Hydroxypropyl Methyl Cellulose (HPMC), eo hape e tsejoang e le hypromellose, ke polymer e feto-fetohang, e entsoeng ka halofo e sebelisoang haholo liindastering tse fapaneng ka lebaka la thepa ea eona e ikhethang ea lik'hemik'hale le 'mele. Ke motsoako oa cellulose, moo lihlopha tsa hydroxyl tsa molek'hule ea cellulose li nkeloang sebaka ke lihlopha tsa methoxy (-OCH3) le hydroxypropyl (-CH2CHOHCH3). Phetoho ena e fa HPMC ka litšobotsi tse 'maloa tse molemo, e etsa hore e be ea bohlokoa indastering ea meriana, ea kaho, ea lijo le ea litlolo.
Sebopeho sa Lik'hemik'hale le Thepa
HPMC e tsoa ho selulose, polymer ea tlhaho e ngata ka ho fetisisa, ka letoto la karabelo ea lik'hemik'hale. Mokhoa ona o kenyelletsa ho phekola selulose ka sodium hydroxide ho etsa alkali cellulose, e lateloe ke etherification ka methyl chloride le propylene oxide. Sena se fella ka hore ho nkeloe sebaka sa lihlopha tse ling tsa hydroxyl mokokotlong oa cellulose ka lihlopha tsa methoxy le hydroxypropyl. Tekanyo ya phapanyetso (DS) le molar substitution (MS) e bontsha hore na sehlahiswa sa ho qetela ke sa boleng le ho qhibiliha ha sehlahiswa. HPMC hangata e na le DS ea 1.8-2.0 le MS ea 0.1-0.2.
Thepa ea Bohlokoa
Solubility: HPMC e qhibiliha ka metsing a batang empa ha e qhibilihe metsing a chesang. E etsa gel ha e futhumatsa, e leng thepa e tsejoang e le thermal gelation, e khutlisetsoang morao ha ho pholile. Sena se etsa hore e be molemo ka ho khetheha lits'ebetsong tseo ho tsona ho lakatsehang ho qhibiliha ho itšetlehileng ka mocheso.
Viscosity: Litharollo tsa HPMC li bonts'a boits'oaro boo e seng ba Newtonian, ba ho sesa, ho bolelang hore viscosity ea bona e fokotseha ka sekhahla se ntseng se eketseha sa ho kuta. Thepa ena e na le molemo ho liforomo tse hlokang thepa ea phallo e laoloang, joalo ka lipente le liphahlo.
Bokhoni ba ho Etsa Lifilimi: HPMC e ka etsa lifilimi tse matla, tse tenyetsehang, le tse pepeneneng, e leng se etsang hore e be filimi e ntle ea pele ea meriana (bakeng sa matlapa a ho roala) le lisebelisoa tsa lijo.
Biocompatibility le Tšireletseho: HPMC ha e chefo, ha e tenehe ebile e lumellana le lintho tse phelang, e lumellang tšebeliso ea eona ho meriana, litlolo le lihlahisoa tsa lijo ntle le liphello tse mpe tsa bophelo bo botle.
Likopo ho Liindasteri tse fapaneng
Indasteri ea Meriana
HPMC e sebelisoa haholo indastering ea meriana ka lebaka la thepa ea eona e fapaneng:
Litlhophiso tsa Phallo e Laolehileng: HPMC ke motsoako oa bohlokoa ho thehoeng ha matlapa a lokolotsoeng a laoloang. Bokhoni ba eona ba ho ruruha le ho etsa lesela la gel ha le kopana le metsi a ka mpeng le lumella ho lokolloa butle le ho laoloa ha metsoako e sebetsang ea meriana (APIs).
Ho roala Letlapa: Bokhoni ba eona ba ho etsa filimi bo sebelisetsoa ho roala matlapa, ho fana ka thibelo e sireletsang khahlanong le mongobo, oksijene le leseli, kahoo ho matlafatsa botsitso ba meriana.
Thickening Agent: HPMC e sebetsa e le ntho e matlafatsang mekhoeng e fapaneng ea mokelikeli, joalo ka li-syrups le li-suspensions, ho netefatsa hore ho na le ts'ebetso e ts'oanang le botsitso.
Indasteri ea Kaho
Lefapheng la kaho, HPMC e sebelisoa lihlahisoa tse kang:
Lihlahisoa tse Thehiloeng ka Samente le Gypsum: HPMC e ntlafatsa bokhoni ba ho sebetsa, ho boloka metsi, le thepa ea ho khomarela samente le gypsum plasters. E ntlafatsa nako e bulehileng, e fokotsa ho sisinyeha, 'me e ntlafatsa boreleli le pheletso ea thepa e sebelisitsoeng.
