Hydroxypropyl methylcellulose (HPMC) ke polima e feto-fetohang e sebelisoang liindastering tse fapaneng ka lebaka la thepa ea eona e ikhethang. Le ha e ka sebelisoa ho etsa li-hydrogel tlasa maemo a itseng, ha se hydrogel ka boeona.
1. Selelekela ho HPMC:
Hydroxypropyl methylcellulose (HPMC) ke semi-synthetic polymer e nkiloeng ho cellulose, polima ea tlhaho e fumanehang maboteng a lisele tsa limela. E entsoe ka ho phekola selulose ka alkali ebe e e sebetsa ka propylene oxide le methyl chloride. Polymer e hlahisoang e bonts'a mefuta e mengata ea thepa e e etsang hore e be ea bohlokoa liindastering tse fapaneng, ho kenyeletsoa meriana, lijo, litlolo le kaho.
2. Thepa ea HPMC:
HPMC e na le lintho tse 'maloa tse molemo:
a. Ho qhibiliha ha Metsi:
HPMC e qhibiliha ka metsing, e etsa litharollo tsa viscous. Thepa ena e bohlokoa haholo litlhare, moo e ka sebelisetsoang ho theha li-suspension, li-emulsions, le li-formation tsa lithethefatsi tse laoloang.
b. Bokhoni ba ho Etsa Lifilimi:
HPMC e ka etsa lifilimi tse feto-fetohang le tse pepeneneng ha li tsoa ho litharollo tsa eona tse nang le metsi. Lifilimi tsena li fumana ts'ebetso ka har'a likoahelo tsa matlapa, li-capsules le lifilimi tsa molomo.
c. Mofetoleli oa Rheology:
HPMC e sebetsa joalo ka motenya le mofetoleli oa rheology litharollong tse nang le metsi. Viscosity ea eona e ka hlophisoa ka ho lokisa lintlha tse kang boima ba limolek'hule le tekanyo ea ho fetola.
d. Biocompatibility:
HPMC ke biocompatible le ha e chefo, e etsa hore e loketse ho sebelisoa ka meriana, litlolo, le lihlahisoa tsa lijo.
3. Likopo tsa HPMC:
HPMC e fumana lits'ebetso tse atileng ho liindasteri tse fapaneng:
a. Meriana:
Mekhatlong ea meriana, HPMC e sebelisoa e le se tlamella, se senyang, se koahelang filimi, le matrix a tsoelang pele a lokolloang. E matlafatsa botšepehi ba letlapa, e laola kinetics ea ho lokolloa ha lithethefatsi, 'me e ntlafatsa ho latela melao ea mokuli.
b. Indasteri ea Lijo:
Indastering ea lijo, HPMC e sebelisoa e le setei, emulsifier, stabilizer le gelling agent. E thusa ho etsa hore lijo li be bonolo, li shebahale hantle le hore li tsitsitse lijong tse kang li-sauces, li-dressings le li-dessert.
c. Litlolo:
HPMC e sebelisoa ho litlolo le lihlahisoa tsa tlhokomelo ea motho e le ntho e teteaneng, e emisang, ea pele ea filimi, le emulsifier. E fana ka thepa ea rheological e lakatsehang ho litlolo, litlolo le li-gel ha e ntse e ntlafatsa botsitso le litšobotsi tsa bona tsa kutlo.
d. Kaho:
Indastering ea kaho, HPMC e sebelisoa ka thepa ea samente e le ntho e bolokang metsi, e matlafatsang ts'ebetso, le ntho e tiisang matla. E ntlafatsa litšobotsi tsa seretse le samente, joalo ka ho khomarela, momahano, le ho hanyetsa ho sag.
4. Sebopeho sa Hydrogel le HPMC:
Le hoja HPMC ka boeona e se hydrogel, e ka kenya letsoho ho thehoa ha hydrogel tlas'a maemo a loketseng. Hydrogel ke marang-rang a liketane tsa polymer tse khonang ho monya le ho boloka metsi a mangata. Ho theoa ha li-hydrogel tsa HPMC hangata ho kenyelletsa ho hokahanya liketane tsa polymer ho theha marang-rang a mahlakore a mararo a khonang ho monya metsi.
a. Crosslinking Agents:
Lisebelisoa tse kopanyang tse kang glutaraldehyde, genipin, kapa mekhoa ea 'mele joalo ka li-cycles tsa leqhoa li ka sebelisoa ho tšela liketane tsa HPMC. Ho kopanya hona ho fella ka ho thehoa ha marang-rang a hydrogel ka har'a matrix a HPMC.
b. Boitšoaro ba ho Ruruha:
Thepa ea hydrogel ea HPMC e ka hlophisoa ka ho lokisa lintlha tse kang tekanyo ea ho fetola, boima ba limolek'hule, le boima ba li-crosslinking. Likhato tse phahameng tsa ho nka sebaka le boima ba limolek'hule ka kakaretso li lebisa ho eketseha ha matla a ho ruruha ha hydrogel.
c. Lisebelisoa tsa HPMC Hydrogels:
Li-hydrogel tsa HPMC li fumana ts'ebeliso ea phepelo ea lithethefatsi, pholiso ea maqeba, boenjineri ba lisele, le lilense tsa ho ikopanya. Li-biocompatibility tsa tsona, thepa e ka sebelisoang, le bokhoni ba ho boloka metsi li etsa hore li tšoanelehe bakeng sa lits'ebetso tse fapaneng tsa biomedical.
HPMC ke polymer e feto-fetohang e nang le lisebelisoa tse fapaneng ho pholletsa le meriana, lijo, litlolo le liindasteri tsa kaho. Leha e se hydrogel ka tlhaho, e ka nka karolo ho thehoeng ha hydrogel ka ho hokahanya liketane tsa eona tsa polymer. Li-hydrogel tsa HPMC tse hlahisoang li bonts'a thepa e kang ho monya metsi le ho bolokoa, ho li etsa tsa bohlokoa lits'ebetsong tsa biomedical. Ha lipatlisiso li ntse li tsoela pele ho hlahloba ts'ebeliso le liqapi tse ncha tsa HPMC, bohlokoa ba eona liindastering tse fapaneng bo lebelletsoe ho hola le ho feta.
Nako ea poso: Mar-06-2024