Mathata Tšebelisong ea Hydroxypropyl methylcellulose

Hydroxypropyl methylcellulose (HPMC) ke polymer e sebelisoang haholo liindastering tse fapaneng, ho kenyeletsoa indasteri ea meriana, ea lijo le ea litlolo, ka lebaka la thepa ea eona e ikhethang, joalo ka ho qhibiliha ho hoholo, botsitso ba mocheso le bokhoni ba ho etsa lifilimi. Leha ho le joalo, ho na le mathata a 'maloa a amanang le ts'ebeliso ea HPMC, e ka amang ts'ebetso le katleho ea eona. Sehloohong sena, re tla tšohla a mang a mathata a tloaelehileng ts'ebelisong ea HPMC le tharollo ea bona e ka khonehang.

1. Viscosity e sa tsitsang

E 'ngoe ea mathata a tloaelehileng ka ho fetisisa ts'ebetsong ea HPMC ke ho se lumellane ha viscosity ea tharollo. HPMC e fumaneha ka limaraka tse fapaneng, 'me viscosity ea sehlopha ka seng e ka fapana ho latela lintlha tse joalo ka boemo ba sebaka, boima ba limolek'hule le boholo ba karoloana. Ka lebaka leo, ho ka ba thata ho fumana viscosity e tsitsitseng ea tharollo ea HPMC.

Tharollo: Ho hlola bothata bona, ho bohlokoa ho sebelisa HPMC ea kereiti e ts'oanang le boleng. Baetsi ba lokela ho fana ka lintlha tse qaqileng mabapi le thepa ea lihlahisoa tsa bona tsa HPMC, tse kang mefuta ea viscosity, kabo ea boholo ba likaroloana, le tekanyo ea ho fetola, ho thusa basebelisi ho khetha kereiti e loketseng bakeng sa ts'ebeliso ea bona e khethehileng. Ho phaella moo, ho kgothaletswa ho sebelisa viscometer ho lekanya viscosity ea tharollo ea HPMC nakong ea ts'ebetso ea ho lokisetsa ho netefatsa ho tsitsisa.

2. Ho fokola ho qhibiliha

Bothata bo bong bo amanang le HPMC ke ho fokola ha solubility. HPMC ke polymer e qhibilihang ka metsing, empa ho qhibiliha ha eona ho ka angoa ke lintlha tse kang pH, mocheso, le boteng ba lisebelisoa tse ling.

Tharollo: Ho ntlafatsa ho qhibiliha ha HPMC, ho khothaletsoa ho sebelisa sehlahisoa sa boleng bo holimo sa HPMC se nang le sebaka se tlase. Sena se tla eketsa palo ea lihlopha tse fumanehang tsa hydroxyl holim'a ketane ea polymer, e tla ntlafatsa ho qhibiliha ha eona. Ho feta moo, ho bohlokoa ho sebelisa solvent e nepahetseng le ho netefatsa hore e maemong a mocheso le pH e nepahetseng. Haeba solubility ea HPMC e ntse e fokola, ho ka 'na ha hlokahala hore u sebelise surfactant kapa ntho e' ngoe ea solubilizing.

3. Ho se lumellane le li-excipients tse ling

HPMC e atisa ho sebelisoa hammoho le li-excipients tse ling ho ntlafatsa tshebetso le thepa ea sehlahisoa sa ho qetela. Leha ho le joalo, li-excipients tse ling li ka 'na tsa se ke tsa lumellana le HPMC, tse lebisang mathateng a kang karohano ea mekhahlelo, ho etsoa ha li-gel, kapa liphetoho tsa viscosity.

Tharollo: Ho qoba mathata a ho se lumellane, ho bohlokoa ho lekola tšebelisano ea HPMC le li-excipients tse ling pele o sebelisoa. Sena se ka etsoa ka ho lokisa sebopeho se senyenyane le ho shebella liphetoho leha e le life ponahalong, viscosity, kapa thepa e 'ngoe. Haeba ho se lumellane ho fumanoa, ho ka 'na ha hlokahala hore ho lokisoe sebopeho kapa ho sebelisa motsoako o fapaneng.

4. Bokhoni bo bobe ba ho etsa lifilimi

Hangata HPMC e sebelisoa e le moemeli oa ho roala bakeng sa matlapa le li-capsules ho ntlafatsa ponahalo ea tsona, botsitso le ho metsa. Leha ho le joalo, bokhoni ba ho etsa lifilimi ba HPMC bo ka angoa ke lintlha tse kang mongobo