Lisebelisoa tsa Meriana Cellulose Ether

Natural cellulose ether ke lentsoe le akaretsang bakeng sa letoto lalihlahisoa tsa cellulosee hlahisoang ke karabelo ea alkali cellulose le etherifying agent tlasa maemo a itseng. Ke sehlahisoa seo lihlopha tsa hydroxyl ho cellulose macromolecules li nkeloang sebaka ke lihlopha tsa ether. Li-cellulose ethers li sebelisoa haholo masimong a petroleum, thepa ea kaho, liaparo, lijo, meriana le lik’hemik’hale tsa letsatsi le letsatsi. Likarolong tse fapaneng, lihlahisoa tsa boleng ba meriana ha e le hantle li bohareng le bo phahameng ba indasteri, ka boleng bo phahameng bo ekelitsoeng. Ka lebaka la litlhoko tse thata tsa boleng, tlhahiso ea ether ea cellulose ether ea sehlopha sa meriana le eona e batla e le thata. Ho ka boleloa hore boleng ba lihlahisoa tsa boleng ba meriana bo ka emela matla a tekheniki a lik'hamphani tsa cellulose ether. Cellulose ether e atisa ho eketsoa e le blocker, matrix material and thickener ho etsa matlapa a matrix a sa khaotseng, lisebelisoa tsa ho roala ka mpeng, lisebelisoa tsa ho roala tse sa khaotseng tsa microcapsule, lisebelisoa tsa filimi ea lithethefatsi tse sa khaotseng, joalo-joalo.

Sodium carboxymethyl cellulose:

Carboxymethyl cellulose sodium (CMC-Na) ke mofuta oa cellulose ether o nang le tlhahiso le tšebeliso e kholo ka ho fetisisa lapeng le kantle ho naha. Ke ionic cellulose ether e entsoeng ka k'hothone le patsi ka alkalization le etherification ka chloroacetic acid. CMC-Na ke motsoako o sebelisoang hangata oa meriana. Hangata e sebelisoa e le setlamo bakeng sa litokisetso tse tiileng, sekontiri se teteaneng, sekontiri se teteaneng, le se emisang ho lokisoa ha metsi. E ka boela ea sebelisoa e le matrix a qhibilihang ka metsi le thepa ea ho etsa filimi. Hangata e sebelisoa e le thepa ea filimi ea lithethefatsi e sa khaotseng le letlapa la matrix le tsoelang pele litokisetsong tse tsitsitseng (tse laoloang).

Ntle le sodium carboxymethylcellulose joalo ka mothusi oa meriana, croscarmellose sodium e ka sebelisoa hape joalo ka mothusi oa meriana. Croscarmellose sodium (CCMC-Na) ke sehlahisoa se ke keng sa qhibiliha sa carboxymethylcellulose se sebetsanang le motsoako oa crosslinking ka mocheso o itseng (40-80 ° C) tlas'a ketso ea inorganic acid catalyst le ho hloekisoa. Joalo ka li-crosslinking, propylene glycol, succinic anhydride, maleic anhydride le adipic anhydride e ka sebelisoa. Croscarmellose sodium e sebelisoa e le disintegrant bakeng sa matlapa, li-capsules le granules litokisetsong tsa molomo. E itšetlehile ka liphello tsa capillary le ho ruruha hore e qhalane. E na le compressibility e ntle le matla a matla a ho arohana. Liphuputso li bontšitse hore tekanyo ea ho ruruha ha sodium ea croscarmellose ka metsing e kholo ho feta ea li-disintegrants tse tloaelehileng tse kang carmellose sodium le hydrated microcrystalline cellulose.

