HPMC ke semi-synthetic polymer e nkiloeng ho selulose. Ka lebaka la thepa ea eona e ntle ea ho teteana, ho tsitsisa le ho etsa lifilimi, e sebelisoa haholo meriana, lijo, litlolo le liindasteri tse ling. Ho ithuta boits'oaro ba eona ba viscosity ho bohlokoa ho ntlafatsa ts'ebetso ea eona lits'ebetsong tse fapaneng.
1. Tekanyo ea viscosity:
Rotational Viscometer: Viscometer e potolohang e lekanya torque e hlokahalang ho potoloha spindle ka lebelo le sa fetoheng ha e qoelisoa ka har'a sampuli. Ka ho fapanyetsana geometry le lebelo la ho potoloha ha spindle, viscosity ka litekanyetso tse fapaneng tsa ho kuta li ka khethoa. Mokhoa ona o nolofalletsa sebopeho sa viscosity ea HPMC tlasa maemo a fapaneng.
Capillary Viscometer: Capillary viscometer e lekanya phallo ea mokelikeli ka har'a tube ea capillary tlas'a tšusumetso ea matla a khoheli kapa khatello. Tharollo ea HPMC e qobelloa ka tube ea capillary mme viscosity e baloa ho latela sekhahla sa phallo le ho theoha ha khatello. Mokhoa ona o ka sebelisoa ho ithuta HPMC viscosity ka litheko tse tlase tsa ho kuta.
2. Tekanyo ea ramatiki:
Dynamic Shear Rheometry (DSR): DSR e lekanya karabelo ea thepa ho deformation e matla ea shear. Mehlala ea HPMC e ne e le tlas'a khatello ea oscillatory shear 'me mathata a hlahisoang a ile a lekanngoa. Boitšoaro ba viscoelastic ba tharollo ea HPMC bo ka khetholloa ka ho hlahloba viscosity e rarahaneng (η *) hammoho le modulus ea polokelo (G') le tahlehelo ea modulus (G").
Liteko tsa Creep le ho hlaphoheloa: Liteko tsena li kenyelletsa ho beha lisampole tsa HPMC khatellong ea maikutlo e sa feleng kapa khatello ea nako e telele (mokhahlelo oa creep) ebe o lekola ho hlaphoheloa ka mor'a hore khatello ea maikutlo kapa khatello e fokotsehe. Boitšoaro ba ho qhekella le ho hlaphoheloa bo fana ka temohisiso mabapi le thepa ea viscoelastic ea HPMC, ho kenyeletsoa le ho senyeha ha eona le bokhoni ba ho hlaphoheloa.
3. Lithuto tsa ho ipapisa le mocheso le mocheso:
Concentration Scan: Litekanyo tsa viscosity li etsoa ho feta mefuta e mengata ea HPMC ho ithuta kamano lipakeng tsa viscosity le polymer concentration. Sena se thusa ho utloisisa katleho e kholo ea polymer le boitšoaro ba eona bo itšetlehileng ka mahloriso.
Tekanyo ea mocheso: Litekanyo tsa viscosity li etsoa ka mocheso o fapaneng ho ithuta phello ea mocheso ho HPMC viscosity. Ho bohlokoa ho utloisisa ho its'epaha ha mocheso bakeng sa lits'ebetso moo HPMCs e nang le liphetoho tsa mocheso, joalo ka metsoako ea meriana.
4. Tlhahlobo ea boima ba limolek'hule:
Size Exclusion Chromatography (SEC): SEC e arola limolek'hule tsa polymer ho latela boholo ba tsona tharollong. Ka ho sekaseka boemo ba elution, kabo ea boima ba limolek'hule ea sampole ea HPMC e ka khethoa. Ho utloisisa kamano pakeng tsa boima ba limolek'hule le viscosity ho bohlokoa ho bolela esale pele boitšoaro ba rheological ba HPMC.
5. Mohlala le Ketsiso:
Mehlala ea theoretical: Mefuta e fapaneng ea theory, joalo ka Carreau-Yasuda model, Cross model kapa power law model, e ka sebelisoa ho hlalosa boitšoaro ba viscosity ba HPMC tlasa maemo a fapaneng a ho kuta. Mefuta ena e kopanya likarolo tse kang sekhahla sa ho kuta, mahloriso le boima ba limolek'hule ho bolela ka nepo viscosity.
Computational Simulations: Computational Fluid Dynamics (CFD) ketsiso e fana ka temohisiso ka boitšoaro ba phallo ea litharollo tsa HPMC ho lijeometri tse rarahaneng. Ka ho rarolla lipalo tse laolang tsa phallo ea mokelikeli, lipapiso tsa CFD li ka bolela esale pele kabo ea viscosity le mekhoa ea phallo tlasa maemo a fapaneng.
6. Lithuto tsa in situ le in vitro:
Litekanyo tsa in-situ: Mekhoa ea in-situ e kenyelletsa ho ithuta liphetoho tsa viscosity tsa nako ea nnete tikolohong kapa ts'ebelisong e itseng. Ka mohlala, litlhahlobong tsa meriana, litekanyo tsa in situ li ka shebella liphetoho tsa viscosity nakong ea ho senyeha ha letlapa kapa ho sebelisa gel ea lihlooho.
Teko ea in vitro: Teko ea in vitro e etsisa maemo a 'mele ho lekola boitšoaro ba viscosity ea liforomo tse thehiloeng ho HPMC tse reretsoeng tsamaiso ea molomo, ea mahlo, kapa ea lihlooho. Liteko tsena li fana ka tlhaiso-leseling ea bohlokoa mabapi le ts'ebetso le botsitso ba sebopeho tlasa maemo a amanang le baeloji.
7. Theknoloji e tsoetseng pele:
Microrheology: Mekhoa ea Microrheology, joalo ka dynamic light scattering (DLS) kapa particle tracking microrheology (PTM), e lumella ho hlahloba litšobotsi tsa viscoelastic tsa maro a rarahaneng ka tekanyo ea microscopic. Mekhoa ena e ka fana ka leseli mabapi le boitšoaro ba HPMC boemong ba limolek'hule, e tlatselletsang litekanyo tsa macroscopic rheological.
Nuclear Magnetic Resonance (NMR) Spectroscopy: NMR spectroscopy e ka sebelisoa ho ithuta matla a limolek'hule le litšebelisano tsa HPMC ka tharollo. Ka ho lekola liphetoho tsa lik'hemik'hale le linako tsa ho phomola, NMR e fana ka leseli la bohlokoa mabapi le liphetoho tsa HPMC le litšebelisano tsa polymer-solvent tse amang viscosity.
Ho ithuta ka boits'oaro ba viscosity ba HPMC ho hloka mokhoa o fapaneng, ho kenyeletsoa mekhoa ea liteko, mohlala oa theory, le mekhoa e tsoetseng pele ea tlhahlobo. Ka ho sebelisa motsoako oa viscometry, rheometry, tlhahlobo ea limolek'hule, mohlala, le mekhoa e tsoetseng pele, bafuputsi ba ka fumana kutloisiso e feletseng ea thepa ea rheological ea HPMC le ho ntlafatsa ts'ebetso ea eona lits'ebetsong tse fapaneng.
Nako ea poso: Feb-29-2024