Hydroxypropyl methylcellulose (HPMC) ke polymer e feto-fetohang e sebelisoang haholo liindastering tse fapaneng ho kenyelletsa le tsa meriana, lijo le kaho. E 'ngoe ea likarolo tsa eona tsa bohlokoa ke ho boloka metsi, e leng se phethang karolo ea bohlokoa ho lekanyetsa katleho ea eona lits'ebetsong tse fapaneng.
1 Selelekela:
Hydroxypropylmethylcellulose (HPMC) ke polymer e thehiloeng ho cellulose e nkiloeng ho selulose ea tlhaho. E hohetse tlhokomelo bakeng sa bokhoni ba eona bo botle ba ho etsa lifilimi, thepa ea sekhomaretsi 'me, haholo-holo, thepa ea ho boloka metsi. Bokhoni ba ho ts'oara metsi ba HPMC ke karolo ea bohlokoa lits'ebetsong tse joalo ka thepa ea kaho, lihlahisoa tsa meriana le lihlahisoa tsa lijo.
2. Bohlokoa ba ho boloka metsi ho HPMC:
Ho utloisisa thepa ea ho boloka metsi ea HPMC ho bohlokoa ho ntlafatsa ts'ebetso ea eona lits'ebetsong tse fapaneng. Ka thepa ea mohaho, e tiisa ho khomarela hantle le ho sebetsa ha seretse le li-plaster. Litlhareng tsa meriana, e ama litlaleho tsa ho lokolloa ha lithethefatsi, 'me lijong, e ama sebopeho le bophelo ba sethala.
3. Lintlha tse amang ho boloka metsi:
Lintlha tse 'maloa li ama matla a ho tšoara metsi a HPMC, ho kenyelletsa boima ba limolek'hule, tekanyo ea ho fetola, mocheso le mahloriso. Ho utloisisa lintlha tsena ho bohlokoa ho rala liteko tse bonts'ang maemo a nnete a lefats'e ka nepo.
4. Mekhoa e tloaelehileng ea ho leka ho boloka metsi:
Mokhoa oa Gravimetric:
Beha lisampole tsa HPMC pele le ka mor'a ho qoelisoa metsing.
Bala matla a ho boloka metsi ka mokhoa o latelang: Sekhahla sa ho boloka metsi (%) = [(Boima ka mor'a ho koloba - Boima ba pele) / Boima ba pele] x 100.
index ea ho ruruha:
Keketseho ea molumo oa HPMC ka mor'a ho qoelisoa metsing e ile ea lekanyetsoa.
Index ea ho ruruha (%) = [(molumo ka mor'a ho qoelisoa - molumo oa pele)/molumo oa pele] x 100.
Mokhoa oa Centrifugation:
Centrifuge motsoako oa HPMC-metsi le ho lekanya bophahamo ba metsi a bolokiloeng.
Sekhahla sa ho boloka metsi (%) = (matla a ho boloka metsi / metsi a qalang) x 100.
Nuclear Magnetic Resonance (NMR):
Tšebelisano lipakeng tsa HPMC le limolek'hule tsa metsi e ile ea ithutoa ho sebelisoa spectroscopy ea NMR.
Fumana leseli mabapi le liphetoho tsa boemo ba limolek'hule ho HPMC nakong ea ho noa metsi.
5. Mehato ea liteko:
Tokiso ea Mohlala:
Netefatsa hore lisampole tsa HPMC li emela ts'ebeliso e reriloeng.
Laola lintlha tse kang boholo ba likaroloana le mongobo.
Teko ea boima ba 'mele:
Lekanya ka nepo sampole e lekantsoeng ea HPMC.
Kenya mohlala ka metsing ka nako e behiloeng.
Mohlala o ile oa omisoa 'me boima bo ile ba lekanngoa hape.
Lekanya ho bolokoa ha metsi.
Tekanyo ea index ea katoloso:
Lekanya molumo oa pele oa HPMC.
Kenya mohlala ka metsing 'me u lekanye molumo oa ho qetela.
Bala index ea katoloso.
Teko ea Centrifuge:
Kopanya HPMC le metsi 'me u lumelle ho leka-lekanya.
Centrifuge motsoako 'me u lekanye bophahamo ba metsi a bolokiloeng.
Lekanya ho bolokoa ha metsi.
Tlhahlobo ea NMR:
Ho lokisoa ha lisampole tsa HPMC-metsi bakeng sa tlhahlobo ea NMR.
Hlahloba liphetoho tsa liphetoho tsa lik'hemik'hale le matla a holimo.
Ho hokahanya lintlha tsa NMR le thepa ea ho boloka metsi.
6. Tlhahlobo ea lintlha le tlhaloso:
Hlalosa liphetho tse fumanoeng ka mokhoa o mong le o mong, ho ela hloko litlhoko tse khethehileng tsa kopo. Bapisa lintlha tse tsoang mekhoeng e fapaneng ho fumana kutloisiso e felletseng ea boitšoaro ba ho boloka metsi ba HPMC.
7. Liphephetso le maikutlo:
Buisanang ka mathata a ka bang teng mabapi le ho leka ho bolokoa ha metsi, joalo ka ho fapana ha lisampole tsa HPMC, maemo a tikoloho, le tlhokeho ea maemo.
8. Qetello:
Liphetho tsa mantlha li akaretsoa mme bohlokoa ba ho utloisisa thepa ea ho boloka metsi ea HPMC bakeng sa ts'ebeliso ea eona e atlehileng liindastering tse fapaneng e totobatsoa.
9. Litebello tsa kamoso:
Ho tšohloa tsoelo-pele e ka bang teng mekhoeng le mekhoeng ea tlhahlobo ho ntlafatsa kutloisiso ea rona ea thepa ea ho boloka metsi ea HPMC.
Nako ea poso: Dec-11-2023