Hydroxypropylmethylcellulose (HPMC) ke motsoako o feto-fetohang le o feto-fetohang o nang le ts'ebeliso ho pholletsa le liindasteri tse fapaneng. Ho utloisisa moelelo oa eona, motho o tlameha ho hlahlobisisa metsoako ea eona, mekhoa ea tlhahiso le tšimoloho.
Lintho tse ka sehloohong tsa HPMC:
HPMC ke semi-synthetic polymer e nkiloeng ho cellulose, polysaccharide ea tlhaho e fumanehang maboteng a lisele tsa semela. Mohloli o ka sehloohong oa selulose ke makhasi a lehong kapa fiber ea k'hothone. Tšimoloho ea HPMC e kenyelletsa ho fetola selulose ka letoto la karabelo ea lik'hemik'hale ho e etsa e nkiloeng ho selulose.
Likarolo tsa maiketsetso tsa tlhahiso ea HPMC:
Mokhoa oa Etherification:
Tlhahiso ea HPMC e kenyelletsa etherification ea cellulose ka propylene oxide le methyl chloride.
Nakong ea ts'ebetso ena, lihlopha tsa hydroxypropyl le methyl li kenngoa mokokotlong oa cellulose, ho etsa HPMC.
Phetoho ea lik'hemik'hale:
Liphetoho tsa lik'hemik'hale tse hlahisitsoeng nakong ea motsoako li etsa hore HPMC e khethoe e le motsoako oa semi-synthetic.
Degree of substitution (DS) e bolela palo e tloaelehileng ea lihlopha tsa hydroxypropyl le methyl ka yuniti ea tsoekere ka har'a ketane ea cellulose. Boleng bona ba DS bo ka fetoloa nakong ea ts'ebetso ea tlhahiso ho fumana HPMC e nang le thepa e ikhethileng.
Tlhahiso ea indasteri:
HPMC e hlahisoa indastering ka tekanyo e kholo ke lik'hamphani tse 'maloa tse sebelisang liphetoho tsa lik'hemik'hale tse laoloang.
Ts'ebetso ea tlhahiso e kenyelletsa maemo a nepahetseng ho fihlela thepa e lakatsehang le ts'ebetso ea sehlahisoa sa ho qetela.
Mehloli ea tlhaho ea HPMC:
Cellulose e le mohloli oa tlhaho:
Cellulose ke thepa ea mantlha ea HPMC mme e ngata ka tlhaho.
Limela, haholo-holo lehong le k'hothone, li na le mehloli e mengata ea cellulose. Ho ntšoa ha cellulose mehloling ena ea tlhaho ho qala ts'ebetso ea tlhahiso ea HPMC.
Biodegradability:
HPMC e khona ho senyeha, e leng thepa ea lisebelisoa tse ngata tsa tlhaho.
Ho ba teng ha selulose ea tlhaho ho HPMC ho kenya letsoho ho thepa ea eona e ka senyehang, ho e etsa hore e boloke tikoloho lits'ebetsong tse itseng.
Lisebelisoa tsa HPMC:
lithethefatsi:
HPMC e sebelisoa haholo indastering ea meriana e le lisebelisoa tsa ho roala, li-binders le li-matrices tse sa khaotseng ho etsoa ka matlapa. Thepa ea eona ea biocompatibility le thepa ea tokollo e laoloang e e etsa khetho ea pele bakeng sa litsamaiso tsa phepelo ea lithethefatsi.
Indasteri ea kaho:
Ha ho hahoa, HPMC e sebelisoa e le sesebelisoa sa ho boloka metsi, se teteaneng, le ho beha taolo ea nako ka thepa e thehiloeng ho samente. Karolo ea eona ea ho ntlafatsa ts'ebetso le ho khomarela lirafshoa le li-plaster ke ea bohlokoa.
indasteri ea lijo:
HPMC e sebelisoa e le setei se teteaneng le se etsang gelling indastering ea lijo.
Hangata e sebelisoa lihlahisoa tsa lijo tse kang li-sauces, sopho le thepa e halikiloeng.
cosmetic:
Ho litlolo, HPMC e fumanoa lihlahisoa tse fapaneng tse kenyelletsang litlolo, litlolo le li-gel, tse sebetsang e le li-thickeners, stabilizers le emulsifiers.
Lisebelisoa tsa indasteri:
Ho feto-fetoha ha maemo ha HPMC ho fetela lits'ebetsong tse fapaneng tsa indasteri, ho kenyeletsoa ho etsa pente, likhomaretsi le ts'ebetso ea masela.
Boemo ba taolo:
Boemo ba GRAS:
United States, HPMC ka kakaretso e amoheloa e le e bolokehileng (GRAS) bakeng sa lits'ebetso tse itseng tsa lijo ke US Food and Drug Administration (FDA).
Litekanyetso tsa lithethefatsi:
HPMC e sebelisoang lihlahisoa tsa meriana e tlameha ho lumellana le litekanyetso tsa meriana tse kang United States Pharmacopeia (USP) le European Pharmacopoeia (Ph. Eur.).
ha re phethela:
Ka kakaretso, hydroxypropyl methylcellulose (HPMC) ke semi-synthetic polymer e nkiloeng ho selulose ea tlhaho ka mokhoa o laoloang oa phetoho ea lik'hemik'hale. Leha e bile le phetoho e kholo ea maiketsetso, tšimoloho ea eona e ho lisebelisoa tsa tlhaho joalo ka makhasi a patsi le k'hothone. Thepa e ikhethang ea HPMC e etsa hore e be motsoako oa bohlokoa o sebelisoang haholo ho tsa meriana, kaho, lijo, litlolo le liindasteri tse sa tšoaneng. Motsoako oa selulose ea tlhaho le liphetoho tsa maiketsetso li kenya letsoho ho feto-fetoheng ha eona, ho senyeha ha biolose le ho amoheloa ka molao mafapheng a fapaneng.
Nako ea poso: Dec-18-2023