Hydroxypropylmethylcellulose (HPMC) ke polymer e sebetsang ka bongata e sebelisoang liindastering tse fapaneng, ho kenyeletsoa meriana, kaho, lijo le litlolo. E 'ngoe ea lisebelisoa tsa eona tse tloaelehileng ke ho etsoa ha lihlahisoa tsa gel. Li-gel ke litsamaiso tsa semisolid tse nang le thepa e ikhethang ea rheological, mme ts'ebetso ea bona e ka angoa ke lintlha tse fapaneng, ho kenyelletsa mocheso.
tsebisa
Hydroxypropylmethylcellulose (HPMC) ke ntho e tsoang ho cellulose e entsoeng ka ho phekola cellulose ka propylene oxide le methyl chloride. Ke ea lelapa la cellulose ether 'me e na le thepa e qhibilihang ka metsing le ea gelling. HPMC e sebelisoa haholo indastering ea meriana, ea lijo, ea kaho le ea litlolo ka lebaka la bokhoni ba eona bo botle ba ho etsa lifilimi, botenya le li-gelling.
Ho kenngoa ha HPMC
Gelation ke ts'ebetso eo mokelikeli kapa sol e fetohang gel, boemo bo tiileng bo nang le lintho tse metsi le tse tiileng. HPMC gels ka mochine oa hydration le sebopeho sa marangrang a mararo-dimensional. Ts'ebetso ea gelation e angoa ke lintlha tse kang mahloriso a polymer, boima ba limolek'hule le mocheso.
Ho itšetlehile ka mocheso oa gelation
Mocheso o bapala karolo ea bohlokoa boitšoarong ba HPMC. Kamano pakeng tsa mocheso le gelation e ka ba e rarahaneng, 'me ho bohlokoa ho utloisisa hore na liphetoho tsa mocheso li ama thepa ea li-gel tsa HPMC joang. Ka kakaretso, gelation ea HPMC ke ts'ebetso e makatsang, ho bolelang hore e lokolla mocheso.
1. Kakaretso ea li-gel tsa mocheso
Thermal gelation curves ea HPMC e khetholloa ke mocheso oa mocheso oa gelation, ke hore mocheso oa mocheso moo phetoho ea ho tloha Sol ho ea ho gel e etsahala. Mocheso oa mocheso oa gelation o angoa ke mahloriso a HPMC ka tharollo. Lithempereichara tse phahameng hangata li baka mocheso o phahameng oa gelling.
2. Phello ho viscosity
Mocheso o ama viscosity ea tharollo ea HPMC mme ka hona ts'ebetso ea gelation. Ha mocheso o ntse o eketseha, viscosity ea tharollo ea HPMC ea fokotseha. Ho fokotseha ha viscosity ho ama matla a li-gel le thepa ea ho qetela ea li-gel. Mocheso o tlameha ho laoloa ka hloko le ho behoa leihlo nakong ea ho etsoa ho finyella viscosity e lakatsehang le thepa ea gel.
Lintho tse amang mocheso oa gel
Lintlha tse 'maloa li susumetsa mocheso oa gel oa HPMC,' me ho utloisisa lintlha tsena ho bohlokoa ho baetsi ba lihlahisoa le bafuputsi.
1. Polymer concentration
Khokahano ea HPMC ka foromo ke ntlha ea bohlokoa e amang mocheso oa gelation. Lithempereichara tse phahameng hangata li baka mocheso o phahameng oa gelation. Kamano ena e bakoa ke palo e ntseng e eketseha ea liketane tsa polymer tse fumanehang bakeng sa litšebelisano tsa limolek'hule, tse hlahisang marang-rang a matla a li-gel.
2. Boima ba molek'hule ea HPMC
Boima ba limolek'hule ba HPMC bo boetse bo ama gelation. Boima bo phahameng ba limolek'hule HPMC e ka bonts'a mocheso o fapaneng oa gel ha o bapisoa le boima bo tlase ba limolek'hule HPMC. Boima ba limolek'hule bo ama ho qhibiliha ha polymer, ho kenngoa ha ketane, le matla a marang-rang a gel a thehoa.
3. Sekhahla sa metsi
Sekhahla sa hydration sa HPMC se angoa ke mocheso. Lithempereichara tse phahameng li potlakisa ts'ebetso ea hydration, e etsang hore ho be le gelation e potlakileng. Sena ke sa bohlokoa ka ho khetheha bakeng sa li-formulation tse sa tsotelleng nako tse hlokang gelation e potlakileng.
4. Ho ba teng ha li-additives
Ho ba teng ha li-additives tse kang plasticizers kapa letsoai ho ka fetola mocheso oa gelling oa HPMC. Li-additives tsena li ka sebelisana le liketane tsa polymer, tse amang bokhoni ba tsona ba ho theha marang-rang a li-gel. Baqapi ba tlameha ho nahana ka hloko phello ea li-additives boitšoarong ba li-gel.
