Hydroxypropylmethylcellulose (HPMC) ke motsoako o feto-fetohang o sebelisoang liindastering tse fapaneng tse kenyelletsang meriana, lijo, kaho le litlolo. Ho utloisisa sebopeho sa eona, sebopeho, thepa le lits'ebetso ho hloka boithuto bo tebileng ba sebopeho sa eona sa lik'hemik'hale le ts'ebetso ea ho kopanya.
tlhamo le sebopeho
Cellulose Backbone: HPMC e tsoa ho cellulose, polima ea tlhaho e fumanehang maboteng a lisele tsa semela. Cellulose e entsoe ka liketane tse telele tsa likarolo tsa tsoekere tse hokahantsoeng ka libond tsa β-1,4 tsa glycosidic.
Methylation: Methylcellulose ke selelekela sa HPMC mme e hlahisoa ka ho phekola selulose ka alkali le methyl chloride. Mokhoa ona o kenyelletsa ho nkela lihlopha tsa hydroxyl (-OH) sebakeng sa mokokotlo oa cellulose ka lihlopha tsa methyl (-CH3).
Hydroxypropylation: Ka mor'a methylation, hydroxypropylation e etsahala. Mohato ona, propylene oxide e sebetsana le methylated cellulose, e hlahisang lihlopha tsa hydroxypropyl (-OCH2CHOHCH3) mokokotlong oa cellulose.
Degree of Substitution (DS): Tekanyo ea ho nka sebaka e bolela palo e tloaelehileng ea lihlopha tsa hydroxypropyl le methyl ka yuniti ea tsoekere ka ketane ea cellulose. Paramethara ena e ama thepa ea HPMC, ho kenyelletsa le solubility ea eona, viscosity, le boitšoaro ba mocheso.
tlhaho
Kalafo ea alkaline: Likhoele tsa cellulose li qala ho phekoloa ka tharollo ea alkaline, hangata sodium hydroxide (NaOH), ho senya li-intermolecular hydrogen bond le ho eketsa phihlello ea lihlopha tsa cellulose hydroxyl.
Methylation: Cellulose e tšoaroang ka alkali e arajoa ka methyl chloride (CH3Cl) tlas'a maemo a laoloang, e leng se bakang ho nkeloa sebaka ha lihlopha tsa hydroxyl ka lihlopha tsa methyl.
Hydroxypropylation: Selulose ea methylated e tsoela pele ho sebetsana le propylene oxide (C3H6O) ka pel'a ntho e thusang joalo ka sodium hydroxide. Karabelo ena e hlahisa lihlopha tsa hydroxypropyl mokokotlong oa cellulose.
Neutralization le Hloekiso: Neutralization motsoako oa karabelo ho tlosa motheo ofe kapa ofe o feteletseng. Sehlahisoa se fumanoeng se etsa mehato ea tlhoekiso joalo ka ho sefa, ho hlatsoa le ho omisoa ho fumana sehlahisoa sa ho qetela sa HPMC.
sebopeho
Solubility: HPMC e qhibiliha ka metsing 'me e etsa tharollo e hlakileng, e hlakileng. Ho qhibiliha ho itšetlehile ka lintlha tse kang tekanyo ea ho fetola, boima ba molek'hule le mocheso.
Viscosity: Litharollo tsa HPMC li bonts'a boits'oaro ba pseudoplastic, ho bolelang hore viscosity ea bona e fokotseha ka sekhahla sa ho kuta. Viscosity e ka laoloa ka ho fetola maemo a kang DS, boima ba limolek'hule le mahloriso.
Tlhahiso ea Lifilimi: HPMC e etsa lifilimi tse feto-fetohang le tse pepeneneng ha li etsoa ho tsoa tharollong ea eona ea metsi. Lifilimi tsena li fumana lits'ebetso ho li-coatings, liphutheloana le litlhare.
Thermal Stability: HPMC e tsitsitse ka mocheso mocheso o itseng, ka holim'a moo ho senyeha ho hlahang. Ho tsitsa ha mocheso ho itšetlehile ka lintlha tse kang DS, boemo ba mongobo, le boteng ba li-additives.
Libaka tsa kopo
Meriana ea Meriana: HPMC e sebelisoa haholo mekhoeng ea meriana e le li-thickeners, li-binders, li-agents tsa ho etsa lifilimi le li-matrices tse tsoelang pele. E ntlafatsa ho arohana ha letlapa, ho qhibiliha le bioavailability.
Lijo: indastering ea lijo, HPMC e sebelisoa e le setenya, se tsitsitseng, se emulsifier le se tlatsang lihlahisoa tse kang lisoso, liaparo, thepa e halikiloeng le lihlahisoa tsa lebese.
Kaho: HPMC e eketsoa liretseng tse thehiloeng ho samente, li-stucco le likhomaretsi tsa lithaele ho ntlafatsa ts'ebetso, ho boloka metsi le ho khomarela. E ntlafatsa ts'ebetso ea lisebelisoa tsena tsa mohaho maemong a sa tšoaneng.
Litlolo: HPMC e sebelisoa e le setenya, emulsifier le stabilizer mefuteng ea litlolo tse kang litlolo, litlolo le li-gel. E fana ka thepa e lakatsehang ea rheological mme e matlafatsa botsitso ba sehlahisoa.
Hydroxypropyl methylcellulose (HPMC) ke motsoako o sebetsang ka bongata o entsoeng ho tloha selulose ka mekhoa ea methylation le hydroxypropylation. Sebopeho sa eona sa lik'hemik'hale, thepa le lits'ebetso li etsa hore e be motsoako oa bohlokoa liindastering tse fapaneng joaloka meriana, lijo, kaho le litlolo. Lipatlisiso tse ling le nts'etsopele ea theknoloji ea HPMC e ntse e tsoela pele ho holisa lits'ebetso tsa eona tse ka bang teng le ho ntlafatsa ts'ebetso ea eona mekhoeng e fapaneng.
Nako ea poso: Feb-20-2024