Mehaho ea Li-additives Hydroxypropyl Methylcellulose Metsi a Batang a Qhalang

Hydroxypropyl methylcellulose (HPMC) ke semi-synthetic, polymer e qhibilihang ka metsing e entsoeng ka selulose. E sebelisoa haholo liindastering tse fapaneng tse kang tsa meriana, lijo, litlolo, le kaho ka lebaka la thepa ea eona e babatsehang, ho kenyelletsa le bokhoni bo botle ba ho etsa lifilimi, botenya, ho tlama le ho boloka metsi.

E 'ngoe ea likarolo tsa bohlokoa ka ho fetisisa tsa HPMC ke bokhoni ba eona ba ho qhibiliha ka metsing a batang, e leng se etsang hore e be khetho e ratoang ka ho fetisisa lits'ebetsong tse hlokang ts'ebetso e potlakileng le e bonolo ea ho qhibiliha. Sehloohong sena, re tla hlahloba litšobotsi tsa HPMC, mekhoa ea ho qhibiliha ha metsi a batang, le lisebelisoa tsa eona.

Thepa ea Hydroxypropyl Methylcellulose

HPMC ke phofo e tšoeu ho isa ho e tšoeu e sa nkheng, e sa latsoeheng, ebile e se chefo. E na le botsitso bo botle ba mocheso 'me e khona ho mamella mefuta e mengata ea pH ea boleng. HPMC e qhibiliha ka metsing 'me e etsa litharollo tse hlakileng, tse nang le li-viscous tse nang le pH e nang le asiti hanyane.

Thepa ea 'mele le ea lik'hemik'hale ea HPMC e ka fetoloa ka ho fetola tekanyo ea eona ea ho fetola (DS) le boima ba eona ba molek'hule. DS e bolela palo ea lihlopha tsa hydroxyl ka har'a molek'hule ea selulose tse nkeloang sebaka ke sehlopha sa methyl kapa hydroxypropyl. Ha DS e phahame, palo ea lihlopha tse nketsoeng sebaka e ngata haholo, e leng se etsang hore boima ba molek'hule bo fokotsehe le ho qhibiliha ho hoholo ha metsi.

Boima ba limolek'hule tsa HPMC le tsona li ka ama ho solubility, viscosity, le thepa ea gelation. Boima bo phahameng ba limolek'hule HPMC e atisa ho ba le viscosity e phahameng le matla a gel, ha boima bo tlaase ba molek'hule HPMC e na le ho qhibiliha ho molemo metsing a batang.

Mekhoa ea ho qhibiliha ha metsi a batang

Ho qhibiliha ha metsi a batang a HPMC haholo-holo ho bakoa ke mekhoa e 'meli: hydrogen bonding le steric hindrance.

Ho tlamahanngoa ha hydrogen ho etsahala ha lihlopha tsa hydroxyl ho molek'hule ea HPMC li sebelisana le limolek'hule tsa metsi ka li-bond tsa haedrojene. Lihlopha tsa hydroxypropyl le methyl ho HPMC le tsona li ka nka karolo ho tlamahaneng ha haedrojene le limolek'hule tsa metsi, ho ntlafatsa ho qhibiliha ha metsi.

Thibelo ea steric e bolela ho sitisoa 'meleng ha liketane tsa cellulose ke lihlopha tse ngata tsa hydroxypropyl le methyl. Tšitiso ea steric e thibela limolek'hule tsa HPMC ho theha likamano tse matla tsa li-intermolecular, e leng se etsang hore ho be le ho ntlafala ha metsi.

Lisebelisoa tsa Hydroxypropyl Methylcellulose

HPMC e sebelisoa haholo liindastering tse sa tšoaneng ka lebaka la thepa ea eona e babatsehang. Tse ling tsa lisebelisoa tsa eona ke tsena:

Meriana ea Meriana: HPMC e sebelisoa ka tloaelo e le setlamo, se senyang, le ho etsa lifilimi matlapeng a meriana le li-capsules. E boetse e sebelisoa e le motenya le stabilizer ho ophthalmic le nasal formulations.

Lijo: HPMC e sebelisoa e le setei, emulsifier, le stabilizer lihlahisoa tse fapaneng tsa lijo tse kang ice cream, yoghurt le liaparo tsa salate. E boetse e sebelisoa e le sesebelisoa sa ho roala litholoana le meroho ho ntlafatsa ponahalo ea tsona le bophelo ba sethala.

Litlolo: HPMC e sebelisoa e le seteifatsi, emulsifier, le ntho e etsang filimi litlolong le lihlahisoa tsa tlhokomelo ea motho tse kang litlolo, li-shampoo le li-conditioner.

Kaho: HPMC e sebelisoa e le ntho ea ho boloka metsi, e teteaneng le e tlamang linthong tsa samente tse kang seretse le samente. E ntlafatsa ts'ebetso, e fokotsa ho phatloha, 'me e ntlafatsa ho khomarela.

Lisebelisoa tse ling: HPMC e boetse e sebelisoa lits'ebetsong tse ling tse fapaneng joalo ka khatiso ea masela, lipente le lipente tsa ho roala, le li-inks.