Pharmaceutical Grade Hydroxypropyl Methylcellulose (HPMC) ke motsoako oa meriana o sebelisoang hangata, o sebelisoang haholo indastering ea meriana. Ke semi-synthetic, inert, water-soluble cellulose ether, e fetotsoeng ka lik'hemik'hale ho tloha selulose ea tlhaho. HPMC e na le thepa e ntle ea ho etsa lifilimi, e teteaneng, ea ho khomarela, ea ho emisa le e khahlanong le ho etsa li-caking, kahoo e na le bohlokoa ba kopo ea bohlokoa litokisetsong tsa meriana.
1. Lintho tsa motheo tsa HPMC
HPMC e entsoe ka ho nkela karolo ea hydroxyl ea selulose sebaka ka lihlopha tsa hydroxypropyl le methoxy. Sebopeho sa eona sa limolek'hule se na le li-substitute tse peli, hydroxypropyl le methyl, kahoo e bitsoa hydroxypropyl methylcellulose. HPMC e na le solubility e ntle ka metsing, 'me ka mor'a ho qhibiliha, e etsa tharollo e hlakileng ea viscous. Ha mahloriso a ntse a eketseha, viscosity le eona ea eketseha. Ho phaella moo, HPMC e na le botsitso bo botle ba mocheso le botsitso ba lik'hemik'hale, 'me e na le mamello e ntle ho tharollo ea acid, alkali le letsoai.
2. Tšebeliso ea HPMC ho meriana
HPMC e sebelisoa haholo indastering ea meriana, haholo-holo likarolong tse latelang:
a. Ho roala letlapa
HPMC, e le thepa ea ho roala matlapa, e ka koahela tatso e mpe ea lithethefatsi ka katleho, ea ntlafatsa ponahalo ea lithethefatsi, 'me e na le liphello tse thibelang mongobo le tse khahlanong le oxidation. Ho phaella moo, e ka lelefatsa nako ea ho lokolloa ha lithethefatsi ka har'a pampitšana ea gastrointestinal, ka tsela eo ho finyella liphello tse tsitsitseng kapa tse laoloang.
b. Li-thickeners le li-binders
Ha u lokisetsa li-suspensions, li-emulsions, capsules le litokisetso tse ling, HPMC, e le motenya le sekontiri, e ka ntlafatsa botsitso le ho tšoana ha litokisetso. Ka nako e ts'oanang, HPMC e ka boela ea ntlafatsa ho tiea le matla a mochini a matlapa ho netefatsa hore lithethefatsi ha li robehe habonolo nakong ea tlhahiso le lipalangoang.
c. Litokisetso tse laoloang le tse tšoarellang tsa tokollo
Hangata HPMC e sebelisoa litokisetsong tse laoloang-ho lokolloa le ho lokolloa ka mokhoa o tsitsitseng hobane lera la gel leo le le etsang le ka thibela metsi ho kena letlapeng, e le hore tekanyo ea ho qhibiliha le ho lokolloa ha lithethefatsi li laoloe ka katleho. Ka ho fetola li-viscosity le litekanyetso tsa HPMC, tekanyo ea ho lokolloa ha lithethefatsi e ka laoloa ka nepo, nako ea ts'ebetso ea lithethefatsi e ka lelefatsoa, 'me khafetsa ea meriana e ka fokotseha.
d. E le ho tlatsa
Litokisetsong tsa li-capsule, HPMC e ka sebelisoa e le sethapo ho tlatsa li-capsules tse se nang letho. Ha li bapisoa le li-capsules tsa gelatin tsa setso, li-capsules tsa HPMC li na le melemo ea ho tsoa limela le ho se na lisebelisoa tsa liphoofolo, kahoo li loketse batho ba jang meroho le bakuli ba nang le litloaelo tsa bolumeli.
3. Polokeho ea HPMC
Joalo ka mothusi oa meriana, HPMC e na le biocompatibility e ntle le polokeho. Ha e bolisoe ke li-enzyme tsa tšilo ea lijo 'meleng oa motho' me haholo-holo e ntšoa 'meleng ka mala, ka hona ha e kopanele ts'ebetsong ea metabolism ea lithethefatsi ebile ha e hlahise litla-morao tse chefo. HPMC e 'nile ea sebelisoa haholo litokisetsong tse fapa-fapaneng tsa molomo, lihlooho le tse nang le ente' me e amoheloa ke li-pharmacopoeia ho pota lefatše.
4. Litebello tsa 'maraka
Ka nts'etsopele e tsoelang pele ea indasteri ea meriana, litlhoko tsa boleng ba lithethefatsi le polokeho le tsona lia eketseha. Ka lebaka la thepa ea eona e ikhethang ea 'mele le lik'hemik'hale le polokeho e ntle, HPMC e na le tebello e pharaletseng ea ts'ebeliso litokisetsong tse ncha tsa lithethefatsi. Haholo-holo litabeng tsa litokisetso tsa tokollo e laoloang le e tsitsitseng, lithethefatsi tsa likokoana-hloko le meriana bakeng sa batho ba khethehileng (joaloka limela), tlhokahalo ea HPMC e tla tsoela pele ho hōla.
E le setsi sa meriana se sebetsang ka bongata, pharmaceutical grade hydroxypropyl methylcellulose e phethile karolo ea bohlokoa indastering ea meriana 'me e tla tsoela pele ho sebelisoa le ho ntlafatsoa haholo nakong e tlang.
Nako ea poso: Aug-06-2024