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Etsa Gel ea Sanitizer ea Hand u sebelisa HPMC ho nkela Carbomer sebaka

Etsa Gel ea Sanitizer ea Hand u sebelisa HPMC ho nkela Carbomer sebaka

Jele ea sanitizer ea letsoho e fetohile ntho ea bohlokoa bophelong ba rona ba letsatsi le letsatsi, haholo nakong ea seoa sa COVID-19. Motsoako o sebetsang ka har'a gel ea sanitizer ea letsoho hangata ke joala, bo sebetsang ho bolaea libaktheria le livaerase matsohong. Leha ho le joalo, ho etsa sebopeho sa gel, ho hlokahala hore ho be le motsoako o teteaneng ho etsa hore ho be le mokhoa o tsitsitseng o kang oa gel. Carbomer ke ntho e sebelisoang hangata ka har'a li-gel tsa sanitizer, empa ho ka ba thata ho e fumana mme e bone ho nyoloha ha litheko ka lebaka la seoa sena. Sehloohong sena, re tla tšohla mokhoa oa ho etsa gel ea sanitizer ea letsoho ka Hydroxypropyl Methylcellulose (HPMC) e le sebaka sa carbomer.

Hydroxypropyl Methylcellulose (HPMC) ke motsoako oa selulose o nang le mefuta e mengata ea lisebelisoa, ho kenyeletsoa joalo ka sekontiri, se tlamang, le emulsifier. HPMC ke polymer e qhibilihang ka metsing e ka etsang hore e be motenya o entsoeng ka metsi, e leng se etsang hore e be mokhoa o mong o loketseng oa carbomer ka lijeli tsa letsoho tsa sanitizer. HPMC e boetse e fumaneha habonolo ebile e na le litšenyehelo tse ngata ho feta carbomer, e etsang hore e be khetho e ntle bakeng sa bahlahisi.

Ho etsa gel ea sanitizer ea letsoho u sebelisa HPMC, lisebelisoa le lisebelisoa tse latelang lia hlokahala:

Lisebelisoa:

  • joala ba isopropyl (kapa ethanol)
  • Hydrogen peroxide
  • Glycerin
  • Hydroxypropyl Methylcellulose (HPMC)
  • Metsi a hloekisitsoeng

Thepa:

  • Ho kopanya sekotlolo
  • Molamu o hlohlelletsang kapa motsoako oa motlakase
  • Ho lekanya linoelo le likhaba
  • pH metara
  • Setshelo sa ho boloka gel ea sanitizer ea letsoho

Mohato oa 1: Lekanya metsoako Lekanya metsoako e latelang:

  • Isopropyl joala (kapa ethanol): 75% ea molumo oa ho qetela
  • Hydrogen peroxide: 0.125% ea molumo oa ho qetela
  • Glycerin: 1% ea molumo oa ho qetela
  • HPMC: 0.5% ea molumo oa ho qetela
  • Metsi a hloekisitsoeng: molumo o setseng

Mohlala, haeba u batla ho etsa 100ml ea gel ea letsoho la sanitizer, u tla hloka ho metha:

  • Isopropyl joala (kapa ethanol): 75ml
  • Hydrogen peroxide: 0.125ml
  • Glycerin: 1 ml
  • HPMC: 0.5ml
  • Metsi a hloekisitsoeng: 23.375ml

Mohato oa 2: Kopanya Metsoako Kopanya joala ba isopropyl (kapa ethanol), hydrogen peroxide, le glycerin hammoho ka sekotlolo se kopanyang. Hlohlelletsa motsoako ho fihlela o kopantsoe hantle.

Mohato oa 3: Eketsa HPMC Butle-butle eketsa HPMC ho motsoako ha u ntse u susumetsa ka ho tsoelang pele. Ho bohlokoa ho eketsa HPMC butle ho qoba ho putlama. Tsoela pele ho hlohlelletsa ho fihlela HPMC e hasane ka ho feletseng 'me motsoako o le boreleli.

Mohato oa 4: Eketsa Metsi Eketsa metsi a silafalitsoeng ho motsoako ha o ntse o hlohlelletsa o sa khaotse. Tsoela pele ho susumetsa ho fihlela motsoako o kopantsoe hantle.

Mohato oa 5: Sheba pH Lekola pH ea motsoako o sebelisa pH meter. PH e lokela ho ba pakeng tsa 6.0 le 8.0. Haeba pH e le tlase haholo, eketsa palo e nyane ea sodium hydroxide (NaOH) ho fetola pH.

Mohato oa 6: Kopanya Hape Kopanya motsoako hape ho etsa bonnete ba hore metsoako eohle e kopane ka botlalo.

Mohato oa 7: Fetisetsa ka nkho Fetisetsa gel ea letsoho la sanitizer ka sejaneng bakeng sa polokelo.

