HPMC MOEKETSI

Hydroxypropyl Methylcellulose (HPMC) ke cellulose ether e nkiloeng ho selulose ea tlhaho, haholo-holo lehong kapa k'hothone, ka letoto la ts'ebetso ea lik'hemik'hale. Mona ke kakaretso ea metsoako le thepa ea HPMC:

1. Cellulose: Cellulose ke motsoako o ka sehloohong oa HPMC. Ke polysaccharide ea tlhaho e nang le likarolo tse pheta-phetoang tsa tsoekere tse hokahaneng hammoho ka liketane tse telele. Cellulose e sebetsa e le mokokotlo oa HPMC mme e fana ka botšepehi ba sebopeho.
2. Methylation: Mokokotlo oa cellulose o fetotsoe ka lik'hemik'hale ka mokhoa o bitsoang methylation, moo methyl chloride e sebetsanang le cellulose ka pel'a alkali ho hlahisa lihlopha tsa methyl (-CH3) holim'a ketane ea cellulose. Ts'ebetso ena ea methylation e bohlokoa bakeng sa ho ntlafatsa ho qhibiliha ha metsi le lisebelisoa tse ling tsa selulose.
3. Hydroxypropylation: Ho phaella ho methylation, lihlopha tsa hydroxypropyl (-CH2CHOHCH3) li ka boela tsa kenngoa ketane ea cellulose ka hydroxypropylation. Sena se tsoela pele ho fetola thepa ea selulose, ho ntlafatsa ho boloka metsi, bokhoni ba ho etsa filimi, le litšobotsi tse ling.
4. Etherification: Kenyelletso ea lihlopha tsa methyl le hydroxypropyl holim'a ketane ea cellulose e tsejoa e le etherification. Etherification e fetola sebopeho sa lik'hemik'hale tsa selulose, e leng se etsang hore ho thehoe HPMC e nang le thepa e ikhethang e loketseng lits'ebetso tse fapaneng.
5. Thepa ea 'Mele: HPMC ha e le hantle ke phofo e tšoeu ho ea ho e tšoeu, e sa nkheng, ebile e sa latsoeheng. E qhibiliha ka metsing a batang 'me e etsa litharollo tse hlakileng kapa tse fokolang hanyane ho itšetlehile ka mahloriso le kereiti. HPMC e bonts'a ts'ebetso e ntle ea ho boloka metsi, e teteaneng, ho etsa lifilimi, le thepa ea ts'ebetso ea holim'a metsi, e etsa hore e be ea bohlokoa liindastering tse fapaneng, ho kenyeletsoa kaho, meriana, lijo le litlolo.

Ka kakaretso, metsoako e ka sehloohong ho HPMC ke selulose, methyl chloride (bakeng sa methylation), le propylene oxide (bakeng sa hydroxypropylation), hammoho le li-catalysts tsa alkali le li-additives tse ling tse sebelisoang ts'ebetsong ea tlhahiso. Metsoako ena e ba le karabelo ea lik'hemik'hale ho hlahisa HPMC e nang le thepa e ikhethileng e etselitsoeng ho fihlela litlhoko tsa lits'ebetso tse fapaneng.