Hydroxypropyl Methyl Cellulose HPMC

Hydroxypropyl methylcellulose(HPMC) ke motsoako oa cellulose o sebelisoang hangata liindastering tse fapaneng, ho kenyeletsoa meriana, lijo, kaho le tlhokomelo ea motho. E entsoe ka ho fetola selulose ka lik'hemik'hale ka etherification, e kenyelletsang ho hlahisa lihlopha tsa hydroxypropyl le methyl ka har'a molek'hule ea cellulose.

HPMC ke phofo e tšoeu ho isa ho e tšoeu e sa nkhang hamonate ka metsing 'me e etsa tharollo e hlakileng, e hlakileng. E na le lisebelisoa tse fapaneng tse etsang hore e be molemo lits'ebetsong tse fapaneng. Ka mohlala, ke ntho e teteaneng, e tsitsitseng, le emulsifier lihlahisoa tsa lijo. Kahong, e sebelisoa e le ntho ea ho boloka metsi ka samenteng le seretseng ho ntlafatsa ts'ebetso le ho thibela ho peperana. Lihlahisoang tsa tlhokomelo ea motho, e sebelisoa e le seteifatsi le emulsifier ho lotion, litlolo, le lihlahisoa tse ling.

Litlhareng tsa meriana, HPMC e sebelisoa e le se tlamellang, se senyang, le ho lokolloa ho laoloa ka matlapa le li-capsules. E boetse e sebelisoa e le moemeli oa ho emisa linthong tsa metsi le joalo ka setlolo sa mafura le litlolo. HPMC ke mothusi ea amoheloang hohle indastering ea meriana ka lebaka la ho lumellana ha eona, polokeho le chefo e tlase.

HPMC e na le limaraka tse 'maloa tse nang le maemo a fapaneng a viscosity, a khethiloeng ka khoutu ea linomoro. Ha palo e phahame, e na le viscosity e phahameng. Limaraka tsa HPMC li tloha ho viscosity e tlase (5 cps) ho ea ho viscosity e phahameng (100,000 cps). Viscosity ea HPMC ke ntlha ea bohlokoa ho khethollang thepa le lits'ebetso tsa eona.

Ts'ebeliso ea HPMC ho tsa meriana e holile lilemong tsa morao tjena ka lebaka la thepa ea eona e fapaneng le tlhokahalo e ntseng e eketseha ea lits'ebetso tse ncha tsa phepelo ea lithethefatsi. Li-hydrogel tse thehiloeng ho HPMC li 'nile tsa sebelisoa lits'ebetsong tsa phano ea lithethefatsi ka lebaka la ho lumellana ha tsona le biocompatibility, tokollo e laoloang, le thepa ea ho khomarela mucoadhesive. Matlapa a thehiloeng ho HPMC le 'ona a entsoe ka thepa e fetotsoeng ea tokollo e lumellang phepelo e lebisitsoeng ea lithethefatsi le ho ntlafatsa ho latela melao ea bakuli.

Leha ho le joalo, HPMC ha e na meeli ea eona. E na le sollubility e fokolang ka har'a metsoako ea tlhaho 'me e na le maikutlo a feto-fetohang a pH. Ho phaella moo, e na le mocheso o fokolang oa mocheso 'me o ka lahleheloa ke viscosity ka mocheso o phahameng. Mefokolo ena e lebisitse ho nts'etsopele ea lihlahisoa tse ling tsa cellulose, tse kang hydroxyethyl cellulose (HEC) le carboxymethyl cellulose (CMC), tse nang le thepa e ntlafetseng le mefuta e mengata ea tšebeliso.

Qetellong, HPMC ke motsoako oa selulose o sebetsang ka mokhoa o fapaneng o sebelisoang haholo liindastering tse fapaneng, haholo litlhare. Thepa ea eona e ikhethang, ho kenyelletsa le biocompatibility, polokeho, le chefo e tlase, e etsa hore e be mothusi ea tsebahalang mekhoeng ea lithethefatsi. Litsamaiso tsa phano ea lithethefatsi tse thehiloeng ho HPMC li bonts'itse ts'episo ea ho ntlafatsa ts'ebetso ea lithethefatsi le ho latela melao ea mokuli. Leha ho le joalo, mefokolo ea eona ho solubility le pH sensitivity e lebisitse ho nts'etsopele ea lihlahisoa tse ling tsa cellulose tse nang le thepa e ntlafetseng.