Hydroxy Ethyl Cellulose: E 'ngoe ea Mothusi oa Sebopeho sa Lithethefatsi

Hydroxyethyl cellulose (HEC) ke polymer e se nang ionic e qhibilihang ka metsing e tsoang ho selulose, e sebelisoang haholo indastering ea meriana e le mohloli oa mantlha oa metsoako ea lithethefatsi. HEC e na le mefuta e fapaneng ea thepa, ho kenyeletsoa ho teteana, ho tsitsisa, le ho emisa, e leng se etsang hore e be mothusi ea loketseng bakeng sa mefuta e mengata ea likopo. Sehloohong sena, re tla hlahloba lits'ebetso tse fapaneng tsa HEC mekhoeng ea lithethefatsi le thepa ea eona e etsang hore e be mothusi oa bohlokoa indastering ea meriana.

1. Solubility le ho lumellana

HEC e qhibiliha haholo ka metsing 'me e lumellana le mefuta e mengata ea li-solvents, ho akarelletsa le alcohols, glycols, le metsi-miscible organic solvents. Sena se etsa hore e be mothusi ea loketseng bakeng sa mefuta e fapaneng ea litlhare, ho kenyeletsoa litlhare tsa molomo, tsa sehlooho, le tsa batsoali. E boetse e tsamaellana le lisebelisoa tse ling tse fapaneng, ho kenyeletsoa li-polymers, li-surfactants, le li-additives tse ling, tse etsang hore ho be bonolo ho li kenyelletsa mefuteng e fapaneng ea lithethefatsi.

2. Ho tenya le ho emisa

HEC ke ntho e sebetsang haholo e teteaneng le e emisang ka lebaka la bokhoni ba eona ba ho etsa sebopeho se kang gel ha se le metsi. Thepa ena e etsa hore e be molemo ha ho etsoa li-suspensions tsa molomo le li-emulsions, moo e thusang ho boloka botsitso le ho tšoana ha sehlahisoa. E boetse e na le thuso ha ho etsoa lihlahisoa tsa lihlooho, tse kang li-gel le litlolo, moo ho thusang ho fana ka mokhoa o boreleli, o tsitsitseng.

3. Bioadhesion

HEC e na le thepa e ntle ea bioadhesive, e etsang hore e be mothusi ea loketseng bakeng sa tlhahiso ea lihlahisoa tsa lithethefatsi tsa topical. Bioadhesion e bolela bokhoni ba thepa ho khomarela bokaholimo ba tlhaho, joalo ka letlalo kapa lera la mucous. Lintho tsa HEC tsa bioadhesive li etsa hore e be molemo ha ho etsoa mekhoa ea phepelo ea lithethefatsi ea transdermal, moo e thusang ho ntlafatsa ho khomarela ha patch letlalong.

4. Tokollo e laoloang

HEC e boetse e na le thuso ha ho etsoa lihlahisoa tsa lithethefatsi tse hlokang ho lokolloa ho laoloang. Bokhoni ba eona ba ho theha sebopeho se kang gel ha se hydrated se etsa hore e be mothusi ea loketseng bakeng sa ho etsoa ha lihlahisoa tsa lithethefatsi tsa molomo tse sa khaotseng. Sebopeho se kang gel se thusa ho laola ho lokolloa ha lithethefatsi ka nako e telele, e leng se ka thusang ho ntlafatsa ho latela melao ea mokuli le ho fokotsa makhetlo a mangata.

5. Botsitso

HEC ke excipient e tsitsitseng e ka mamellang maemo a mangata a ts'ebetso, ho kenyeletsa mocheso o phahameng le matla a ho kuta. Sena se etsa hore e be molemo ha ho etsoa lihlahisoa tsa lithethefatsi tse hlokang ho sebetsa ka mocheso o phahameng, joalo ka lihlahisoa tsa lyophilized. Ho tsitsa ha eona ho boetse ho thusa ho boloka botsitso ba sehlahisoa sa lithethefatsi nakong ea polokelo, e leng ea bohlokoa bakeng sa ho boloka katleho ea lithethefatsi.

