MC e ka baka likotsi tsa polokeho le tikoloho, 'me mokhoa oa tlhahiso o ka nka nako' me o hloka matla a mangata.
Qetellong, mokhoa oa tlhahiso ea ho qoelisoa ka alkaline ke mokhoa o sebelisoang haholo ho hlahisa HPMC. Mokhoa ona o kenyelletsa karabelo ea cellulose ka NaOH, PO, le MC tlas'a maemo a itseng, e lateloa ke ho hloekisa le ho omisa. Le hoja mokhoa ona o na le litšitiso tse itseng, melemo ea oona e etsa hore e be khetho e ratoang bakeng sa likopo tsa indasteri le tsa meriana.
Nako ea poso: Apr-23-2023