HydroxypropypropyLese (HPMC)Na 'marabele oa polymer ea nang le metsi a qholotsang metsi a sebelisoa haholo masimong a kaho, meriana ea meriana, meriana, litlolo, lijo le indasteri ea lijo le peterole. E thehiloe holima semela sa tlhaho cellulose ea tlhaho mme e fumanoa ka boitšoaro ba lik'hemik'hale. E na le solelo e ntle ea metsi, e etsang thepa ea ho ikamahanya le ho ikamahanya le ho tšoarela. Tlhahiso ea indasteri ea kimacell®hpm e kenyelletsa karabelo ea ts'ebetso ea cellulose. Boitšoaro bo tloaelehileng ba ho fetola lintho tse amanang le ho boloka litlolo le hydrompypropylation.
1. Lisebelisoa tse tala le tse qalang tsa hpmc
Sesebelisoa sa Raw se Roalose sa Forese: Tlhahiso ea HPMC e qala ka celluulo ea tlhaho. Mehloli e tloaelehileng e kenyelletsa likhoele tsa limela tse kang likhoele tsa lehong, k'hothone le hemp. Bakeng sa ho netefatsa tsoelo-pele e boreleli ea maikutlo a makatsang, hangata cellulose hangata e lokela ho itšireletsa ho tlosa litšila le ho eketsa tšebetso ea karabelo.
Mehato ea Pretreaty: Phatlalatso ea Cellulose ka kakaretso e kenyelletsa mehato e kang ho hlatsoa cellulo
2. Synthesis e ntse e sebetsa hpmc
Ts'ebetso ea Synthasis ea HPMC e kenyeletsoa maikutlong a ho betla le hydromplation, e ntseng e etsoa tlas'a maemo a alkaline. Ts'ebetso e ikhethileng ea tlhahiso e kenyelletsa mehato e latelang:
Ts'ebetso ea celluulose: E le ho etsa hore cellulose e be habonolo Mothating ona, kristale ea clloulose e fokotseha mme sebopeho se etsa sejo, se thusang ho feto-fetoha ha lik'hemik'hale.
Karabelo ea Methylation: Boitšoaro ba Methylation bo fetola molek'hulese ea cellulose ka ho kenyelletsa sehlopha sa methyl (-ch₃). Hangata li-agens tse tloaelehileng li sebelisoa ke methyl chloride (Ch,000l chloride (Ch,000l chloride (Ch,000l) kapa chloroform (Chl .form). Boteng ba sodium hydroxide, moemeli oa methylating a qotsa a mang a lihlopha tse ling tsa hydrouddle (-ch), ka tsela eo u etsa litlolo tsa tšepe.
Boitšoaro ba Hydroxypropytion: Kamora hore ho be le methyhala ho phetheloa, propylene (Po) hangata e sebelisoa ke sehlopha sa hydroxypropyl (-ch₂ch (Oh) ch₃). Karabelo e etsoa tlasa maemo a alkaline. Boitšoaro ba hydroxypropytion bo nka sebaka sa mefuta e meng ea methapo ea thekeng ea celdroulo ka lihlopha tsa hydroxypropy, ka hona ba theha hpmc.
Ts'ebetso ea karabelo: Nakong ea ts'ebetso eohle, mocheso le karoloana ea li-hydroxyproxy®hpm e fihlella litlhoko tsa sehlahisoa. Ka kakaretso, thempereichara ea karabelo e laoloa lipakeng tsa 30 le 80. Nako ea ho arabela ka lihora tse ngata ho tloha lihora tse ngata ho isa ho lihora tse fetang tse leshome.
Ho se nke lehlakore le ho hloekisoa: Kamora hore karabelo e phetheloe, sehlahisoa sa acid, sa hydrocloric ho khelosa lintho tse ngata tse feteletseng. Mehato ea tlhoekiso e kenyelletsa ho hlatsoa, ho otla, ho omisa le lits'ebetso tse ling ho tlosa lisebelisoa tse sa amaneng, li-solvents le lihlahisoa tse ling.
