Hydroxypropyl methylcellulose (HPMC) ke lik'hemik'hale tse sebetsang ka bongata tse sebelisoang haholo lefapheng la indasteri. Ke ether e seng ea ionic cellulose, haholo-holo e fumanoang ka ho fetola lik'hemik'hale tsa cellulose ea tlhaho. Likarolo tsa eona tsa mantlha ke hore lihlopha tsa hydroxyl ka har'a limolek'hule tsa cellulose li nkeloa sebaka ke lihlopha tsa methoxy le hydroxypropyl. HPMC e sebelisoa haholo mafapheng a mangata a kang a kaho, liaparo, meriana, lijo le litlolo ka lebaka la thepa ea eona e ikhethang ea 'mele le lik'hemik'hale.
1. Lintho tsa 'mele le tsa lik'hemik'hale
HPMC e na le ho qhibiliha ha metsi hantle 'me e ka qhibiliha ka potlako metsing a batang ho etsa tharollo e hlakileng kapa e nyenyane ea milky colloidal. Tharollo ea eona ea metsi e na le viscosity e phahameng, 'me viscosity ea eona e amana le mahloriso, mocheso le tekanyo ea ho fetola tharollo. HPMC e tsitsitse ka mefuta e mengata ea pH mme e na le mamello e ntle ho li-acids le alkalis. Ho phaella moo, e na le mekhoa e metle ea ho etsa filimi, ho khomarela, ho boloka metsi le thepa e teteaneng.
2. Mokhoa oa tlhahiso
Ts'ebetso ea tlhahiso ea HPMC haholo-holo e kenyelletsa mehato e kang kalafo ea alkali, karabelo ea etherification le kalafo ea morao-rao. Ntlha ea pele, cellulose ea tlhaho e kenngoa pele tlas'a maemo a alkaline ho e sebelisa, ebe e etherified le methoxylating agents le hydroxypropylating agents, 'me qetellong sehlahisoa sa ho qetela se fumanoa ka ho se nke lehlakore, ho hlatsoa, ho omisa le ho senya. Nakong ea ts'ebetso ea tlhahiso, maemo a karabelo a kang mocheso, khatello, nako ea karabelo le palo ea li-reagents tse fapaneng li tla ama boleng le ts'ebetso ea HPMC.
3. Libaka tsa kopo
3.1 Indasteri ea kaho
Indastering ea kaho, HPMC e sebelisoa haholo-holo e le sekontiri, se tlamang le se bolokang metsi bakeng sa seretse sa samente. E ka ntlafatsa ts'ebetso, ts'ebetso ea kaho le matla a tlamahano ea seretse, ha e ntse e fokotsa ho honyela le ho phatloha ha seretse.
3.2 Indasteri ea ho roala
HPMC e sebelisoa e le motenya, dispersant le stabilizer indastering ea ho roala. E ka ntlafatsa thepa ea rheological ea ho roala, ho etsa hore ho be bonolo ho borashe, le ho ntlafatsa ho khomarela le ho bata ha seaparo.
3.3 Liindasteri tsa meriana le lijo
Lefapheng la meriana, HPMC e sebelisoa e le sesebelisoa sa ho etsa lifilimi, moemeli oa tokollo e tsitsitseng le stabilizer bakeng sa matlapa a lithethefatsi. E ka laola lebelo la ho lokolloa ha lithethefatsi le ho ntlafatsa botsitso ba lithethefatsi. Indastering ea lijo, HPMC e sebelisoa e le tlatsetso ea ho tenya, emulsify, ho emisa le ho tsitsisa lijo.
3.4 Indasteri ea Litlolo
Ka litlolo, HPMC e sebelisoa e le motenya, pele filimi le stabilizer. E ka ntlafatsa sebopeho le boiphihlelo ba ts'ebeliso ea litlolo, 'me ea ntlafatsa botsitso le thepa ea moisturizing ea lihlahisoa.
4. Melemo le Mathata
Joalo ka lik'hemik'hale tse fapaneng tse sebetsang, HPMC e bonts'itse melemo ea ts'ebeliso ea bohlokoa mafapheng a fapaneng a indasteri. Ntlha ea pele, e tsoa ho cellulose ea tlhaho 'me e na le lisebelisoa tse ntle tsa biocompatibility le tšireletso ea tikoloho. Ea bobeli, HPMC e na le botsitso bo phahameng ba lik'hemik'hale 'me e ka boloka ts'ebetso ea eona tlas'a maemo a fapaneng a tikoloho. Leha ho le joalo, ts'ebetso ea tlhahiso ea HPMC e rarahane ebile e na le litlhoko tse phahameng tsa lisebelisoa tsa tlhahiso le theknoloji. Ho feta moo, botsitso ba boleng le botsitso ba ts'ebetso lipakeng tsa lihlopha tse fapaneng tsa lihlahisoa le tsona ke litaba tse hlokang tlhokomelo.
5. Mekhoa ea Tsoelo-pele ea Kamoso
Ka tsoelopele ea mahlale le thekenoloji le liphetoho tlhokehong ea mmaraka, litebello tsa ts'ebeliso ea HPMC li tla ba pharalletseng. Lebaleng la kaho, HPMC e tla bapala karolo e kholo ho thepa e ncha ea moaho le meahong e tala. Lefapheng la meriana le lijo, HPMC e tla sebelisoa haholo ha maemo a bophelo bo botle le polokeho a ntlafala. Ho phaella moo, ha batho ba ela hloko haholo ts'ireletso ea tikoloho le nts'etsopele e tsitsitseng, HPMC, e le mohloli o tsosolositsoeng, e tla bontša melemo ea eona ea tikoloho libakeng tse ngata.
Hydroxypropyl methylcellulose (HPMC) e fetohile lisebelisoa tsa bohlokoa tsa lik'hemik'hale tlhahiso ea indasteri ka lebaka la thepa ea eona e ikhethang le masimo a mangata a kopo. Nakong e tlang, ka tsoelo-pele e tsoelang pele ea thekenoloji le katoloso e tsoelang pele ea libaka tsa kopo, HPMC e tla bapala karolo ea bohlokoa mafapheng a mangata, ho tlisa menyetla e mecha le liphephetso ntlafatsong ea liindasteri tse fapa-fapaneng.
Nako ea poso: Jul-31-2024