Methylcellulose:

Methyl cellulose (MC) ke selulose e le 'ngoe e seng ea ionic e entsoeng ka k'hothone le patsi ka alkalization le methyl chloride etherification. Methylcellulose e na le ho qhibiliha ha metsi ka tsela e babatsehang 'me e tsitsitse ka mefuta ea pH2.0 ~ 13.0. E sebelisoa haholo ho li-excipients tsa meriana, 'me e sebelisoa ka matlapa a sublingual, liente tsa intramuscular, litokisetso tsa ophthalmic, li-capsules tsa molomo, li-suspension tsa molomo, matlapa a molomo le litokisetso tsa lihlooho. Ntle le moo, litokisetsong tse sa khaotseng tsa tokollo, MC e ka sebelisoa e le litokisetso tsa hydrophilic gel matrix, lisebelisoa tsa ho roala ka gastric-solluble, lisebelisoa tsa ho roala tse sa khaotseng tsa microcapsule, lisebelisoa tsa filimi tse lokollotsoeng ka nako e telele, jj.

Hydroxypropyl methyl cellulose:

Hydroxypropyl methylcellulose (HPMC) ke selulose e seng ionic e tsoakiloeng ka k'hothone le patsi ka alkalization, propylene oxide le methyl chloride etherification. Ha e na monko, ha e latsoehe, ha e chefo, e qhibiliha ka metsing a batang 'me e kenngoa metsing a chesang. Hydroxypropyl methylcellulose ke mofuta oa cellulose o tsoakiloeng oa ether eo tlhahiso, litekanyetso le boleng ba tsona li ntseng li eketseha ka potlako Chaena lilemong tse 15 tse fetileng. Hape ke e 'ngoe ea lisebelisoa tse sebelisoang ka ho fetisisa tsa meriana lapeng le linaheng tse ling. lilemo tsa histori. Hajoale, ts'ebeliso ea HPMC e bonts'oa haholo likarolo tse hlano tse latelang:

E 'ngoe e tšoana le se tlamang le ho arohana. Joalo ka setlamo, HPMC e ka etsa hore sethethefatsi se be bonolo ho koloba, 'me se ka atoloha ka makhetlo a makholo ka mor'a ho monya metsi, kahoo se ka ntlafatsa haholo sekhahla sa ho qhibiliha kapa sekhahla sa ho lokolloa ha letlapa. HPMC e na le viscosity e matla, e ka ntlafatsang viscosity ea likaroloana le ho ntlafatsa ho hatelloa ha thepa e tala ka sebopeho se crisp kapa brittle. HPMC e nang le viscosity e tlase e ka sebelisoa e le binder le disintegrant, 'me ba nang le viscosity e phahameng ba ka sebelisoa feela e le binder.

Ea bobeli ke e le mokhoa o tsitsitseng le o laoloang oa tokollo bakeng sa litokisetso tsa molomo. HPMC ke sesebelisoa sa hydrogel matrix se sebelisoang hangata litokisetsong tsa tokollo e tsitsitseng. Low-viscosity grade (5-50mPa·s) HPMC e ka sebelisoa e le binder, viscosifier le suspending agent, le high-viscosity grade (4000-100000mPa·s) HPMC e ka sebelisoa ho lokisa lintho tse tsoakiloeng Setsi sa Thibelo bakeng sa capsules, hydrogel matrix. matlapa a ho lokolloa ha nako e telele. HPMC e qhibiliha ka har'a mokelikeli oa ka mpeng, e na le melemo ea ho hatelloa hantle, metsi a matle, bokhoni bo matla ba ho kenya lithethefatsi, le litšobotsi tsa ho lokolloa ha lithethefatsi tse sa angoeng ke PH. Ke thepa ea bohlokoa haholo e tsamaisang hydrophilic lits'ebetsong tsa ho lokisoa ha nako e telele 'me hangata e sebelisoa e le Hydrophilic gel matrix le lisebelisoa tsa ho roala bakeng sa litokisetso tsa tokollo e sa feleng, hammoho le lisebelisoa tse thusang bakeng sa litokisetso tse phaphametseng ka mpeng le litokisetso tsa lifilimi tsa lithethefatsi tse tsoelang pele.

