Hypromellose Excipient | Lisebelisoa, Bafani, le Litlhaloso

Hypromellose, eo hape e tsejoang e le hydroxypropyl methylcellulose (HPMC), ke sesebelisoa se sebetsang ka mokhoa o fapaneng se sebelisoang hangata ho etsa meriana, litlolo, lihlahisoa tsa lijo le lits'ebetso tse fapaneng tsa indasteri. Mona ke kakaretso ea hypromellose excipient, ho kenyelletsa le ts'ebeliso ea eona, barekisi le litlhaloso:

Lisebelisoa:

1. Litlhare: Hypromellose e sebelisoa haholo e le moemeli oa meriana mefuteng ea litekanyetso tse tiileng tsa molomo joalo ka matlapa, li-capsules le granules. E sebetsa joalo ka setlamo se kopanyang, se senyang, se teteaneng le sa ho etsa lifilimi, se kenyang letsoho molemong oa 'mele le oa mochini oa mefuta ea litekanyetso.
2. Litharollo tsa Ophthalmic: Litharollong tsa mahlo, hypromellose e sebelisoa e le setlolo le se ntlafatsang ponahalo ea mahlo marotholing a mahlo le litlolo ho ntlafatsa ocular hydration le ho lelefatsa nako ea ho lula ha lithethefatsi sebakeng sa mahlo.
3. Litokisetso tsa lihlooho: Hypromellose e kenyelelitsoe mefuteng ea lihlooho tse kang litlolo, li-gel, le litlolo e le ntho e matlafatsang, emulsifier, le stabilizer ho ntlafatsa ts'ebetso ea sehlahisoa, ho ata le ho phela ha shelf.
4. Mekhoa ea ho Lokolla e Laoloang: Hypromellose e sebelisoa ka mokhoa o laoloang-ho lokolloa le ho lokolloa ka mokhoa o tsitsitseng ho fetola kinetics ea ho lokolloa ha lithethefatsi, ho fana ka litlaleho tse atolositsoeng tsa ho lokolloa ha lithethefatsi le ho ntlafatsa ho latela melao ea mokuli.
5. Lihlahisoa tsa Lijo: Indastering ea lijo, hypromellose e sebelisoa e le ntho e matlafatsang, e tsitsitseng, le emulsifier lihlahisoa tse fapa-fapaneng tsa lijo, ho akarelletsa le li-sauces, li-dressings, li-dessert le lintho tse halikiloeng.
6. Litlolo: Hypromellose e kenyelelitsoe ho litlolo tsa litlolo tse kang litlolo, litlolo, le lihlahisoa tsa litlolo e le moemeli o teteaneng, oa pele oa filimi, le moemeli oa ho boloka mongobo ho ntlafatsa sebopeho sa sehlahisoa le ts'ebetso.

Bafani:

Hypromellose excipient e fumaneha ho tsoa ho barekisi ba bangata lefatšeng ka bophara. Barekisi le bahlahisi ba bang ba hlahelletseng ba kenyelletsa:

1. Ashland Global Holdings Inc.: Ashland e fana ka mefuta e mengata ea lihlahisoa tsa hypromellose tlas'a mabitso a marang-rang Benecel® le Aqualon™, e sebetsanang le likopo tsa meriana le tsa tlhokomelo ea botho.
2. Kima Chemical Co.,Ltd:Kima Chemical e fana ka lihlahisoa tse thehiloeng ho hypromellose tlasa lebitso la lebitsoKIMACELL, tse sebelisoang litlhare, lijong le lits'ebetsong tsa indasteri.
3. Shin-Etsu Chemical Co., Ltd.: Shin-Etsu e etsa lihlahisoa tse thehiloeng ho hypromellose tlasa lebitso la brand Pharmacoat ™, e sebeletsang liindasteri tsa meriana, lijo le litlolo.
4. Colorcon: Colourcon e fana ka li-excipients tsa meriana tse thehiloeng ho hypromellose tlas'a lebitso la Opadry®, e etselitsoeng ho roala filimi ea letlapa le nts'etsopele ea tlhahiso.
5. JRS Pharma: JRS Pharma e fana ka lihlahisoa tse ngata tsa hypromellose tlas'a lebitso la Vivapur®, tse etselitsoeng ka ho khetheha bakeng sa lisebelisoa tsa meriana tse kang ho tlama letlapa, ho arohana, le ho lokolloa ho laoloang.

Litlhaloso:

Litlhaloso tsa hypromellose excipient li ka fapana ho latela ts'ebeliso ea eona e reriloeng le litlhoko tsa taolo. Litlhaloso tse tloaelehileng li kenyelletsa:

• Viscosity: Hypromellose e fumaneha ka limaraka tse fapaneng tsa viscosity, hangata ho tloha ho tlase ho isa ho viscosity e phahameng, ho fihlela litlhoko tse ikhethileng tsa ho bopa.
• Boholo ba Particle: Kabo ea boholo ba karolo e ka ama thepa ea phallo le compressibility ea phofo ea hypromellose, e amang ts'ebetso ea tlhahiso ea letlapa.
• Mongobo: Likahare tsa mongobo ke parameter ea bohlokoa e ka amang botsitso le ts'ebetso ea metsoako e thehiloeng ho hypromellose.
• Bohloeki le Litšila: Litlhaloso tsa bohloeki, hammoho le meeli ea litšila tse kang litšepe tse boima, li-solvents tse setseng, le likokoana-hloko tsa likokoana-hloko, li netefatsa boleng le polokeho ea lihlahisoa tsa hypromellose bakeng sa tšebeliso ea meriana le lijo.
• Ho lumellana: Hypromellose e lokela ho lumellana le li-excipients tse ling le metsoako e sebetsang ha ho etsoa, ​​​​hammoho le mekhoa ea ho sebetsa le lisebelisoa tse sebelisoang tlhahisong.

Ha u batla hypromellose excipient, ho bohlokoa ho fumana litifikeiti tsa tlhahlobo (CoA) le litokomane tsa tumellano ho tsoa ho barekisi ho netefatsa hore sehlahisoa se kopana le lintlha tse hlokahalang le litekanyetso tsa taolo bakeng sa ts'ebeliso e reriloeng. Ho feta moo, tšebelisano 'moho le barekisi ba nang le litsebo le ho latela mekhoa e metle ea tlhahiso (GMP) ke tsa bohlokoa bakeng sa ho netefatsa boleng, ho tsitsana, le ho latela melao ea litlhahlobo tse thehiloeng ho hypromellose.