3. Sehlahisoa se omella le ho paka
Ho omella: HPMC e hloekisitsoeng hangata e teng ka mokhoa oa phofo ea metsi, 'me mongobo o tlameha ho tlosoa ke ho omella le ho omella le ho omisa le mekhoa e meng le mekhoa e meng. Sehlahisoa se omisitsoeng se lokela ho boloka semelo se tlase, hangata se laoloa ka tlase ho 5%, ho thibela sehlahisoa ho tsoa ho khomarela le ka boomo.
Ho paka: HPMC e omisitsoeng e kenngoa sebopeho sa phofo, 'me ts'ebetso ea pakete e hloka kalafo ea botsofaling. Hangata e kenella ka mekotleng ea polyethylene, mekotla ea pampiri kapa mekotla ea likarolo tsa lipalangoang tse bonolo.
4. Matla a boleng le litekanyetso tsa sehlahisoa
Boemong ba tlhahiso ea hpmc, taolo ea boleng bo tiileng ea bohlokoa e bohlokoa. Boleng ba HPMC bo itšetlehile feela ka boleng ba thepa e tala, empa hape le ka lintlha tse kang maemo a ho sebelisa le lits'ebetso tsa kamora ho sebetsa le lits'ebetso tsa kamora ho sebetsa le lits'ebetso tsa kamora ho sebetsa. Hangata baetsi ba lihlahisoa ba khanna tlhahlobo ea boleng ba boleng ho latela litekanyetso tsa machabeng le tsa tikoloho. Matšoao a tloaelehileng a boleng a kenyeletsa:
Fuubility: HPMC e lokela ho ba le liahelo tse ntle tsa metsi, le sekhahla sa disfor le li-dissolution li hloka ho fihlela litlhoko tse boletsoeng.
Viscosity: Ke pono ea HPMC ka kotloloho e ama litlamorao tsa eona, 'me lihlahisoa tse fapaneng li na le litlhoko tse fapaneng tsa pono. Mekhoa e tloaelehileng ea tlhahlobo ea tlhahlobo ea liteko e kenyelletsa mokhoa oa lipampitšana oa Vrookfield.
Bohloeki le litlolo: Sekhahla: Liteko tsa HPMC li lokela ho laoloa ka har'a mofuta o boletsoeng ho netefatsa bohloeki bo phahameng ea sehlahisoa.
Boholo ba tsona: Ho latela litlhoko tsa masimo a fapaneng a kopo, boholo ba HPMC bo ka fapana, 'me ho ka ba le phofo ea granilar kapa lihlahisoa tsa granilar li tla ba le phofo e fapaneng ea kopo.
5. Litulo tsa kopo ea HPMC
HPMC e sebelisoa haholo indastering e ngata 'me e na le boleng ba bohlokoa khoebong.
Indasteri ea kaho: HPMC e sebelisoa haholo joalo ka litlhahiso tsa metsi le metsi le thepa ea seretse sa seretse sa kaho le bolokolohi ba metsi.
Liipori tsa pharmacecticalical: HPMC e na le likopo tsa bohlokoa tšimong ea meriana e le li-capsule likhetla, mabelo a lithethefatsi a ho lokolla le ho lokolla thepa ea litheko.
Indasteri ea lijo: lijong, hpmc e sebelisoa e le bolo ea thipa, e leng Emulfifier, e joalo.
Indasteri ea litlolo: HPMC e sebelisoa e le moemeli ea etsang thipa le lifilimi ho litlolo, 'me e sebelisoa ho tsoa ho tsoa ho lihlahisoa tsa lihlahisoa tse joalo ka meroho le litlolo.
Masimo a mang: Kimacell®hpmC e boetse e sebelisoa haholo indastering e kang ea Petrole, mantsoe, pampiri, pampiri.
Tlhahiso ea indasteri eaHpmce fetoloa con celluuloulose ea tlholeho e nang le moea o tukang ka metsi ka thepa ea multiSunctol ka tatellano ea liphetoho tsa lik'hemik'hale. Ka ho laola maemo a mokhoa o nepahetseng le lits'ebetso tsa kalafo ea poso, HPMC litlhokahalo tse fapaneng tsa kopo li ka fumanoa. Ka kopo e atileng ea HPMC, lipatlisiso tse eketsehileng tsa lipatlisiso le tsa theknoloji le mahlale a mahlale a tla tsoela pele ho khothaletsa ntlafatso ea ts'ebetso ea eona le boleng ba sehlahisoa.
Nako ea ho romella: Jan-27-2025