Ea boraro ke e le moemeli oa ho roala filimi. HPMC e na le thepa e ntle ea ho etsa lifilimi. Filimi e entsoeng ke eona e tšoana, e pepenene ebile e thata, 'me ha ho bonolo ho khomarela nakong ea tlhahiso. Haholo-holo bakeng sa lithethefatsi tse bonolo ho monya mongobo le tse sa tsitsang, ho li sebelisa e le lera la ho itšehla thajana ho ka ntlafatsa haholo botsitso ba lithethefatsi le ho thibela Filimi e fetola 'mala. HPMC e na le litlhaloso tse fapaneng tsa viscosity. Haeba e khethiloe hantle, boleng le ponahalo ea matlapa a koahetsoeng a phahametse lisebelisoa tse ling. Khatiso e tloaelehileng ke 2% ho isa ho 10%.

Ea bone e tšoana le thepa ea capsule. Lilemong tsa morao tjena, ka ho qhoma khafetsa ha mafu a seoa a liphoofolo lefatšeng ka bophara, ha ho bapisoa le li-capsules tsa gelatin, li-capsules tsa meroho li fetohile tse ratoang haholo indastering ea meriana le ea lijo. Pfizer ea United States e atlehile ho ntša HPMC limela tsa tlhaho le ho lokisa li-capsules tsa meroho tsa VcapTM. Ha ho bapisoa le li-capsules tsa setso tsa gelatin, li-capsules tsa semela li na le melemo ea ho ikamahanya le maemo ka bophara, ha li na kotsi ea karabelo ea li-cross-link le botsitso bo phahameng. Sekhahla sa ho lokolloa ha lithethefatsi se batla se tsitsitse, 'me liphapang tsa batho ka bomong li nyane. Ka mor'a ho arohana 'meleng oa motho, ha e monye 'me e ka ntšoa Ntho e ntšoa' meleng. Mabapi le maemo a polokelo, ka mor'a liteko tse ngata, ha e fokotsehe tlas'a maemo a tlaase a mongobo, 'me thepa ea khetla ea capsule e ntse e tsitsitse tlas'a maemo a phahameng a mongobo,' me matšoao a li-capsules tsa semela ha a amehe tlas'a polokelo e feteletseng. maemo. Ka kutloisiso ea batho ea li-capsules tsa semela le phetoho ea maikutlo a meriana ea sechaba lapeng le kantle ho naha, tlhoko ea 'maraka ea li-capsules tsa semela e tla hola ka potlako.

Ea bohlano e tšoana le moemeli ea emisang. Tokiso ea mokelikeli oa mofuta oa suspension ke mofuta o sebelisoang hangata oa litekanyetso tsa bongaka, e leng mokhoa o fapaneng oa ho hasana oo ho oona litlhare tse tiileng tse sa keneng li qhalakantsoeng ka har'a mokelikeli oa ho hasana. Ho tsitsa ha tsamaiso ho etsa qeto ea boleng ba ho lokisetsa mokelikeli oa ho emisa. Tharollo ea colloidal ea HPMC e ka fokotsa tsitsipano e tiileng ea metsi a sefahleho, ea fokotsa matla a mahala a likaroloana tse tiileng, le ho tsitsisa sistimi ea phepelo e fapaneng. Ke moemeli ea khabane oa ho emisa. HPMC e sebelisoa e le motenya bakeng sa marotholi a mahlo, a nang le litaba tsa 0.45% ho isa ho 1.0%.

Hydroxypropyl Cellulose:

Hydroxypropyl cellulose (HPC) ke selulose e le 'ngoe e se nang ionic e entsoeng ka k'hothone le patsi ka alkalization le propylene oxide etherification. Hangata HPC e qhibiliha ka metsing a ka tlase ho 40 ° C le palo e kholo ea li-solvents tsa polar, 'me ts'ebetso ea eona e amana le litaba tsa sehlopha sa hydroxypropyl le tekanyo ea polymerization. HPC e ka tsamaisana le lithethefatsi tse fapaneng mme e na le inertia e ntle.

Low-substituted hydroxypropyl cellulose (L-HPC) e sebediswa haholo-holo e le disintegrant le binder. -HPC e ka ntlafatsa ho thatafala le ho khanya ha letlapa, hape e ka etsa hore letlapa le qhalane ka potlako, le ntlafatse boleng ba ka hare ba letlapa, 'me le ntlafatse phello ea phekolo.