6. Polokeho

HEC ke sesebelisoa se sireletsehileng se 'nileng sa sebelisoa indastering ea meriana ka lilemo tse ngata. Ha e na chefo ebile ha e halefise, e leng se etsang hore e be se loketseng ho sebelisoa lihlahisoa tsa lithethefatsi tsa molomo le tsa lihlooho. E boetse e lumellana le mefuta e mengata ea metsoako e sebetsang ea meriana (APIs), e leng se etsang hore ho be bonolo ho kenyelletsa metsoako e fapaneng ea lithethefatsi.

Likopo tsa HEC litlhahlobo tsa lithethefatsi

HEC ke mothusi ea nang le mefuta-futa ea fumanang likopo mefuteng e mengata ea litlhare. Tse ling tsa lisebelisoa tsa eona li kenyelletsa:

1. Ho emisoa ka molomo le li-emulsions: HEC e na le thuso ha ho etsoa li-suspension tsa molomo le li-emulsions, moo e thusang ho boloka botsitso le ho tšoana ha sehlahisoa.
2. Lihlahisoa tsa lihlooho: HEC e na le thuso ha ho etsoa lihlahisoa tsa lihlooho, tse kang li-gel le litlolo, moo e thusang ho fana ka mokhoa o boreleli, o tsitsitseng le ho ntlafatsa bioadhesion.
3. Mekhoa ea phepelo ea lithethefatsi ea Transdermal: Thepa ea HEC ea bioadhesive e etsa hore e be molemo ha ho etsoa litsamaiso tsa phepelo ea lithethefatsi tsa transdermal,

HEC e boetse e sebelisoa e le ntho e matlafatsang le e tsitsitseng lihlahisoa tse fapa-fapaneng tsa litlolo le tsa tlhokomelo ea botho tse kang litlolo, li-shampoo le sesepa sa meno. Indastering ea lijo, e sebelisoa e le sekontiri se teteaneng, se kopanyang le se etsang hore e be emulsifier lihlahisoa tse kang liaparo tsa salate, ice cream le lintho tse apehoang.

E 'ngoe ea melemo ea bohlokoa ea HEC ke bokhoni ba eona ba ho etsa gel ha e kopantsoe le metsi. Sena se etsa hore e be motsoako o loketseng bakeng sa litsamaiso tsa phepelo ea lithethefatsi tse hlokang tokollo e tsitsitseng ea metsoako e sebetsang. Lintho tse entsoeng ka li-gel tsa HEC li boetse li etsa hore e be molemo lihlahisoa tsa ho folisa maqeba le ho roala matlapa le li-capsules.

HEC e boetse e lumellana le biodegradable, e leng se etsang hore e be motsoako o khahlang bakeng sa litsamaiso tsa phepelo ea lithethefatsi. E sebelisitsoe lits'ebetsong tse fapaneng tsa phepelo ea lithethefatsi, ho kenyeletsoa li-microspheres, nanoparticles le hydrogel. HEC e ka boela ea sebelisoa ho kenyelletsa lisebelisoa tse sebetsang, ho li sireletsa ho senyeha le ho matlafatsa botsitso ba tsona.

Qetellong, HEC e na le lisebelisoa tse ngata tse sebetsang tse nang le lisebelisoa tse ngata indastering ea meriana, ea litlolo le ea lijo. Mehaho ea eona e ikhethang e etsa hore e be motsoako o loketseng bakeng sa lits'ebetso tsa phepelo ea lithethefatsi, lihlahisoa tsa pholiso ea maqeba, le lits'ebetso tse ling tse fapaneng. Ha lipatlisiso li ntse li tsoela pele, ho ka etsahala hore tšebeliso ea HEC e tsoele pele ho hōla le ho atoloha libakeng tse ncha.