Likhomaretsi tsa Lithaele: E fana ka polokelo e ntle ea metsi, e eketsa nako ea ho sebetsa le ho ntlafatsa matla a tlamahano ea likhomaretsi tsa lithaele.
Indasteri ea Lijo
HPMC e hiriloe joalo ka tlatsetso ea lijo (E464) ka merero e fapaneng:
Thickening and Stabilizing Agent: E sebelisetsoa ho tiisa le ho tsitsisa li-sauces, dressings le sopho. Bokhoni ba eona ba ho etsa li-gel le ho tsitsisa li-emulsion ke ba bohlokoa ka ho khetheha lihlahisoa tse mafura a tlaase le tse se nang gluten.
Mekhoa e meng ea Vegetarian le Vegan: HPMC e sebelisoa ho theha mefuta e meng ea nama le lebese, ho fana ka sebopeho le botsitso ho lihlahisoa tse kang nama e entsoeng ka limela le lichisi tse se nang lebese.
Indasteri ea Litlolo
Ho litlolo, HPMC e bohlokoa bakeng sa:
Thepa e matlafatsang le e matlafatsang: E sebelisoa ka litlolo, litlolo, le li-shampoo ho fana ka botsitso bo lakatsehang le ho ntlafatsa botsitso ba li-emulsion.
Bokhoni ba ho etsa lifilimi: HPMC e thusa ho theha mokoallo o sireletsang letlalong kapa moriring, ho ntlafatsa ts'ebetso ea sehlahisoa le ho phela halelele.
Melemo le Mefokolo
Melemo:
Ho feto-fetoha ha maemo: Bokhoni ba HPMC ba ho etsa mesebetsi e mengata-ho tenyetseha, ho tenyetseha, ho etsa lifilimi, ho tsitsisa-ho etsa hore e feto-fetohe haholo.
Polokeho: Ho hloka chefo, tlhaho ea eona e sa hloekiseng e etsa hore e tšoanelehe ho sebelisoa lijong, meriana, le lihlahisoa tsa tlhokomelo ea botho.
Biodegradability: Kaha ke motsoako oa selulose, HPMC e ka senyeha, e leng molemo ho latela pono ea tikoloho.
Meeli:
Mathata a Solubility: Le hoja HPMC e qhibiliha ka metsing a batang, e ka etsa maqhubu haeba e sa qhalakanngoe hantle. Mekhoa le lisebelisoa tse nepahetseng lia hlokahala ho etsa bonnete ba ho qhibiliha ho tšoanang.
Litšenyehelo: HPMC e ka ba theko e boima haholo ha e bapisoa le li-thickeners le li-stabilizer tse ling, tse ka fokotsang tšebeliso ea eona lits'ebetsong tse sa tsotelleng litšenyehelo.
Tlhokahalo ea HPMC e lebelletsoe ho hola ka lebaka la likopo tse ntseng li eketseha liindastering tse fapaneng, haholoholo ka mokhoa o ntseng o hola oa lihlahisoa tse tšoarellang le tse thehiloeng ho limela. Litlhahiso tsa mekhoa ea tlhahiso le mekhoa e mecha li ka ntlafatsa boleng ba eona le ho atolosa tšebeliso ea eona.
Lipatlisiso le Ntlafatso
Patlisiso e ntseng e tsoela pele e tsepamisitse maikutlo ho ntlafatseng thepa ea ts'ebetso ea HPMC ka liphetoho tsa lik'hemik'hale le ho tsoakana le lipolima tse ling. Lintlafatso lits'ebetsong tsa tlhahiso li ikemiselitse ho fokotsa litšenyehelo le tšusumetso ea tikoloho, ho etsa hore HPMC e be khetho e ntle le ho feta bakeng sa liindasteri tse fapaneng.
Hydroxypropyl Methyl Cellulose (HPMC) ke polymer e sebetsang haholo ebile e fetoha le maemo e nang le lits'ebetso tse pharalletseng liindasteri tse fapaneng. Lintho tsa eona tse ikhethang tse kang solubility, viscosity control, bokhoni ba ho etsa lifilimi, le polokeho li etsa hore e be ea bohlokoa haholo ho tsa meriana, kaho, lijo le litlolo. Leha ho na le mefokolo e itseng, melemo ea eona le monyetla oa lintlafatso tsa nako e tlang li netefatsa hore HPMC e tla tsoelapele ho bapala karolo ea bohlokoa tlhahisong ea lihlahisoa le tsoelopeleng ea indasteri.
Nako ea poso: May-24-2024