Hydroxypropylmethylcellulose (HPMC) ke motsoako oa limolek'hule tse ngata tse 'nileng tsa sebelisoa haholo indastering ea kaho. E sebelisoa haholo lits'ebetsong tsa putty kaha e ntlafatsa ts'ebetso ea kakaretso le boleng ba putty. Sehloohong sena, re tla hlahloba ts'ebeliso ea HPMC ka putty, ho sekaseka mathata a ka hlahang nakong ea ts'ebeliso ea eona, 'me re arolelane malebela a ho qoba mathata ana.
Taba ea pele, a re ke re shebisiseng litšobotsi tsa HPMC. Ke nonionic cellulose ether, e qhibilihang ka metsing le metsoako e meng ea tlhaho. Sebopeho sa eona se ikhethang sa limolek'hule se e fa viscosity e ntle haholo, ho boloka metsi le thepa ea sekhomaretsi. Ka hona, ke tlatsetso e loketseng bakeng sa lits'ebetso tsa putty.
HPMC e ka sebelisoa e le sekontiri, se tlamang le se emulsifier ho li-putty formulations. E na le ts'ebetso e ntle ea ho boloka metsi e thusang ho thibela putty ho omella kapele haholo. E boetse e ntlafatsa ho khomarela ha putty ho substrate, e etsa hore e tšoarelle haholoanyane. Lintho tsena li etsa hore HPMC e be motsoako oa bohlokoa ho li-putty tsa boleng bo holimo.
Leha ho le joalo, mathata a mang a ka hlaha ha HPMC e sebelisoa ka putty. Bothata ba pele ke hore HPMC e na le maikutlo a pH le liphetoho tsa mocheso. Haeba pH ea motsoako oa putty e le asiti haholo, e ka etsa hore HPMC e lahleheloe ke viscosity. Ka nako e ts'oanang, haeba mocheso o phahame haholo, o tla etsa hore HPMC e fokotsehe, e leng se tla ama ts'ebetso ea putty.
Bothata bo bong bo ka hlahang ke clumping. Haeba HPMC e sa tsoakoa hantle le metsoako e meng ka foromo ea putty, e ka etsa li-clumps kapa clumps. Maqhubu ana a ama boleng ba putty, e etsa hore e se be boreleli ebile e thata ho e sebelisa.
Ho qoba mathata ana, melao e meng ea mantlha e tlameha ho lateloa ha o sebelisa HPMC lits'ebetsong tsa Putty. Taba ea pele, hoa hlokahala ho khetha mofuta o nepahetseng oa HPMC bakeng sa sebopeho sa putty. Mefuta e fapaneng ea HPMC e kanna ea ba le litšobotsi tse fapaneng, kahoo mofuta o nepahetseng o tlameha ho khethoa bakeng sa ts'ebeliso e itseng.
Taba ea bobeli, ho bohlokoa ho kopanya HPMC ka botlalo le lisebelisoa tse ling tsa sebopeho sa putty. Sena se tla thusa ho thibela maqeba kapa maqeba. Ho bohlokoa hape ho sebelisa mokhoa o nepahetseng oa ho kopanya ho netefatsa hore putty e tsoakane hantle.
Ntlha ea boraro, ela hloko pH le mocheso oa foromo ea putty. Ho bohlokoa ho netefatsa hore pH e ka har'a mefuta e khothaletsoang bakeng sa mofuta o itseng oa HPMC o sebelisoang. Ho bohlokoa hape ho beha leihlo mocheso oa motsoako le ho o boloka ka har'a sebaka se khothalelitsoeng ho thibela ho senyeha ha HPMC.
Ka kakaretso, HPMC ke motsoako oa bohlokoa mefuteng ea boleng bo holimo ea putty. E fana ka litšoaneleho tse ntle tsa ho boloka metsi, ho khomarela le viscosity tse ka ntlafatsang ts'ebetso le boleng ba li-putty. Leha ho le joalo, mathata a mang a ka 'na a hlaha nakong ea tšebeliso ea eona, a kang kutloisiso ho pH le liphetoho tsa mocheso, caking, joalo-joalo Ka ho latela melao e meng ea motheo ha u sebelisa HPMC, mathata ana a ka qojoa' me putty ea boleng bo phahameng e ka fumanoa.
Nako ea poso: Jul-27-2023