Bohlokoa bo sebetsang le lits'ebetso
Ho utloisisa boitšoaro ba gel e itšetlehileng ka mocheso oa HPMC ho bohlokoa bakeng sa ho etsa lihlahisoa tse nang le boleng bo tsitsitseng le tshebetso. Kutloisiso ena e fana ka litlamorao tse 'maloa tse sebetsang le ts'ebeliso.
1. Lithethefatsi tse lokolloang tse laoloang
Indastering ea meriana, HPMC e atisa ho sebelisoa mefuteng ea litlhare tse laoloang. Boikutlo ba mocheso oa li-gel tsa HPMC bo ka sebelisoa ho laola ho lokolloa ha metsoako e sebetsang ea meriana. Ka ho lokisa mocheso oa gelation ka hloko, li-formalator li ka khona ho fetola li-profiles tsa tokollo ea lithethefatsi.
2. Li-hydrogel tse arabelang mocheso
Boikutlo ba mocheso oa HPMC bo etsa hore e tšoanelehe bakeng sa nts'etsopele ea li-hydrogel tse arabelang mocheso. Li-hydrogel tsena li ka ba le liphetoho tse fetolehang tsa sol-gel ho latela liphetoho tsa mocheso, tsa etsa hore e be tsa bohlokoa bakeng sa lits'ebetso tse joalo ka pholiso ea maqeba le phano ea lithethefatsi.
3. Lisebelisoa tsa mohaho
Ka indasteri ea kaho, HPMC hangata e sebelisoa e le tlatsetso ea thepa e thehiloeng ho samente ho ntlafatsa ts'ebetso le ho boloka metsi. Boikutlo ba mocheso oa HPMC bo ama nako ea ho beha le thepa ea rheological ea lisebelisoa tsena, kahoo e ama ts'ebetso ea bona nakong ea kaho.
Mathata le Litharollo
Le hoja boitšoaro ba gel bo itšetlehileng ka mocheso oa HPMC bo fana ka melemo e ikhethang, bo boetse bo baka mathata lits'ebetsong tse itseng. Ka mohlala, ho finyella thepa ea li-gel e tsitsitseng ho ka ba phephetso ho metsoako moo liphetoho tsa mocheso li tloaelehileng. Baqapi ba tlameha ho nahana ka mathata ana le ho sebelisa maano a ho a rarolla.
1. Ho laola mocheso nakong ea litokisetso
Ho etsa bonnete ba hore li-gel li sebetsa hantle, ho bohlokoa ho laola mocheso o tiileng nakong ea ho etsoa. Sena se ka kenyelletsa ho sebelisa thepa ea ho kopanya e laoloang ke mocheso le ho shebella mocheso nakong eohle ea tlhahiso.
2. Khetho ea polima
Ho bohlokoa ho khetha kereiti e nepahetseng ea HPMC e nang le litšobotsi tse lakatsehang tsa mocheso oa gel. Limaraka tse fapaneng tsa HPMC li fumaneha ka litekanyo tse fapaneng tsa limolek'hule le maemo a phalliso, a lumellang baetsi ba lihlahisoa ho khetha polymer e loketseng ts'ebeliso ea bona e ikhethang.
3. Tlatsetso optimization
Ho ba teng ha li-additives ho ama mocheso oa gelling oa HPMC. Moetsi oa thepa a ka 'na a hloka ho ntlafatsa mofuta le motsoako oa li-additives ho finyella thepa e lakatsehang ea gel. Sena se hloka mokhoa o hlophisitsoeng le kutloisiso e phethahetseng ea tšebelisano pakeng tsa HPMC le li-additives.
Hydroxypropylmethylcellulose (HPMC) ke polymer e sebetsang ka bongata e nang le thepa e ikhethang ea gel e angoang ke mocheso. Gelation e itšetlehileng ka mocheso oa HPMC e na le litlamorao tse kholo bakeng sa liindasteri tse 'maloa ho kenyelletsa le tsa meriana, kaho le litlolo. Ho utloisisa lintlha tse susumetsang mocheso oa gelation, joalo ka polymer concentration, boima ba molek'hule, le boteng ba li-additives, ho bohlokoa ho baetsi ba lihlahisoa ba batlang ho ntlafatsa ts'ebetso ea gel bakeng sa lits'ebetso tse ikhethileng.
Ha theknoloji e ntse e tsoela pele le lipatlisiso tsa saense tsa polymer li ntse li tsoela pele, kutloisiso e eketsehileng ea boitšoaro bo itšetlehileng ka mocheso oa HPMC e ka lebisa ho nts'etsopele ea mekhoa e mecha le lisebelisoa. Bokhoni ba ho lokisa thepa ea lijeli bo bula menyetla e mecha ea ho rala thepa e nang le thepa e ikhethileng, e thusang tsoelo-pele ea phano ea lithethefatsi, biomaterials le likarolo tse ling.
Nako ea poso: Jan-11-2024