Hydroxypropyl cellulose (H-HPC) e nkeloang sebaka haholo e ka sebelisoa e le setlamo sa matlapa, li-granules le li-granules tse ntle lefapheng la meriana. H-HPC e na le thepa e ntle haholo ea ho etsa lifilimi, 'me filimi e fumanoeng e thata ebile e le elastic, e ka bapisoang le li-plasticizers. Ts'ebetso ea filimi e ka ntlafatsoa ka ho eketsehileng ka ho kopanya le lisebelisoa tse ling tse thibelang mongobo, 'me hangata li sebelisoa e le thepa ea ho roala filimi bakeng sa matlapa. H-HPC e ka boela ea sebelisoa e le lisebelisoa tsa matrix ho lokisa matlapa a lokolloang ka nako e telele a matrix, li-pellets tse sa khaotseng le matlapa a mabeli a lokolloang ka nako e telele.

Hydroxyethyl cellulose

Hydroxyethyl cellulose (HEC) ke selulose se seng sa ether se seng sa ionic se entsoeng ka k'hothone le patsi ka alkalization le etherification ea ethylene oxide. Lefapheng la meriana, HEC e sebelisoa haholo-holo e le motenya, moemeli oa tšireletso oa colloidal, sekhomaretsi, dispersant, stabilizer, moemeli oa ho emisa, moemeli oa ho etsa filimi le lisebelisoa tse tsoelang pele, 'me e ka sebelisoa ho li-emulsions tsa lihlooho, mafura, marotholi a mahlo, Mokelikeli oa molomo, letlapa le tiileng, capsule le mefuta e meng ea litekanyetso. Hydroxyethyl cellulose e tlalehiloe ho US Pharmacopoeia/US National Formulary le European Pharmacopoeia.

Ethyl cellulose:

Ethyl cellulose (EC) ke e 'ngoe ea lintho tse sebelisoang haholo tse tsoang ho selulose e sa keneng ka metsing. EC ha e na chefo, e tsitsitse, ha e qhibilihe ka har'a metsi, asiti kapa alkaline tharollo, 'me e qhibiliha ka har'a metsoako ea tlhaho e kang ethanol le methanol. Sehlapi se tloahelehileng se sebelisoang ke toluene/ethanol joalo ka 4/1 (boima) bo tsoakiloeng. EC e na le ts'ebeliso e ngata ho litokisetso tsa tokollo ea nako e telele ea lithethefatsi, e sebelisoang haholo e le bajari, li-microcapsules, le lisebelisoa tsa ho roala lifilimi bakeng sa litokisetso tsa tokollo e tsoelang pele, joalo ka li-block blockers, likhomaretsi le lisebelisoa tsa ho roala lifilimi, tse sebelisoang e le filimi ea matrix ho itokisetsa. mefuta e fapa-fapaneng ea matlapa a tsitsitseng a matrix, a sebelisoang e le lisebelisoa tse tsoakiloeng ho lokisetsa litokisetso tsa ho lokolloa ka nako e telele, li-pellets tse tsoelang pele, 'me li sebelisoa e le lisebelisoa tse thusang tsa encapsulation ho lokisetsa li-microcapsules tse tsoelang pele; e ka boela ea sebelisoa haholo e le thepa ea thepa Bakeng sa ho lokisetsa li-dispersions tse tiileng; e sebelisoang haholo ho thekenoloji ea meriana e le ntho e etsang filimi le ho roala ho sireletsa, hammoho le binder le filler. E le tšireletso e sireletsang ea letlapa, e ka fokotsa kutloisiso ea letlapa ho mongobo le ho thibela lithethefatsi hore li se ke tsa angoa ke mongobo, ho senya le ho senyeha; e ka boela ea theha lera la gel le theoha butle, la microencapsulate polymer, 'me la etsa hore ho be le tokollo e tsitsitseng ea phello ea lithethefatsi.