Sephetho se hlahisoang ke gel ea sanitizer ea letsoho e lokela ho ba le boreleli, joalo ka gel, e leng bonolo ho e sebelisa matsohong. HPMC e sebetsa joalo ka motenya mme e etsa hore ho be le sebopeho se tsitsitseng sa gel, se ts'oanang le carbomer. Gel ea sanitizer ea letsoho e hlahisoang e lokela ho sebetsa hantle ho bolaee libaktheria le livaerase matsohong, joalo ka ligelse tsa letsoho tse fumanehang khoebong.

Production practices (GMP) ke sete ya ditataiso le melaomotheo e netefatsang boleng le polokeho ya dihlahiswa tsa meriana, ho kenyeletswa le gel ya letsoho la sanitizer. Litataiso tsena li akaretsa likarolo tse fapaneng tsa tšebetso ea tlhahiso, ho kenyeletsoa basebetsi, meaho, lisebelisoa, litokomane, tlhahiso, taolo ea boleng le kabo.

Ha o etsa gel ea sanitizer ea letsoho o sebelisa HPMC kapa ntho efe kapa efe e tenya, ho bohlokoa ho latela litataiso tsa GMP ho netefatsa boleng le polokeho ea sehlahisoa. Litaelo tse ling tsa bohlokoa tsa GMP tse lokelang ho lateloa ha ho etsoa gel ea sanitizer ea letsoho li kenyelletsa:

  1. Basebeletsi: Basebetsi bohle ba amehang tšebetsong ea tlhahiso ba lokela ho koetlisoa ka nepo le ho tšoaneleha bakeng sa mesebetsi ea bona. Hape ba lokela ho hlokomela litataiso tsa GMP mme ba li latele ka tieo.
  2. Sebaka: Setsi sa tlhahiso se lokela ho hloeka, se hlokomeloe hantle, 'me se etsetsoe ho thibela tšoaetso. Setsi se lokela ho ba le moea o loketseng le mabone, 'me lisebelisoa tsohle li lokela ho lekanngoa hantle le ho tiisoa.
  3. Thepa: Lisebelisoa tsohle tse sebelisoang ha ho etsoa tlhahiso li lokela ho hloekisoa khafetsa le ho hlokomeloa ho thibela tšilafalo. Thepa e boetse e lokela ho netefatsoa ho etsa bonnete ba hore e sebetsa ka nepo le ho hlahisa liphetho tse ts'oanang.
  4. Litokomane: Mekhoa eohle ea tlhahiso e lokela ho ngoloa ka nepo, ho kenyeletsoa litlaleho tsa batch, mekhoa e tloaelehileng ea ts'ebetso (SOPs), le litlaleho tsa taolo ea boleng. Litokomane li lokela ho ba tse phethahetseng le tse nepahetseng ho netefatsa ts'ebetso le boikarabello.
  5. Tlhahiso: Ts'ebetso ea tlhahiso e lokela ho latela mokhoa o hlalositsoeng le o netefalitsoeng o netefatsang boleng bo tsitsitseng le bohloeki ba sehlahisoa. Lisebelisoa tsohle tse sebelisoang ts'ebetsong ea tlhahiso li lokela ho tsejoa ka nepo, ho netefatsoe le ho bolokoa.
  6. Taolo ea boleng: Mehato ea taolo ea boleng e lokela ho ba teng ho netefatsa hore sehlahisoa sa ho qetela se kopana le litlhaloso tse hlokahalang. Taolo ea boleng e tlameha ho kenyelletsa tlhahlobo ea boitsebahatso, bohloeki, matla, le lintlha tse ling tse amehang.
  7. Kabo: Sehlahisoa se felileng se lokela ho pakoa hantle, se ngoloe, 'me se bolokoe ho thibela tšilafalo le ho boloka botšepehi ba sona. Ts'ebetso ea kabo e tlameha ho ngoloa hantle, 'me thomello eohle e lokela ho lateloa le ho behoa leihlo ka nepo.

Ka ho latela litataiso tsena tsa GMP, bahlahisi ba ka etsa bonnete ba hore lihlahisoa tsa bona tsa li-gel sanitizer ke tsa boleng bo holimo ebile li bolokehile hore li ka sebelisoa. Litataiso tsena li boetse li thusa ho netefatsa botsitso le ts'epahalo ts'ebetsong ea tlhahiso, e leng bohlokoa ho fihlela tlhoko e ntseng e hola ea lijeli tsa sanitizer nakong ea seoa sa COVID-19.

Qetellong, Hydroxypropyl Methylcellulose (HPMC) e ka sebelisoa e le phetisetso ea carbomer e entsoeng ka letsoho la sanitizer gel. HPMC ke mokhoa o sa sebetseng hantle le o fumanehang habonolo o ka fanang ka thepa e ts'oanang e tenya ho carbomer. Ha o etsa gel ea sanitizer ea letsoho o sebelisa HPMC, ho bohlokoa ho latela litataiso tsa GMP ho netefatsa boleng le polokeho ea sehlahisoa. Ka ho latela litataiso tsena, bahlahisi ba ka hlahisa gel ea sanitizer ea letsoho e atlehang ho bolaea libaktheria le livaerase matsohong, ha ba ntse ba netefatsa polokeho ea mosebelisi oa ho qetela.


Nako ea poso: Mar-18-2023
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